日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Treatment with BKI-1748 after Toxoplasma gondii systemic dissemination in experimentally infected pregnant sheep improves fetal and lamb mortality and morbidity and prevents congenital infection.

在实验感染弓形虫的怀孕绵羊体内发生全身性播散后,用 BKI-1748 进行治疗可改善胎儿和羔羊的死亡率和发病率,并预防先天性感染

Sánchez-Sánchez Roberto, Huertas-López Ana, Largo-de la Torre Andrea, Ferre Ignacio, Dini Filippo Maria, Re Michela, Moreno-Gonzalo Javier, Choi Ryan, Hulverson Matthew A, Ojo Kayode K, Arnold Samuel L M, Hemphill Andrew, Van Voorhis Wesley C, Ortega-Mora Luis Miguel

Bumped Kinase Inhibitors Inhibit both Toxoplasma gondii MAPKL1 and CDPK1

激酶抑制剂可同时抑制弓形虫 MAPKL1 和 CDPK1。

Montgomery, Jemma A; Alday, P Holland; Choi, Ryan; Khim, Monique; Staker, Bart L; Hulverson, Matthew A; Ojo, Kayode K; Fan, Erkang; Van Voorhis, Wesley C; Doggett, J Stone

Versatile Imidazole Scaffold with Potent Activity against Multiple Apicomplexan Parasites.

多功能咪唑骨架,对多种顶复门寄生虫具有强效活性

Khim Monique, Montgomery Jemma, Laureano De Souza Mariana, Delvillar Melvin, Weible Lyssa J, Prabakaran Mayuri, Hulverson Matthew A, Eck Tyler, Bheemanabonia Rammohan Y, Alday P Holland, Rotella David P, Doggett J Stone, Staker Bart L, Ojo Kayode K, Bhanot Purnima

Anti-Cryptosporidium efficacy of BKI-1708, an inhibitor of Cryptosporidium calcium-dependent protein kinase 1

BKI-1708(一种隐孢子虫钙依赖性蛋白激酶1抑制剂)的抗隐孢子虫功效

Choi, Ryan; Hulverson, Matthew A; Schaefer, Deborah A; Betzer, Dana P; Riggs, Michael W; Huang, Wenlin; Sun, Vicky; Whitman, Grant R; McCloskey, Molly C; Marsh, Kennan; Buck, Wayne R; Wagner, David S; Yang, Junhai; Bowman, Andrew P; Ciurlionis, Rita; Ajiboye, Jubilee; Hemphill, Andrew; Sigalapalli, Dilep K; Arnold, Samuel L M; Barrett, Lynn K; Ojo, Kayode K; Fan, Erkang; Van Voorhis, Wesley C

Dose-dependent tissue tropism and efficacy of early BKI-1748 treatment in chronic Toxoplasma gondii infection in sheep

剂量依赖性组织趋向性和早期BKI-1748治疗对绵羊慢性弓形虫感染的疗效

Sánchez-Sánchez, Roberto; Calero-Bernal, Rafael; Velasco-Jiménez, Natalia; Gallego-Moreno, Irene; Pérez-Díaz, Carmen; Bustamante, Rocío; Choi, Ryan; Hulverson, Matthew A; Hemphill, Andrew; Van Voorhis, Wesley C; Ortega-Mora, Luis Miguel

Structure guided modification of 2-chloro-5-(ethyl-phenyl-sulfamoyl)-N-[2-(2-oxo-pyrrolidin-1-yl)-phenyl]-benzamide to afford selective inhibitors of Cryptosporidium parvum N-myristoyltransferase

以2-氯-5-(乙基苯基磺酰基)-N-[2-(2-氧代吡咯烷-1-基)苯基]-苯甲酰胺为模板,构建选择性小隐孢子虫N-肉豆蔻酰转移酶抑制剂

Sigalapalli, Dilep K; Groustra, Sophia; Fenwick, Michael K; Zigweid, Rachael; Hulverson, Matthew A; Owsley, Eric; Khim, Monique; Shibata, Sayaka; Van Voorhis, Wesley C; Staker, Bart L; Fan, Erkang

A Compound That Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer

一种抑制前列腺癌糖酵解的化合物可控制晚期前列腺癌的生长

Takuma Uo ,Kayode K Ojo ,Cynthia C T Sprenger ,Kathryn S Epilepsia ,B Gayani K Perera ,Mamatha Damodarasamy ,Shihua Sun ,Soojin Kim ,Hannah H Hogan ,Matthew A Hulverson ,Ryan Choi ,Grant R Whitman ,Lynn K Barrett ,Samantha A Michaels ,Linda H Xu ,Vicky L Sun ,Samuel L M Arnold ,Haley J Pang ,Matthew M Nguyen ,Anna-Lena B G Vigil ,Varun Kamat ,Lucas B Sullivan ,Ian R Sweet ,Ram Vidadala ,Dustin J Maly ,Wesley C Van Voorhis ,Stephen R Plymate

An Early Treatment With BKI-1748 Exhibits Full Protection Against Abortion and Congenital Infection in Sheep Experimentally Infected With Toxoplasma gondii

对实验感染弓形虫的绵羊进行早期BKI-1748治疗,可完全预防流产和先天性感染。

Sánchez-Sánchez, Roberto; Imhof, Dennis; Hecker, Yanina P; Ferre, Ignacio; Re, Michela; Moreno-Gonzalo, Javier; Blanco-Murcia, Javier; Mejías-López, Elena; Hulverson, Matthew A; Choi, Ryan; Arnold, Samuel L M; Ojo, Kayode K; Barrett, Lynn K; Hemphill, Andrew; Van Voorhis, Wesley C; Ortega-Mora, Luis Miguel

Efficacy of the bumped kinase inhibitor BKI-1708 against the cyst-forming apicomplexan parasites Toxoplasma gondii and Neospora caninum in vitro and in experimentally infected mice

体外和实验感染小鼠体内,凸起激酶抑制剂BKI-1708对形成包囊的顶复门寄生虫弓形虫和犬新孢子虫的疗效

de Sousa, Maria Cristina Ferreira; Imhof, Dennis; Hänggeli, Kai Pascal Alexander; Choi, Ryan; Hulverson, Matthew A; Arnold, Samuel L M; Van Voorhis, Wesley C; Fan, Erkang; Roberto, Sánchez-Sánchez; Ortega-Mora, Luis M; Hemphill, Andrew

Pyridopyrimidinones as a new chemotype of calcium dependent protein kinase 1 (CDPK1) inhibitors for Cryptosporidium

吡啶并嘧啶酮类化合物作为新型钙依赖性蛋白激酶1 (CDPK1) 抑制剂用于治疗隐孢子虫病

Waldron-Young, Elise; Wijitrmektong, Wissarut; Choi, Ryan; Whitman, Grant R; Hulverson, Matthew A; Charania, Raheela; Keelaghan, Aidan; Li, Li; Srinual, Songpol; Nikhar, Sameer; McNamara, Case W; Love, Melissa S; Huerta, Lauren; Bakowski, Malina A; Hu, Ming; Van Voorhis, Wesley C; Mead, Jan R; Cuny, Gregory D