日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex

氧化型IL-33通过不依赖于ST2的RAGE/EGFR信号复合物驱动COPD上皮细胞的发病机制。

Strickson, Sam; Houslay, Kirsty F; Negri, Victor A; Ohne, Yoichiro; Ottosson, Tomas; Dodd, Roger B; Huntington, Catherine Chaillan; Baker, Tina; Li, Jingjing; Stephenson, Katherine E; O'Connor, Andy J; Sagawe, J Sophie; Killick, Helen; Moore, Tom; Rees, D Gareth; Koch, Sofia; Sanden, Caroline; Wang, Yixin; Gubbins, Elise; Ghaedi, Mahboobe; Kolbeck, Roland; Saumyaa, Saumyaa; Erjefält, Jonas S; Sims, Gary P; Humbles, Alison A; Scott, Ian C; Romero Ros, Xavier; Cohen, E Suzanne

Novel mechanisms of action contributing to benralizumab's potent anti-eosinophilic activity

促成贝那利珠单抗强效抗嗜酸性粒细胞活性的新型作用机制

Dagher, Rania; Kumar, Varsha; Copenhaver, Alan M; Gallagher, Sandra; Ghaedi, Mahboobe; Boyd, Jonathan; Newbold, Paul; Humbles, Alison A; Kolbeck, Roland

Eosinophils, basophils and type 2 immune microenvironments in COPD-affected lung tissue

慢性阻塞性肺病肺组织中的嗜酸性粒细胞、嗜碱性粒细胞和2型免疫微环境

Jogdand, Prajakta; Siddhuraj, Premkumar; Mori, Michiko; Sanden, Caroline; Jönsson, Jimmie; Walls, Andrew F; Kearley, Jennifer; Humbles, Alison A; Kolbeck, Roland; Bjermer, Leif; Newbold, Paul; Erjefält, Jonas S

IL-33-ST2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration

IL-33-ST2 轴调节髓系细胞分化和活化,从而实现有效的棒状细胞再生

Rania Dagher, Alan M Copenhaver, Valerie Besnard, Aaron Berlin, Fatima Hamidi, Marielle Maret, Jingya Wang, Xiaotao Qu, Yashaswi Shrestha, Jincheng Wu, Gregory Gautier, Rajiv Raja, Michel Aubier, Roland Kolbeck, Alison A Humbles #, Marina Pretolani #2

Microbial Regulation of Enteric Eosinophils and Its Impact on Tissue Remodeling and Th2 Immunity.

肠道嗜酸性粒细胞的微生物调节及其对组织重塑和 Th2 免疫的影响

Jiménez-Saiz Rodrigo, Anipindi Varun C, Galipeau Heather, Ellenbogen Yosef, Chaudhary Roopali, Koenig Joshua F, Gordon Melissa E, Walker Tina D, Mandur Talveer S, Abed Soumeya, Humbles Alison, Chu Derek K, Erjefält Jonas, Ask Kjetil, Verdú Elena F, Jordana Manel

Evaluation of 2-methoxy-4-nitroaniline (MNA) in hypersensitivity, 14-day subacute, reproductive, and genotoxicity studies

对 2-甲氧基-4-硝基苯胺 (MNA) 进行超敏反应、14 天亚急性毒性、生殖毒性和遗传毒性研究。

Frawley, Rachel P; Witt, Kristine L; Cunny, Helen; Germolec, Dori R; Jackson-Humbles, Daven; Malarkey, David; Shockley, Keith R; Stout, Matthew; Travlos, Greg; Buccellato, Matthew; Fallacara, Dawn; Harris, Shawn; Kissling, Grace E; Manheng, Wimolnut; Surh, Irene Inok; White, Kimber Jr; Auerbach, Scott S

IL-33 Mediates Lung Inflammation by the IL-6-Type Cytokine Oncostatin M

IL-33 通过 IL-6 型细胞因子抑癌素 M 介导肺部炎症

Fernando Botelho, Anisha Dubey, Ehab A Ayaub, Rex Park, Ashley Yip, Allison Humbles, Roland Kolbeck, Carl D Richards

Comparative toxicity and liver transcriptomics of legacy and emerging brominated flame retardants following 5-day exposure in the rat

大鼠暴露于传统和新兴溴化阻燃剂 5 天后的毒性和肝脏转录组学比较

Keith R Shockley, Michelle C Cora, David E Malarkey, Daven Jackson-Humbles, Molly Vallant, Brad J Collins, Esra Mutlu, Veronica G Robinson, Surayma Waidyanatha, Amy Zmarowski, Nicholas Machesky, Jamie Richey, Sam Harbo, Emily Cheng, Kristin Patton, Barney Sparrow, June K Dunnick

Transcriptomic data from the rat liver after five days of exposure to legacy or emerging brominated flame retardants

大鼠肝脏暴露于传统或新型溴化阻燃剂五天后的转录组数据

Shockley, Keith R; Cora, Michelle C; Malarkey, David E; Jackson-Humbles, Daven; Vallant, Molly; Collins, Brad J; Mutlu, Esra; Robinson, Veronica G; Waidyanatha, Surayma; Zmarowski, Amy; Machesky, Nicholas; Richey, Jamie; Harbo, Sam; Cheng, Emily; Patton, Kristin; Sparrow, Barney; Dunnick, June K

Isolation, Culture, and Induction of Plasticity in ILC2s

ILC2 的分离、培养和可塑性诱导

Jonathan Silver, Alison A Humbles, Yoichiro Ohne