日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Discovery of an Orally Efficacious Pyrazolo[3,4-d]pyrimidine Benzoxaborole as a Potent Inhibitor of Cryptosporidium

发现一种口服有效的吡唑并[3,4-d]嘧啶苯并硼氧杂环化合物是隐孢子虫的强效抑制剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.4c02805
Gasonoo, Makafui; Guin, Soumitra; Teixeira, José E; Oboh, Edmund; Gokanapalle, Anusha; Miller, Peter; Oliva, Jonathan; Sverdrup, Francis M; Huston, Christopher D; Meyers, Marvin J
发表日期：2025
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A propidium iodide-based in vitro screen of the "Bug Box" against Babesia duncani reveals potent inhibitors.

利用碘化丙啶对“Bug Box”进行体外筛选，以对抗邓氏巴贝虫，结果发现了强效抑制剂

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/aac.00035-25
Dews Emmett A, Teixeira José E, Huston Christopher D, Meyers Marvin J, Hyson Peter R
信号转导
发表日期：2025
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Organoid-based in vitro system and reporter for the study of Cryptosporidium parvum sexual reproduction

基于类器官的体外系统和报告系统用于研究小隐孢子虫的有性生殖

期刊:Microbiology Spectrum
影响因子:3.8
doi:10.1128/spectrum.00502-25
Korwin-Mihavics, Bethany R; Dews, Emmett A; Miller, Peter; Cameron, Alexandra; Martorelli di Genova, Bruno; Huston, Christopher D
3D/类器官
发表日期：2025
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Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy

隐孢子虫赖氨酰tRNA合成酶抑制剂阐明了溶解度和渗透性之间的相互作用，而这种相互作用是实现疗效所必需的。

期刊:Science Translational Medicine
影响因子:14.6
doi:10.1126/scitranslmed.adm8631
Caldwell, Nicola; Peet, Caroline; Miller, Peter; Colon, Beatrice L; Taylor, Malcolm G; Cocco, Mattia; Dawson, Alice; Lukac, Iva; Teixeira, Jose E; Robinson, Lee; Frame, Laura; Seizova, Simona; Damerow, Sebastian; Tamaki, Fabio; Post, John; Riley, Jennifer; Mutter, Nicole; Hanna, Jack C; Ferguson, Liam; Hu, Xiao; Tinti, Michele; Forte, Barbara; Norcross, Neil R; Campbell, Peter S; Svensen, Nina; Caldwell, Flora C; Jansen, Chimed; Postis, Vincent; Read, Kevin D; Huston, Christopher D; Gilbert, Ian H; Baragaña, Beatriz; Pawlowic, Mattie C
发表日期：2024
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Structure-Activity Relationship Studies of the Aryl Acetamide Triazolopyridazines against Cryptosporidium Reveals Remarkable Role of Fluorine

芳基乙酰胺三唑并哒嗪类化合物抗隐孢子虫的构效关系研究揭示了氟的显著作用

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.3c00110
Schubert, Tanner J; Oboh, Edmund; Peek, Hannah; Philo, Emily; Teixeira, José E; Stebbins, Erin E; Miller, Peter; Oliva, Jonathan; Sverdrup, Francis M; Griggs, David W; Huston, Christopher D; Meyers, Marvin J
发表日期：2023
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Structure-Activity relationships of replacements for the triazolopyridazine of Anti-Cryptosporidium lead SLU-2633

抗隐孢子虫先导化合物 SLU-2633 三唑并哒嗪取代物的构效关系

期刊:Bioorganic & Medicinal Chemistry
影响因子:3
doi:10.1016/j.bmc.2023.117295
Oboh, Edmund; Teixeira, José E; Schubert, Tanner J; Maribona, Adriana S; Denman, Brylon N; Patel, Radhika; Huston, Christopher D; Meyers, Marvin J
发表日期：2023
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The Clofazimine for Treatment of Cryptosporidiosis in HIV-Infected Adults (CRYPTOFAZ) and Lessons Learned for Anticryptosporidial Drug Development

用于治疗 HIV 感染成人隐孢子虫病的氯法齐明 (CRYPTOFAZ) 及其在抗隐孢子虫药物研发中的经验教训

期刊:Clinical Infectious Diseases
影响因子:7.3
doi:10.1093/cid/ciaa425
Huston, Christopher D
HIV
炎症/感染
微生物学
发表日期：2021
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Impact and costs of a hepatitis C virus screening programme for adults hospitalised at an academic medical centre

学术医疗中心住院成人丙型肝炎病毒筛查项目的影响和成本

期刊:BMJ Open Quality
影响因子:1.6
doi:10.1136/bmjoq-2020-001248
Whitman, Timothy J; Noyes, Cindy D; Hale, Andrew J; Singh, Devika; DeVoe, Stephen G; Repp, Allen B; Pierce, Kristen K; Polish, Louis B; Kirkpatrick, Beth D; Dejace, Jean; Smith, Lindsay M; Lahey, Tim; Huston, Christopher D; Catoe, Laura J; Ghatage, Prateek; Bullis, Sean; Alston, W Kemper
微生物学
肝炎
发表日期：2021
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Bicyclic azetidines kill the diarrheal pathogen Cryptosporidium in mice by inhibiting parasite phenylalanyl-tRNA synthetase

双环氮杂环丁烷类化合物通过抑制寄生虫苯丙氨酰-tRNA合成酶，杀死小鼠体内引起腹泻的病原体隐孢子虫。

期刊:Science Translational Medicine
影响因子:14.6
doi:10.1126/scitranslmed.aba8412
Vinayak, Sumiti; Jumani, Rajiv S; Miller, Peter; Hasan, Muhammad M; McLeod, Briana I; Tandel, Jayesh; Stebbins, Erin E; Teixeira, Jose E; Borrel, Julien; Gonse, Arthur; Zhang, Mingliang; Yu, Xianshui; Wernimont, Amy; Walpole, Chris; Eckley, Sean; Love, Melissa S; McNamara, Case W; Sharma, Manmohan; Sharma, Amit; Scherer, Christina A; Kato, Nobutaka; Schreiber, Stuart L; Melillo, Bruno; Striepen, Boris; Huston, Christopher D; Comer, Eamon
微生物学
发表日期：2020
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Cryptosporidiosis should be designated as a tropical disease by the US Food and Drug Administration

美国食品药品监督管理局应将隐孢子虫病指定为热带病。

期刊:PLoS Neglected Tropical Diseases
影响因子:3.4
doi:10.1371/journal.pntd.0008252
Choy, Robert K M; Huston, Christopher D
发表日期：2020
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