日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Protocol for the generation and xenotransplantation of human induced pluripotent stem cell-derived neural progenitor cells into the mouse forebrain

将人诱导多能干细胞衍生的神经祖细胞生成并异种移植到小鼠前脑的方案

Julie J McInvale,Chloe E Ayers,Hemanta Sarmah,Kang Kim,Peter Reinhardt,Aayushi Mahajan,Nelson Humala,Barbara Corneo,Jared Sterneckert,Peter Canoll,Gunnar Hargus

IDH-mutant inhibitors enhance the sensitivity of IDH1-mutant gliomas to cysteine-methionine deprivation and ferroptosis.

IDH突变抑制剂可增强IDH1突变胶质瘤对半胱氨酸-蛋氨酸剥夺和铁死亡的敏感性。

Mela Angeliki, Brand Abby, Mahajan Aayushi, Dovas Athanassios, Humala Nelson, Kanangat Smriti, Kleinstein Allison C, Leskinen Sandra, Nguyen Trang Tt, Gao Qiuqiang, Upadhyayula Pavan S, Guo Jia, Gill Brian, Siegelin Markus D, Sims Peter A, Stockwell Brent R, Bruce Jeffrey N, Canoll Peter

Glioma-induced alterations in excitatory neurons are reversed by mTOR inhibition

胶质瘤引起的兴奋性神经元改变可通过抑制mTOR逆转。

Alexander R Goldberg ,Athanassios Dovas ,Daniela Torres ,Brianna Pereira ,Ashwin Viswanathan ,Sohani Das Sharma ,Angeliki Mela ,Edward M Merricks ,Cristina Megino-Luque ,Julie J McInvale ,Markel Olabarria ,Leila Abrishami Shokooh ,Hanzhi T Zhao ,Cady Chen ,Corina Kotidis ,Peter Calvaresi ,Matei A Banu ,Aida Razavilar ,Tejaswi D Sudhakar ,Ankita Saxena ,Cole Chokran ,Nelson Humala ,Aayushi Mahajan ,Weihao Xu ,Jordan B Metz ,Eric A Bushong ,Daniela Boassa ,Mark H Ellisman ,Elizabeth M C Hillman ,Gunnar Hargus ,Jose Javier Bravo-Cordero ,Guy M McKhann 2nd ,Brian J A Gill ,Steven S Rosenfeld ,Catherine A Schevon ,Jeffrey N Bruce ,Peter A Sims ,Darcy S Peterka ,Peter Canoll

A selective small-molecule agonist of G protein-gated inwardly-rectifying potassium channels reduces epileptiform activity in mouse models of tumor-associated and provoked seizures

选择性小分子G蛋白门控内向整流钾通道激动剂可降低肿瘤相关和诱发性癫痫小鼠模型中的癫痫样活动。

Rifkin, Robert A; Wu, Xiaoping; Pereira, Brianna; Gill, Brian Ja; Merricks, Edward M; Michalak, Andrew J; Goldberg, Alexander R; Humala, Nelson; Dovas, Athanassios; Rai, Ganesha; McKhann, Guy M; Slesinger, Paul A; Canoll, Peter; Schevon, Catherine

Immunoregulatory Imbalance in Preeclampsia: A Cross-Sectional Study of B7-H3 and Decidual NK Cell Interactions

先兆子痫免疫调节失衡:B7-H3和蜕膜NK细胞相互作用的横断面研究

Gumilar, Khanisyah Erza; Humala, Alexander Indra; Wardhana, Manggala Pasca; Ernawati, Ernawati; Sulistyono, Agus; Utomo, Budi; Ariani, Grace; Tan, Ming; Dachlan, Erry Gumilar; Dekker, Gus

Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons

骨桥蛋白驱动MAPT-N279K额颞叶痴呆患者神经元的神经炎症和细胞丢失

Osama Al-Dalahmah,Matti Lam,Julie J McInvale,Wenhui Qu,Trang Nguyen,Jeong-Yeon Mun,Sam Kwon,Nkechime Ifediora,Aayushi Mahajan,Nelson Humala,Tristan Winters,Ellen Angeles,Kelly A Jakubiak,Rebekka Kühn,Yoon A Kim,Maria Caterina De Rosa,Claudia A Doege,Fahad Paryani,Xena Flowers,Athanassios Dovas,Angeliki Mela,Hong Lu,Michael A DeTure,Jean Paul Vonsattel,Zbigniew K Wszolek,Dennis W Dickson,Tanja Kuhlmann,Holm Zaehres,Hans R Schöler,Andrew A Sproul,Markus D Siegelin,Philip L De Jager,James E Goldman,Vilas Menon,Peter Canoll,Gunnar Hargus

A cell state-specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma

胶质母细胞瘤中细胞状态特异性代谢易受 GPX4 依赖性铁死亡影响

Matei A Banu #, Athanassios Dovas #, Michael G Argenziano #, Wenting Zhao #, Colin P Sperring, Henar Cuervo Grajal, Zhouzerui Liu, Dominique Mo Higgins, Misha Amini, Brianna Pereira, Ling F Ye, Aayushi Mahajan, Nelson Humala, Julia L Furnari, Pavan S Upadhyayula, Fereshteh Zandkarimi, Trang Tt Nguye

Xenografted human iPSC-derived neurons with the familial Alzheimer's disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator

具有家族性阿尔茨海默病 APPV717I 突变的异种移植人类 iPSC 衍生神经元揭示了与突触功能相关的失调转录组特征,并暗示 LINGO2 是一种疾病信号介质

Wenhui Qu, Matti Lam, Julie J McInvale, Jason A Mares, Sam Kwon, Nelson Humala, Aayushi Mahajan, Trang Nguyen, Kelly A Jakubiak, Jeong-Yeon Mun, Thomas G Tedesco, Osama Al-Dalahmah, Syed A Hussaini, Andrew A Sproul, Markus D Siegelin, Philip L De Jager, Peter Canoll, Vilas Menon #, Gunnar Hargus #

OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma

OGDH 和 Bcl-xL 的缺失会导致胶质母细胞瘤的合成致死性

Trang Tt Nguyen ,Consuelo Torrini ,Enyuan Shang ,Chang Shu ,Jeong-Yeon Mun ,Qiuqiang Gao ,Nelson Humala ,Hasan O Akman ,Guoan Zhang ,Mike-Andrew Westhoff ,Georg Karpel-Massler ,Jeffrey N Bruce ,Peter Canoll ,Markus D Siegelin

EZH2 Inhibition Sensitizes IDH1R132H-Mutant Gliomas to Histone Deacetylase Inhibitor

EZH2抑制可使IDH1R132H突变型胶质瘤对组蛋白去乙酰化酶抑制剂敏感

Sprinzen, Lisa; Garcia, Franklin; Mela, Angeliki; Lei, Liang; Upadhyayula, Pavan; Mahajan, Aayushi; Humala, Nelson; Manier, Lisa; Caprioli, Richard; Quiñones-Hinojosa, Alfredo; Casaccia, Patrizia; Canoll, Peter