Monoclonal antibodies against GFRα3 are efficacious against evoked hyperalgesic and allodynic responses in mouse join pain models but, one of these, REGN5069, was not effective against pain in a randomized, placebo-controlled clinical trial in patients with osteoarthritis pain
针对 GFRα3 的单克隆抗体可有效对抗小鼠关节痛模型中诱发的痛觉过敏和异常性疼痛反应，但其中一种抗体 REGN5069 在一项针对骨关节炎疼痛患者的随机安慰剂对照临床试验中对疼痛无效
期刊:Neurobiology of Pain
影响因子:
doi:10.1016/j.ynpai.2023.100136
Selin Somersan-Karakaya, Kenneth C Turner, Luz Cortes-Burgos, Jutta Miller, Michael LaCroix-Fralish, Veronika Logovinsky, Yamini Patel, Richard Torres, Samit Ganguly, Aurora Breazna, Michelle DeVeaux, Rafia Bhore, Min Gao, Frank J Delfino, Ashique Rafique, Jeanette L Fairhurst, Charleen Hunt, Robert
