日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation.

扩大可成药锌指蛋白组,可以明确药物诱导降解的特性

Słabicki Mikołaj, Park Jiho, Nowak Radosław P, Roy Burman Shourya S, Pellman Jesse, Zou Charles, Razumkov Hlib, Carreiro Jeannie, Rastogi Simran, Goldstein Anna, Nagiec Marek M, Donovan Katherine A, Che Jianwei, Hunkeler Moritz, Geng Qixiang, Hsu Chi-Lin, Lakshminarayan Megha, Shu Chelsea, Zon Rebecca L, Kozicka Zuzanna, Park Paul M C, Tsai Jonathan M, Yoon Hojong, Jones Lyn H, Sperling Adam S, Gray Nathanael S, Fischer Eric S, Ebert Benjamin L

A degron-mimicking molecular glue drives CRBN homo-dimerization and degradation.

类似降解子的分子胶驱动 CRBN 同源二聚化和降解。

Langousis Gerasimos, Gainza Pablo, Hunkeler Moritz, Kapsitidou Despoina, Donckele Etienne J, Annunziato Stefano, Wiedmer Lars, Jones Katherine F M, DeMarco Bradley, Quan Chao, Bunker Richard D, Lumb Kevin J, Fasching Bernhard, Castle John C, Townson Sharon A, Bonenfant Débora

Structural basis of VCP-VCPIP1-p47 ternary complex in Golgi maintenance.

高尔基体维持中 VCP-VCPIP1-p47 三元复合物的结构基础

Shah Binita, Hunkeler Moritz, Bratt Ariana, Yue Hong, Jaen Maisonet Isabella, Fischer Eric S, Buhrlage Sara J

The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A.

KRAS剪接变体的差异相互作用组鉴定出BIRC6是KRAS4A的泛素连接酶

Kochen Rossi Juan, Nuevo-Tapioles Cristina, O'Keefe Rachel A, Hunkeler Moritz, Schmoker Anna M, Fissore-O'Leary Mercedes, Su Wenjuan, Ahearn Ian M, Branco Cristina, Cheong Hakyung, Esposito Dominic, Clotea Ioana, Ueberheide Beatrix, Fischer Eric S, Philips Mark R

Substrate adaptors are flexible tethering modules that enhance substrate methylation by the arginine methyltransferase PRMT5

底物适配器是灵活的连接模块,可增强精氨酸甲基转移酶PRMT5对底物的甲基化作用。

Jin, Cyrus Y; Hunkeler, Moritz; Mulvaney, Kathleen M; Sellers, William R; Fischer, Eric S

High-throughput diversification of protein-ligand surfaces to discover chemical inducers of proximity

利用高通量方法对蛋白质-配体表面进行多样化修饰,以发现邻近效应的化学诱导剂。

Shaum, James B; Muñoz I Ordoño, Miquel; Steen, Erica A; Wenge, Daniela V; Cheong, Hakyung; Hunkeler, Moritz; Bilotta, Eric M; Rutter, Zoe; Barta, Paige A; Thornhill, Abby M; Milosevich, Natalia; Hargis, Lauren M; Janowski, Jordan; Bishop, Timothy R; Carter, Trever R; da Camara, Bryce; Hinterndorfer, Matthias; Dada, Lucas; He, Wen-Ji; Offensperger, Fabian; Furihata, Hirotake; Schweber, Sydney R; Hatton, Charlie; Wen, Yanhe; Cravatt, Benjamin F; Engle, Keary M; Donovan, Katherine A; Melillo, Bruno; Kitamura, Seiya; Ciulli, Alessio; Armstrong, Scott A; Fischer, Eric S; Winter, Georg E; Erb, Michael A

The mycobacterial Mpa-proteasome unfolds and degrades pupylated substrates by engaging Pup's N-terminus

分枝杆菌Mpa蛋白酶体通过与Pup的N端结合,展开并降解pupylated底物。

Striebel, Frank; Hunkeler, Moritz; Summer, Heike; Weber-Ban, Eilika