日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position

合成了与抗肿瘤药物替莫唑胺相关的咪唑并[5,1-d]-1,2,3,5-四嗪-8-甲酰胺类化合物，并在其3位引入了硅基、苄基和杂甲基，研究了这些化合物的生长抑制活性。

期刊:Medchemcomm
影响因子:
doi:10.1039/c7md00554g
Cousin, David; Hummersone, Marc G; Bradshaw, Tracey D; Zhang, Jihong; Moody, Christopher J; Foreiter, Magdalena B; Summers, Helen S; Lewis, William; Wheelhouse, Richard T; Stevens, Malcolm F G
肿瘤
肿瘤免疫
发表日期：2018
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Erratum: identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

勘误：鉴定出具有改进的毒理学特性和端粒靶向活性的新型RHPS4衍生物配体

期刊:Journal of Experimental & Clinical Cancer Research
影响因子:12.8
doi:10.1186/s13046-014-0101-x
Rizzo, Angela; Iachettini, Sara; Zizza, Pasquale; Cingolani, Chiara; Porru, Manuela; Artuso, Simona; Stevens, Malcolm; Hummersone, Marc; Biroccio, Annamaria; Salvati, Erica; Leonetti, Carlo
发表日期：2015
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Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

鉴定具有改进的毒理学特性和端粒靶向活性的新型RHPS4衍生物配体

期刊:Journal of Experimental & Clinical Cancer Research
影响因子:12.8
doi:10.1186/s13046-014-0081-x
Rizzo, Angela; Iachettini, Sara; Zizza, Pasquale; Cingolani, Chiara; Porru, Manuela; Artuso, Simona; Stevens, Malcolm; Hummersone, Marc; Biroccio, Annamaria; Salvati, Erica; Leonetti, Carlo
发表日期：2014
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On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts

基于五环吖啶盐的端粒解封G-四链体选择性配体的靶向和非靶向效应

期刊:Journal of Experimental & Clinical Cancer Research
影响因子:12.8
doi:10.1186/1756-9966-32-68
Iachettini, Sara; Stevens, Malcolm Fg; Frigerio, Mark; Hummersone, Marc G; Hutchinson, Ian; Garner, Thomas P; Searle, Mark S; Wilson, David W; Munde, Manoj; Nanjunda, Rupesh; D'Angelo, Carmen; Zizza, Pasquale; Rizzo, Angela; Cingolani, Chiara; De Cicco, Federica; Porru, Manuela; D'Incalci, Maurizio; Leonetti, Carlo; Biroccio, Annamaria; Salvati, Erica
发表日期：2013
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AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity

AZD8055 是一种强效、选择性、口服生物利用度高的 ATP 竞争性哺乳动物雷帕霉素激酶抑制剂，具有体外和体内抗肿瘤活性

期刊:Cancer Research
影响因子:12.5
doi:10.1158/0008-5472.CAN-09-1751
Christine M Chresta, Barry R Davies, Ian Hickson, Tom Harding, Sabina Cosulich, Susan E Critchlow, John P Vincent, Rebecca Ellston, Darren Jones, Patrizia Sini, Dominic James, Zoe Howard, Phillippa Dudley, Gareth Hughes, Lisa Smith, Sharon Maguire, Marc Hummersone, Karine Malagu, Keith Menear, Richa
肿瘤
发表日期：2010
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Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

改良型ATM激酶抑制剂KU-60019可增强胶质瘤细胞的放射敏感性，抑制胰岛素、AKT和ERK促生存信号通路，并抑制细胞迁移和侵袭。

期刊:Molecular Cancer Therapeutics
影响因子:5.5
doi:10.1158/1535-7163.MCT-09-0519
Golding, Sarah E; Rosenberg, Elizabeth; Valerie, Nicholas; Hussaini, Isa; Frigerio, Mark; Cockcroft, Xiaoling F; Chong, Wei Yee; Hummersone, Marc; Rigoreau, Laurent; Menear, Keith A; O'Connor, Mark J; Povirk, Lawrence F; van Meter, Timothy; Valerie, Kristoffer
细胞生物学
信号转导
MAPK/ERK
ATM
胶质瘤
AKT
免疫/内分泌
发表日期：2009
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