日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Non-Nucleoside Lycorine-Based Analogs as Potential DENV/ZIKV NS5 Dual Inhibitors: Structure-Based Virtual Screening and Chemoinformatic Analysis

非核苷类石蒜碱类似物作为潜在的登革病毒/寨卡病毒NS5双重抑制剂:基于结构的虚拟筛选和化学信息学分析

Rodríguez-Ararat, Adrián Camilo; Hayek-Orduz, Yasser; Vásquez, Andrés-Felipe; Sierra-Hurtado, Felipe; Villegas-Torres, María-Francisca; Caicedo-Burbano, Paola A; Achenie, Luke E K; Barrios, Andrés Fernando González

Phase I Study of Taminadenant (PBF509/NIR178), an Adenosine 2A Receptor Antagonist, with or without Spartalizumab (PDR001), in Patients with Advanced Non-Small Cell Lung Cancer

一项针对晚期非小细胞肺癌患者的I期研究,评估腺苷2A受体拮抗剂Taminadenant(PBF509/NIR178)联合或不联合Spartalizumab(PDR001)的疗效。

Chiappori, Alberto A; Creelan, Ben; Tanvetyanon, Tawee; Gray, Jhanelle E; Haura, Eric B; Thapa, Ram; Barlow, Margaret L; Chen, Zhihua; Chen, Dung Tsa; Beg, Amer A; Boyle, Theresa A; Castro, Julio; Morgan, Liza; Morris, Erick; Aregay, Mehreteab; Hurtado, Felipe K; Manenti, Luigi; Antonia, Scott

Effect of ceritinib on the pharmacokinetics of coadministered CYP3A and 2C9 substrates: a phase I, multicenter, drug-drug interaction study in patients with ALK + advanced tumors

色瑞替尼对同时给药的 CYP3A 和 2C9 底物药代动力学的影响:一项针对 ALK 阳性晚期肿瘤患者的 I 期多中心药物相互作用研究

Hurtado, Felipe K; de Braud, Filippo; De Castro Carpeño, Javier; de Miguel Luken, Maria Jose; Wang, Ding; Scott, Jeffrey; Lau, Yvonne Y; McCulloch, Tracey; Mau-Sorensen, Morten

The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins.

原核病毒包膜蛋白的结构拓展了膜融合蛋白的研究领域

El Omari Kamel, Li Sai, Kotecha Abhay, Walter Thomas S, Bignon Eduardo A, Harlos Karl, Somerharju Pentti, De Haas Felix, Clare Daniel K, Molin Mika, Hurtado Felipe, Li Mengqiu, Grimes Jonathan M, Bamford Dennis H, Tischler Nicole D, Huiskonen Juha T, Stuart David I, Roine Elina

The Ferric uptake regulator (Fur) and iron availability control the production and maturation of the antibacterial peptide microcin E492

铁摄取调节因子(Fur)和铁的可用性控制着抗菌肽微生素E492的产生和成熟。

Marcoleta, Andrés E; Gutiérrez-Cortez, Sergio; Hurtado, Felipe; Argandoña, Yerko; Corsini, Gino; Monasterio, Octavio; Lagos, Rosalba

Bacterial Tubulins A and B Exhibit Polarized Growth, Mixed-Polarity Bundling, and Destabilization by GTP Hydrolysis

细菌微管蛋白A和B表现出极性生长、混合极性束状结构以及GTP水解导致的稳定性降低

Díaz-Celis, César; Risca, Viviana I; Hurtado, Felipe; Polka, Jessica K; Hansen, Scott D; Maturana, Daniel; Lagos, Rosalba; Mullins, R Dyche; Monasterio, Octavio

Population pharmacokinetic modeling of the unbound levofloxacin concentrations in rat plasma and prostate tissue measured by microdialysis

采用微透析法测定大鼠血浆和前列腺组织中游离左氧氟沙星浓度,并建立群体药代动力学模型

Hurtado, Felipe K; Weber, Benjamin; Derendorf, Hartmut; Hochhaus, Guenther; Dalla Costa, Teresa