The protective up-regulation of metallothionein-2A in intervertebral disc degeneration inhibits nucleus pulposus cell ferroptosis through activation of the PI3K/AKT/mTOR pathway.
椎间盘退变中金属硫蛋白-2A的保护性上调通过激活PI3K/AKT/mTOR通路抑制髓核细胞铁死亡。
期刊:Cell Death Discovery
影响因子:7
doi:10.1038/s41420-026-02972-9
Cai Hao, Zheng Huo-Liang, Chen Qi-Zhu, Song Shao-Kuan, Yang Bing-Yi, Wang Yong, Deng Hui, Mardan Muradi, Lu Ze-Yu, Chen Peng-Bo, Xu Qing-Yin, Li Bo, Jiang Lei-Sheng, Zheng Xin-Feng, Jiang Sheng-Dan
细胞生物学
AKT
MTOR
PI3K/Akt
mTOR
铁死亡