日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein.

通过靶向细胞表面 RNA 结合蛋白治疗急性髓系白血病模型。

George Benson M, Eleftheriou Maria, Yankova Eliza, Perr Jonathan, Chai Peiyuan, Nestola Gianluca, Almahayni Karim, Evans Siân, Damaskou Aristi, Hemberger Helena, Lebedenko Charlotta G, Rak Justyna, Yu Qi, Bapcum Ece, Russell James, Bagri Jaana, Volk Regan F, Spiekermann Malte, Stone Richard M, Giotopoulos George, Huntly Brian J P, Baxter Joanna, Camargo Fernando, Liu Jie, Zaro Balyn W, Vassiliou George S, Möckl Leonhard, de la Rosa Jorge, Flynn Ryan A, Tzelepis Konstantinos

Unravelling co-mutational patterns with prognostic implications in NPM1 mutated adult acute myeloid leukemia - a HARMONY study

揭示NPM1突变成人急性髓系白血病中具有预后意义的共突变模式——一项HARMONY研究

Hernández-Sánchez, Alberto; Villaverde Ramiro, Ángela; Sträng, Eric; Turki, Amin T; Abáigar, María; Versluis, Jurjen; Thomas, Ian; Sobas, Marta; Martínez Elicegui, Javier; Castellani, Gastone; Benner, Axel; Azibeiro, Raúl; Tettero, Jesse M; Mecklenbrauck, Rabea; Martínez-López, Joaquín; Pratcorona, Marta; Mills, Ken I; Sanz, Guillermo; Voso, Maria Teresa; Sören, Lehmann; Röllig, Christoph; Thiede, Christian; Metzeler, Klaus H; Döhner, Konstanze; Heuser, Michael; Haferlach, Torsten; Valk, Peter Jm; Russell, Nigel; Hernández-Rivas, Jesús María; Huntly, Brian; Ossenkoppele, Gert; Döhner, Hartmut; Bullinger, Lars

Prognostic impact of myelodysplasia-related gene mutations in FLT3-ITD-mutated acute myeloid leukemia

骨髓增生异常相关基因突变对FLT3-ITD突变型急性髓系白血病预后的影响

Mecklenbrauck, Rabea; Villaverde Ramiro, Angela; Sträng, Eric; Gabdoulline, Razif; Martinez Elicegui, Javier; Sobas, Marta; Pleyer, Lisa; Turki, Amin; Voso, Maria Teresa; Benner, Axel; Hernández-Sánchez, Alberto; Tettero, Jesse M; Tur Gimenez, Laura; Metzeler, Klaus H; Oñate, Guadalupe; Lehmann, Sören; Huntly, Brian Jp; Thomas, Ian; Thol, Felicitas R; Heidel, Florian H; Valk, Peter Jm; Döhner, Konstanze; Haferlach, Torsten; Mills, Kenneth I; Döhner, Hartmut; Castellani, Gastone; Ossenkoppele, Gert J; Hernández-Rivas, Jesus María; Bullinger, Lars; Heuser, Michael

Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia.

Polθ 活性调节 DNMT3A 缺陷型白血病对标准疗法的敏感性。

Le Bac Viet, Vekariya Umeshkumar, Toma Monika M, Nieborowska-Skorska Margaret, Caron Marie-Christine, Gozdecka Malgorzata, Haydar Zayd, Walsh Martin, Ghosh Jayashri, Vaughan-Williams Elaine, Podszywalow-Bartnicka Paulina, Kukuyan Anna-Mariya, Ziolkowska Sylwia, Atkins Jessica, Hadzijusufovic Emir, Chandramouly Gurushankar, Nejati Reza, Piwocka Katarzyna, Pomerantz Richard, Vassiliou George S, Huntly Brian J P, Valent Peter, Wasik Mariusz, Bellacosa Alfonso, Masson Jean-Yves, Gupta Gaorav P, Challen Grant A, Skorski Tomasz

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis

线粒体代谢维持DNMT3A-R882突变克隆性造血

Malgorzata Gozdecka,Monika Dudek #,Sean Wen #,Muxin Gu,Richard J Stopforth,Justyna Rak,Aristi Damaskou,Guinevere L Grice,Matthew A McLoughlin,Laura Bond,Rachael Wilson,George Giotopoulos,Vijaya Mahalingam Shanmugiah,Rula Bany Bakar,Eliza Yankova ,Jonathan L Cooper,Nisha Narayan,Sarah J Horton,Ryan Asby,Dean C Pask,Annalisa Mupo,Graham Duddy,Ludovica Marando,Theodoros Georgomanolis,Paul Carter,Amirtha Priya Ramesh,William G Dunn,Clea Barcena ,Paolo Gallipoli,Kosuke Yusa,Slavé Petrovski,Penny Wright,Pedro M Quiros ,Christian Frezza,James A Nathan,Arthur Kaser,Siddhartha Kar,Konstantinos Tzelepis ,Jonathan Mitchell,Margarete A Fabre ,Brian J P Huntly ,George S Vassiliou

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis

线粒体代谢维持DNMT3A-R882突变克隆性造血

Malgorzata Gozdecka ,Monika Dudek # ,Sean Wen # ,Muxin Gu ,Richard J Stopforth ,Justyna Rak ,Aristi Damaskou ,Guinevere L Grice ,Matthew A McLoughlin ,Laura Bond ,Rachael Wilson ,George Giotopoulos ,Vijaya Mahalingam Shanmugiah ,Rula Bany Bakar ,Eliza Yankova ,Jonathan L Cooper ,Nisha Narayan ,Sarah J Horton ,Ryan Asby ,Dean C Pask ,Annalisa Mupo ,Graham Duddy ,Ludovica Marando ,Theodoros Georgomanolis ,Paul Carter ,Amirtha Priya Ramesh ,William G Dunn ,Clea Barcena ,Paolo Gallipoli ,Kosuke Yusa ,Slavé Petrovski ,Penny Wright ,Pedro M Quiros ,Christian Frezza ,James A Nathan ,Arthur Kaser ,Siddhartha Kar ,Konstantinos Tzelepis ,Jonathan Mitchell ,Margarete A Fabre ,Brian J P Huntly ,George S Vassiliou

Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia

BCR::ABL1驱动的慢性粒细胞白血病的发生时间和轨迹

Kamizela, Aleksandra E; Leongamornlert, Daniel; Williams, Nicholas; Wang, Xin; Nyamondo, Kudzai; Dawson, Kevin; Spencer Chapman, Michael; Guo, Jing; Lee, Joe; Mane, Karim; Milne, Kate; Green, Anthony R; Chevassut, Timothy; Campbell, Peter J; Ellinor, Patrick T; Huntly, Brian J P; Baxter, E Joanna; Nangalia, Jyoti

Evidence of miR‐153‐3p association with Alzheimer's disease (AD) and the mechanism of miR‐153‐3p on critical proteins suggest a therapeutic and biomarker potential of miR‐153‐3p in AD and related dementias

miR-153-3p与阿尔茨海默病(AD)的关联证据以及miR-153-3p对关键蛋白的作用机制表明,miR-153-3p在AD及相关痴呆症中具有治疗和生物标志物方面的潜力。

Shah, Viral; Giotopoulos, George; Osaki, Hikari; Meyerhöfer, Markus; Meduri, Eshwar; Gallego-Crespo, Aaron; Behrendt, Malte A; Saura-Pañella, Maria; Tarkar, Aarti; Schubert, Benedict; Yun, Haiyang; Horton, Sarah J; Agrawal-Singh, Shuchi; Haehnel, Patricia S; Basheer, Faisal; Lugo, Dave; Eleftheriadou, Ioanna; Barbash, Olena; Dhar, Arindam; Kühn, Michael W M; Guezguez, Borhane; Theobald, Matthias; Kindler, Thomas; Gallipoli, Paolo; Yeh, Paul; Dawson, Mark A; Prinjha, Rab K; Huntly, Brian J P; Sasca, Daniel; Fish, Lauren A; Canchi, Saranya; Telpoukhovskaia, Maria; Luquez, Tain; Algoo, Jonathan; Hadad, Niran; Gurdon, Brianna; Dai, Miko; Ouellette, Andrew R; Neuner, Sarah M; Dunn, Amy R; Willcox, Jon A L; Wu, Yiyang; Dumitrescu, Logan; Bellur, Orhan; Zhang, Jigang; O'Connell, Kristen MS; Dammer, Eric B; Seyfried, Nicholas T; Muzumdar, Sukalp; Gillis, Jesse; Robson, Paul; Arnold, Matthias; Hohman, Timothy J; Philip, Vivek M; Menon, Vilas; Kaczorowski, Catherine C; Lahiri, Debomoy K; Wang, Ruizhi; Maloney, Bryan; Ghetti, Bernardino; Nho, Kwangsik; Farlow, Martin R; Saykin, Andrew J; White, Fletcher A; Sambamurti, Kumar; Counts, Scott E; Rosene, Matthew J; Lopez, Abraham; Ahmad, Adeeb; Romero, Skarleth Cardenas; Lai, Mei‐Yu; Benitez, Bruno A; Tish, Margaret M; Gao, Lauren; Ou, Zihui; Weinshenker, David; Birey, Fikri; Lahiri, Debomoy K; Wang, Ruizhi; Maloney, Bryan; Ghetti, Bernardino; Nho, Kwangsik; Farlow, Martin R; Saykin, Andrew J; White, Fletcher A; Sambamurti, Kumar; Counts, Scott E

Identification of epigenetic regulators of fibrotic transformation in cardiac fibroblasts through bulk and single-cell CRISPR screens.

通过批量和单细胞 CRISPR 筛选鉴定心脏成纤维细胞纤维化转化的表观遗传调控因子。

Aguado-Alvaro Laura Pilar, Garitano Nerea, Esser-Skala Wolfgang, Sayers Judy, Del Valle Cynthia, Alameda Daniel, Mendieta-Esteban Julen, Calleja-Cervantes Maria Erendira, Goñi-Salaverri Ainhoa, Zazpe Jon, de Vito Anna Rosaria, Marchese Francesco, Alignani Diego, Cudini Juliana, Gross Torsten, Rábago Gregorio, Narayan Nisha, Martinez Laura, Martinez Sonia, Huntly Brian, Riley Paul, Gonzalez Arantxa, Taylor-King Jake P, Fortelny Nikolaus, Pelacho Beatriz, Lara-Astiaso David

CREBBP inactivation sensitizes B cell acute lymphoblastic leukemia to ferroptotic cell death upon BCL2 inhibition

CREBBP失活使B细胞急性淋巴细胞白血病对BCL2抑制引起的铁死亡更加敏感

Alicia Garcia-Gimenez,Jonathan E Ditcham,Dhoyazan M A Azazi,George Giotopoulos,Ryan Asby,Eshwar Meduri,Jaana Bagri,Nathalie Sakakini,Cecile K Lopez,Nisha Narayan,Tumas Beinortas ,Shuchi Agrawal-Singh ,Kent Fung,David O'Connor,Marc R Mansour,Husam B R Alabed,Benjamin Jenkins,Albert Koulman,Michael P Murphy,Sarah J Horton,Brian J P Huntly ,Simon E Richardson