日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR signalling complex

氧化型IL-33通过不依赖于ST2的RAGE/EGFR信号复合物驱动COPD上皮细胞的发病机制。

Strickson, Sam; Houslay, Kirsty F; Negri, Victor A; Ohne, Yoichiro; Ottosson, Tomas; Dodd, Roger B; Huntington, Catherine Chaillan; Baker, Tina; Li, Jingjing; Stephenson, Katherine E; O'Connor, Andy J; Sagawe, J Sophie; Killick, Helen; Moore, Tom; Rees, D Gareth; Koch, Sofia; Sanden, Caroline; Wang, Yixin; Gubbins, Elise; Ghaedi, Mahboobe; Kolbeck, Roland; Saumyaa, Saumyaa; Erjefält, Jonas S; Sims, Gary P; Humbles, Alison A; Scott, Ian C; Romero Ros, Xavier; Cohen, E Suzanne

Novel mechanisms of action contributing to benralizumab's potent anti-eosinophilic activity

促成贝那利珠单抗强效抗嗜酸性粒细胞活性的新型作用机制

Dagher, Rania; Kumar, Varsha; Copenhaver, Alan M; Gallagher, Sandra; Ghaedi, Mahboobe; Boyd, Jonathan; Newbold, Paul; Humbles, Alison A; Kolbeck, Roland

Eosinophils, basophils and type 2 immune microenvironments in COPD-affected lung tissue

慢性阻塞性肺病肺组织中的嗜酸性粒细胞、嗜碱性粒细胞和2型免疫微环境

Jogdand, Prajakta; Siddhuraj, Premkumar; Mori, Michiko; Sanden, Caroline; Jönsson, Jimmie; Walls, Andrew F; Kearley, Jennifer; Humbles, Alison A; Kolbeck, Roland; Bjermer, Leif; Newbold, Paul; Erjefält, Jonas S

Microbial Regulation of Enteric Eosinophils and Its Impact on Tissue Remodeling and Th2 Immunity.

肠道嗜酸性粒细胞的微生物调节及其对组织重塑和 Th2 免疫的影响

Jiménez-Saiz Rodrigo, Anipindi Varun C, Galipeau Heather, Ellenbogen Yosef, Chaudhary Roopali, Koenig Joshua F, Gordon Melissa E, Walker Tina D, Mandur Talveer S, Abed Soumeya, Humbles Alison, Chu Derek K, Erjefält Jonas, Ask Kjetil, Verdú Elena F, Jordana Manel

Distal respiratory tract viral infections in young children trigger a marked increase in alveolar mast cells

幼儿远端呼吸道病毒感染可引起肺泡肥大细胞显著增多。

Andersson, Cecilia K; Shikhagaie, Medya; Mori, Michiko; Al-Garawi, Amal; Reed, Jennifer L; Humbles, Alison A; Welliver, Robert; Mauad, Thais; Bjermer, Leif; Jordana, Manel; Erjefält, Jonas S

Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage

几丁质酶样蛋白通过IL-17介导的中性粒细胞增多症,在杀死线虫和损伤宿主之间取得平衡。

Sutherland, Tara E; Logan, Nicola; Rückerl, Dominik; Humbles, Alison A; Allan, Stuart M; Papayannopoulos, Venizelos; Stockinger, Brigitta; Maizels, Rick M; Allen, Judith E

Persistence of pulmonary tertiary lymphoid tissues and anti-nuclear antibodies following cessation of cigarette smoke exposure

停止吸烟后,肺部三级淋巴组织和抗核抗体仍然存在

Morissette, Mathieu C; Jobse, Brian N; Thayaparan, Danya; Nikota, Jake K; Shen, Pamela; Labiris, Nancy Renée; Kolbeck, Roland; Nair, Parameswaran; Humbles, Alison A; Stämpfli, Martin R

IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways.

IL-9 控制着肺部过敏原诱导的肥大细胞数量和气道的慢性重塑

Kearley Jennifer, Erjefalt Jonas S, Andersson Cecilia, Benjamin Ebony, Jones Carla P, Robichaud Annette, Pegorier Sophie, Brewah Yambasu, Burwell Timothy J, Bjermer Leif, Kiener Peter A, Kolbeck Roland, Lloyd Clare M, Coyle Anthony J, Humbles Alison A

Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation

在亚急性香烟烟雾暴露和过敏性气道炎症的小鼠模型中,乳腺退化蛋白39 (BRP-39) 的差异表达和功能

Nikota, Jake K; Botelho, Fernando M; Bauer, Carla Mt; Jordana, Manel; Coyle, Anthony J; Humbles, Alison A; Stampfli, Martin R

Lung chitinolytic activity and chitotriosidase are elevated in chronic obstructive pulmonary disease and contribute to lung inflammation.

慢性阻塞性肺病患者的肺几丁质分解活性和几丁质三糖酶水平升高,导致肺部炎症

Létuvé Séverine, Kozhich Alexander, Humbles Alison, Brewah Yambasu, Dombret Marie-Christine, Grandsaigne Martine, Adle Homa, Kolbeck Roland, Aubier Michel, Coyle Anthony J, Pretolani Marina