日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and clinical translation of ceperognastat, an O-GlcNAcase (OGA) inhibitor, for the treatment of Alzheimer's disease

发现并临床转化了 O-GlcNAcase (OGA) 抑制剂 ceperognastat 用于治疗阿尔茨海默病

Kielbasa, William; Goldsmith, Paul; Donnelly, Kevin B; Nuthall, Hugh N; Shcherbinin, Sergey; Fleisher, Adam S; Hendle, Jörg; DuBois, Susan L; Lowe, Stephen L; Zhang, Feiyu Fred; Woerly, Eric M; Dreyfus, Nicolas J-F; Evans, David; Gilmore, Jeremy; Mancini, Michele; Constantinescu, Cristian C; Gunn, Roger N; Russell, David S; Collins, Emily C; Brys, Miroslaw; Hutton, Michael L; Mergott, Dustin J

Identification of Intervention Opportunities through Assessment of the Appropriateness of Antibiotic Prescribing in Surgical Patients in a UK Hospital Using a National Audit Tool: A Single Centre Retrospective Audit

利用国家审计工具评估英国某医院外科患者抗生素处方合理性,从而识别干预机会:一项单中心回顾性审计

Hearsey, Daniel John; Bamford, Kathleen B; Hutton, Michael; Wade, Liam; Coates, Henry; Ramsay, Elizabeth; Alberts, Barbara; Powell, Neil

Dynamic Radiographs in Assessing Stability of Cervical Spine Fractures: A Multicentre Study

动态X线片在评估颈椎骨折稳定性中的应用:一项多中心研究

Thumbadoo, Ruben Patrick; Herzog, Jan; Bhamber, Niv; Lupu, Cristina; Kwan, Kenny; Clarke, Andrew; Hutton, Michael; Bernard, Jason; Bishop, Timothy; Lui, Darren F

Clostridioides difficile infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease

艰难梭菌感染通过 TcdB 损害结肠干细胞,损害上皮修复和疾病恢复

Steven J Mileto, Thierry Jardé, Kevin O Childress, Jaime L Jensen, Ashleigh P Rogers, Genevieve Kerr, Melanie L Hutton, Michael J Sheedlo, Sarah C Bloch, John A Shupe, Katja Horvay, Tracey Flores, Rebekah Engel, Simon Wilkins, Paul J McMurrick, D Borden Lacy, Helen E Abud, Dena Lyras

Imbalance in the response of pre- and post-synaptic components to amyloidopathy

突触前和突触后成分对淀粉样变性的反应失衡

Stephen, Terri-Leigh; Tamagnini, Francesco; Piegsa, Judith; Sung, Katherine; Harvey, Joshua; Oliver-Evans, Alice; Murray, Tracey K; Ahmed, Zeshan; Hutton, Michael L; Randall, Andrew; O'Neill, Michael J; Jackson, Johanna S

Development and validation of two clinical prediction models to inform clinical decision-making for lumbar spinal fusion surgery for degenerative disorders and rehabilitation following surgery: protocol for a prospective observational study

开发和验证两种临床预测模型,以指导腰椎融合术治疗退行性疾病的临床决策和术后康复:一项前瞻性观察研究方案

Rushton, Alison B; Verra, Martin L; Emms, Andrew; Heneghan, Nicola R; Falla, Deborah; Reddington, Michael; Cole, Ashley A; Willems, Paul; Benneker, Lorin; Selvey, David; Hutton, Michael; Heymans, Martijn W; Staal, J Bart

Alzheimer's Disease-Related Dementias Summit 2016: National research priorities

2016年阿尔茨海默病相关痴呆症峰会:国家研究重点

Corriveau, Roderick A; Koroshetz, Walter J; Gladman, Jordan T; Jeon, Sophia; Babcock, Debra; Bennett, David A; Carmichael, S Thomas; Dickinson, Susan L-J; Dickson, Dennis W; Emr, Marian; Fillit, Howard; Greenberg, Steven M; Hutton, Michael L; Knopman, David S; Manly, Jennifer J; Marder, Karen S; Moy, Claudia S; Phelps, Creighton H; Scott, Paul A; Seeley, William W; Sieber, Beth-Anne; Silverberg, Nina B; Sutherland, Margaret L; Taylor, Angela; Torborg, Christine L; Waddy, Salina P; Gubitz, Amelie K; Holtzman, David M

Altered Synapse Stability in the Early Stages of Tauopathy

tau蛋白病早期阶段突触稳定性改变

Jackson, Johanna S; Witton, Jonathan; Johnson, James D; Ahmed, Zeshan; Ward, Mark; Randall, Andrew D; Hutton, Michael L; Isaac, John T; O'Neill, Michael J; Ashby, Michael C

Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau

短纤维构成了人类 P301S Tau 转基因小鼠脑中种子活性 Tau 的主要种类

Samuel J Jackson, Caroline Kerridge, Jane Cooper, Annalisa Cavallini, Benjamin Falcon, Claire V Cella, Alessia Landi, Philip G Szekeres, Tracey K Murray, Zeshan Ahmed, Michel Goedert, Michael Hutton, Michael J O'Neill, Suchira Bose

Halting of Caspase Activity Protects Tau from MC1-Conformational Change and Aggregation

抑制半胱天冬酶活性可保护Tau蛋白免受MC1构象变化和聚集的影响

Mead, Emma; Kestoras, Dimitra; Gibson, Yolanda; Hamilton, Lucy; Goodson, Ross; Jones, Sophie; Eversden, Sarah; Davies, Peter; O'Neill, Michael; Hutton, Michael; Szekeres, Philip; Wolak, Joanna