日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Transcription termination counteracts DNA damage after WEE1 inhibition.

转录终止可抵消 WEE1 抑制后的 DNA 损伤。

Landsverk Helga B, Sandquist Lise E, Bay Lilli T E, Hauge Sissel, van Bijsterveldt Linda, Lindbergsengen Lilian, Lund-Andersen Christin, Kanduri Chakravarthi, Lyng Heidi, Fjeldbo Christina S, Hompland Tord, Humphrey Timothy C, Syljuåsen Randi G

Homologous recombination suppresses transgenerational DNA end resection and chromosomal instability in fission yeast.

同源重组抑制裂殖酵母中的跨代DNA末端切除和染色体不稳定性

Pai Chen-Chun, Durley Samuel C, Cheng Wei-Chen, Chiang Nien-Yi, Peters Jennifer, Kasparek Torben, Blaikley Elizabeth, Wee Boon-Yu, Walker Carol, Kearsey Stephen E, Buffa Francesca, Murray Johanne M, Humphrey Timothy C

A role for SETD2 loss in tumorigenesis through DNA methylation dysregulation

SETD2缺失通过DNA甲基化失调在肿瘤发生中发挥作用

Javaid, Hira; Barberis, Alessandro; Chervova, Olga; Nassiri, Isar; Voloshin, Vitaly; Sato, Yusuke; Ogawa, Seishi; Fairfax, Benjamin; Buffa, Francesca; Humphrey, Timothy C

Using canavanine resistance to measure mutation rates in Schizosaccharomyces pombe.

利用卡那霉素抗性测定裂殖酵母的突变率

Pai Chen-Chun, Heitzer Ellen, Bertrand Sibyl, Toumazou Sophia, Humphrey Timothy C, Kearsey Stephen E

Inhibition of WEE1 Is Effective in TP53- and RAS-Mutant Metastatic Colorectal Cancer: A Randomized Trial (FOCUS4-C) Comparing Adavosertib (AZD1775) With Active Monitoring

抑制 WEE1 对 TP53 和 RAS 突变型转移性结直肠癌有效:一项比较 Adavosertib (AZD1775) 与主动监测的随机试验 (FOCUS4-C)

Seligmann, Jenny F; Fisher, David J; Brown, Louise C; Adams, Richard A; Graham, Janet; Quirke, Philip; Richman, Susan D; Butler, Rachel; Domingo, Enric; Blake, Andrew; Yates, Emma; Braun, Michael; Collinson, Fiona; Jones, Rob; Brown, Ewan; de Winton, Emma; Humphrey, Timothy C; Parmar, Mahesh; Kaplan, Richard; Wilson, Richard H; Seymour, Matthew; Maughan, Timothy S

Homologous recombination repair intermediates promote efficient de novo telomere addition at DNA double-strand breaks

同源重组修复中间体促进DNA双链断裂处高效的端粒从头添加。

Davé, Anoushka; Pai, Chen-Chun; Durley, Samuel C; Hulme, Lydia; Sarkar, Sovan; Wee, Boon-Yu; Prudden, John; Tinline-Purvis, Helen; Cullen, Jason K; Walker, Carol; Watson, Adam; Carr, Antony M; Murray, Johanne M; Humphrey, Timothy C

An essential role for dNTP homeostasis following CDK-induced replication stress.

CDK诱导的复制压力后,dNTP稳态发挥着至关重要的作用

Pai Chen-Chun, Hsu Kuo-Feng, Durley Samuel C, Keszthelyi Andrea, Kearsey Stephen E, Rallis Charalampos, Folkes Lisa K, Deegan Rachel, Wilkins Sarah E, Pfister Sophia X, De León Nagore, Schofield Christopher J, Bähler Jürg, Carr Antony M, Humphrey Timothy C

Use of the HPRT gene to study nuclease-induced DNA double-strand break repair

利用HPRT基因研究核酸酶诱导的DNA双链断裂修复

Gravells, Polly; Ahrabi, Sara; Vangala, Rajani K; Tomita, Kazunori; Brash, James T; Brustle, Lena A; Chung, Christopher; Hong, Julia M; Kaloudi, Aikaterini; Humphrey, Timothy C; Porter, Andrew C G

SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability.

SETD2 依赖的组蛋白 H3K36 三甲基化是同源重组修复和基因组稳定性所必需的

Pfister Sophia X, Ahrabi Sara, Zalmas Lykourgos-Panagiotis, Sarkar Sovan, Aymard François, Bachrati Csanád Z, Helleday Thomas, Legube Gaëlle, La Thangue Nicholas B, Porter Andrew C G, Humphrey Timothy C

Break-induced ATR and Ddb1-Cul4(Cdt)² ubiquitin ligase-dependent nucleotide synthesis promotes homologous recombination repair in fission yeast

断裂诱导的ATR和Ddb1-Cul4(Cdt)²泛素连接酶依赖的核苷酸合成促进裂殖酵母中的同源重组修复

Moss, Jennifer; Tinline-Purvis, Helen; Walker, Carol A; Folkes, Lisa K; Stratford, Michael R; Hayles, Jacqueline; Hoe, Kwang-Lae; Kim, Dong-Uk; Park, Han-Oh; Kearsey, Stephen E; Fleck, Oliver; Holmberg, Christian; Nielsen, Olaf; Humphrey, Timothy C