日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Development of a high-throughput screening platform for C. difficile toxin synthesis inhibitors unveils meclizine as an antivirulence agent

利用高通量筛选平台筛选艰难梭菌毒素合成抑制剂,发现美克洛嗪是一种抗毒力药物。

Marreddy, Ravi K R; Nguyen, Nghi; Dureja, Chetna; McKelvey, Ann Marie; Powell, Reid; Olaitan, Abiola O; Stephan, Clifford; Hurdle, Julian G

Structural and Biochemical Characterization of Fusobacterium nucleatum Enoyl-ACP Reductase II (FabK) Reveals the Basis for Bacterial Species-Specific Inhibition

具核梭杆菌烯酰-ACP还原酶II (FabK) 的结构和生化表征揭示了细菌物种特异性抑制的基础

Avad, Kristiana; Alaidi, Osama; Okpomo, Destiny; Pavel, Fahad Bin Aziz; Doran, Darcy; Matheson, Madeline; Sun, Dianqing; Hurdle, Julian; Hevener, Kirk E

Systematic analysis of the type VII secretion system in Streptococcus gallolyticus subsp. gallolyticus reveals genomic diversity and functional associations

对溶血链球菌亚种VII型分泌系统的系统分析揭示了基因组多样性和功能关联

Calderon, Guadalupe; Tamang, Jyoti; Woodfin, Sarah; Prah, Isaac; Hurdle, Julian; Xu, Yi

Metabolic and Pharmacokinetic Profiling of a Ketone Ester by Background SGLT2 Inhibitor Therapy in HFrEF

在HFrEF患者中,SGLT2抑制剂背景治疗下酮酯的代谢和药代动力学特征分析

Selvaraj, Senthil; Kwee, Lydia Coulter; Thompson, Elizabeth J; He, Mengshu; Hornik, Christoph P; Devore, Adam D; Patel, Chetan B; Mentz, Robert J; Fudim, Marat; Taylor, Lacey; Milosovic, Stephanie; Hurdle, Melissa; Cade, William T; Ilkayeva, Olga; Muehlbauer, Michael J; Newgard, Christopher B; Kelly, Daniel P; Zamani, Payman; Margulies, Kenneth B; Shah, Svati H

The microbiome-restorative potential of ibezapolstat for the treatment of Clostridioides difficile infection is predicted through variant PolC-type DNA polymerase III in Lachnospiraceae and Oscillospiraceae

预测伊贝扎泊司他(ibezapolstat)可通过毛螺菌科(Lachnospiraceae)和奥斯氏螺菌科(Oscillospiraceae)中的变异型PolC型DNA聚合酶III,发挥其修复微生物群、治疗艰难梭菌感染的潜力。

McPherson, Jacob K; Hurdle, Julian G; Baker, Matthew L; Hussain, Tahir; Kumar, Ashok; Garey, Kevin W

GLP-1 agonists: a game changer in pain treatment and addiction

GLP-1受体激动剂:疼痛治疗和成瘾治疗领域的变革者

Bade, Sahil; Hurdle, Mark Friedrich B; Bade, Sohail; Encalada, Sebastian; Kanahan-Osman, Sharima; Gupta, Sahil

Optimizing patient understanding of spine MRI reports using AI: A prospective single center study

利用人工智能优化患者对脊柱MRI报告的理解:一项前瞻性单中心研究

Encalada, Sebastian; Gupta, Sahil; Hunt, Christine; Eldrige, Jason; Evans, John 2nd; Mosquera-Moscoso, Johanna; Pessoa de Mendonca, Laura Furtado; Kanahan-Osman, Sharima; Bade, Sohail; Bade, Sahil; Ivicic, Lisbet; Foskey, Stephanie; Lyles, Jason; Suarez, Juan; Fisher, Aaron; Khan, Hamaad; Stone, Jeffrey A; Hurdle, Mark

Letter to the Editor regarding "Lumbar facet joint denervation targeting the medial branch in the sub-mammillary fossa: An anatomical optimization study"

致编辑的信,主题为“针对乳头下窝内侧支的腰椎小关节去神经支配术:一项解剖优化研究”

Caroço, Tomás; Kubrova, Eva; Gupta, Sahil; Hurdle, Mark Friedrich B

Reduced Vancomycin Susceptibility in Clostridioides difficile Is Associated With Lower Rates of Initial Cure and Sustained Clinical Response

艰难梭菌对万古霉素敏感性降低与初始治愈率和持续临床反应率较低相关。

Eubank, Taryn A; Dureja, Chetna; Garey, Kevin W; Hurdle, Julian G; Gonzales-Luna, Anne J

In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy

苯基咪唑对艰难梭菌烯酰-ACP还原酶II (FabK) 抑制作用的体内评价揭示了一种有前景的窄谱抗菌策略

Dureja, Chetna; Rutherford, Jacob T; Pavel, Fahad B A; Norseeda, Krissada; Prah, Isaac; Sun, Dianqing; Hevener, Kirk E; Hurdle, Julian G