日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Activation of L-histidine biosynthesis as a new antibiotic strategy against Mycobacterium tuberculosis

激活L-组氨酸生物合成作为对抗结核分枝杆菌的新型抗生素策略

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-026-70510-3
Hunt, Debbie M; Pisco, João Pedro; Rodgers, Angela; de Chiara, Cesira; Zaveri, Anisha; Pacholarz, Kamila L; Evangelopoulos, Dimitrios; Garza-Garcia, Acely; Ehrt, Sabine; Schnappinger, Dirk; Barran, Perdita E; Gutierrez, Maximiliano G; de Carvalho, Luiz Pedro S
发表日期：2026
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Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids

结核分枝杆菌通过大量重塑其脂质组，使其含有不含磷的脂质，从而克服磷酸盐缺乏。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-66437-w
Gray, Robert M; Hunt, Debbie M; Silva Dos Santos, Mariana; Liu, Jiuyu; Agapova, Aleksandra; Rodgers, Angela; Fearns, Antony; Canseco, Julio Ortiz; Garza-Garcia, Acely; MacRae, James I; Gutierrez, Maximiliano G; Lee, Richard E; de Carvalho, Luiz Pedro S
发表日期：2025
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Divergent downstream biosynthetic pathways are supported by <sc>L</sc>-cysteine synthases of Mycobacterium tuberculosis.

结核分枝杆菌的<sc>L</sc>-半胱氨酸合成酶支持不同的下游生物合成途径

期刊:Elife
影响因子:6.4
doi:10.7554/eLife.91970
Khan Mehak Zahoor, Hunt Debbie M, Singha Biplab, Kapoor Yogita, Singh Nitesh Kumar, Prasad D V Sai, Dharmarajan Sriram, Sowpati Divya Tej, de Carvalho Luiz Pedro S, Nandicoori Vinay Kumar
微生物学
发表日期：2024
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Cmr is a redox-responsive regulator of DosR that contributes to M. tuberculosis virulence.

Cmr 是 DosR 的氧化还原反应调节因子，有助于结核分枝杆菌的毒力

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkx406
Smith Laura J, Bochkareva Aleksandra, Rolfe Matthew D, Hunt Debbie M, Kahramanoglou Christina, Braun Yvonne, Rodgers Angela, Blockley Alix, Coade Stephen, Lougheed Kathryn E A, Hafneh Nor Azian, Glenn Sarah M, Crack Jason C, Le Brun Nick E, Saldanha José W, Makarov Vadim, Nobeli Irene, Arnvig Kristine, Mukamolova Galina V, Buxton Roger S, Green Jeffrey
微生物学
发表日期：2017
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Design, Synthesis, and Characterization of N-Oxide-Containing Heterocycles with in Vivo Sterilizing Antitubercular Activity

设计、合成和表征具有体内杀菌抗结核活性的含N-氧化物杂环化合物

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.7b01332
Dos Santos Fernandes, Guilherme Felipe; de Souza, Paula Carolina; Moreno-Viguri, Elsa; Santivañez-Veliz, Mery; Paucar, Rocio; Pérez-Silanes, Silvia; Chegaev, Konstantin; Guglielmo, Stefano; Lazzarato, Loretta; Fruttero, Roberta; Man Chin, Chung; da Silva, Patricia Bento; Chorilli, Marlus; Solcia, Mariana Cristina; Ribeiro, Camila Maríngolo; Silva, Caio Sander Paiva; Marino, Leonardo Biancolino; Bosquesi, Priscila Longhin; Hunt, Debbie M; de Carvalho, Luiz Pedro S; de Souza Costa, Carlos Alberto; Cho, Sang Hyun; Wang, Yuehong; Franzblau, Scott Gary; Pavan, Fernando Rogério; Dos Santos, Jean Leandro
发表日期：2017
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Cyclic-AMP and bacterial cyclic-AMP receptor proteins revisited: adaptation for different ecological niches

环磷酸腺苷和细菌环磷酸腺苷受体蛋白再探：对不同生态位的适应

期刊:Current Opinion in Microbiology
影响因子:7.5
doi:10.1016/j.mib.2014.01.003
Green, Jeffrey; Stapleton, Melanie R; Smith, Laura J; Artymiuk, Peter J; Kahramanoglou, Christina; Hunt, Debbie M; Buxton, Roger S
微生物学
信号转导
发表日期：2014
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Long range transcriptional control of virulence critical genes in Mycobacterium tuberculosis by nucleoid-associated proteins?

核样体相关蛋白对结核分枝杆菌毒力关键基因的长程转录调控？

期刊:Virulence
影响因子:5.4
doi:10.4161/viru.20918
Buxton, Roger S; Green, Jeffrey; Hunt, Debbie M; Kahramanoglou, Christina; Stapleton, Melanie R; Sweeney, Nathan P
信号转导
表观遗传
转录调控
发表日期：2012
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Mycobacterium tuberculosis WhiB1 is an essential DNA-binding protein with a nitric oxide-sensitive iron-sulfur cluster

结核分枝杆菌WhiB1是一种重要的DNA结合蛋白，具有对一氧化氮敏感的铁硫簇。

期刊:Biochemical Journal
影响因子:4.3
doi:10.1042/BJ20101440
Smith, Laura J; Stapleton, Melanie R; Fullstone, Gavin J M; Crack, Jason C; Thomson, Andrew J; Le Brun, Nick E; Hunt, Debbie M; Harvey, Evelyn; Adinolfi, Salvatore; Buxton, Roger S; Green, Jeffrey
发表日期：2010
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Single nucleotide polymorphisms that cause structural changes in the cyclic AMP receptor protein transcriptional regulator of the tuberculosis vaccine strain Mycobacterium bovis BCG alter global gene expression without attenuating growth

结核病疫苗株牛分枝杆菌卡介苗（Mycobacterium bovis BCG）环磷酸腺苷受体蛋白转录调节因子的单核苷酸多态性（SNP）会导致结构改变，从而改变整体基因表达，但不会减弱其生长。

期刊:Infection and Immunity
影响因子:2.8
doi:10.1128/IAI.01410-07
Hunt, Debbie M; Saldanha, José W; Brennan, John F; Benjamin, Pearline; Strom, Molly; Cole, Jeffrey A; Spreadbury, Claire L; Buxton, Roger S
信号转导
发表日期：2008
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An ABC transporter containing a forkhead-associated domain interacts with a serine-threonine protein kinase and is required for growth of Mycobacterium tuberculosis in mice

一种含有叉头相关结构域的ABC转运蛋白与丝氨酸/苏氨酸蛋白激酶相互作用，是结核分枝杆菌在小鼠体内生长所必需的。

期刊:Infection and Immunity
影响因子:2.8
doi:10.1128/IAI.73.8.4471-4477.2005
Curry, Juliet M; Whalan, Rachael; Hunt, Debbie M; Gohil, Kalpesh; Strom, Molly; Rickman, Lisa; Colston, M Joseph; Smerdon, Stephen J; Buxton, Roger S
信号转导
发表日期：2005
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