日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and clinical translation of ceperognastat, an O-GlcNAcase (OGA) inhibitor, for the treatment of Alzheimer's disease

发现并临床转化了 O-GlcNAcase (OGA) 抑制剂 ceperognastat 用于治疗阿尔茨海默病

Kielbasa, William; Goldsmith, Paul; Donnelly, Kevin B; Nuthall, Hugh N; Shcherbinin, Sergey; Fleisher, Adam S; Hendle, Jörg; DuBois, Susan L; Lowe, Stephen L; Zhang, Feiyu Fred; Woerly, Eric M; Dreyfus, Nicolas J-F; Evans, David; Gilmore, Jeremy; Mancini, Michele; Constantinescu, Cristian C; Gunn, Roger N; Russell, David S; Collins, Emily C; Brys, Miroslaw; Hutton, Michael L; Mergott, Dustin J

Imbalance in the response of pre- and post-synaptic components to amyloidopathy

突触前和突触后成分对淀粉样变性的反应失衡

Stephen, Terri-Leigh; Tamagnini, Francesco; Piegsa, Judith; Sung, Katherine; Harvey, Joshua; Oliver-Evans, Alice; Murray, Tracey K; Ahmed, Zeshan; Hutton, Michael L; Randall, Andrew; O'Neill, Michael J; Jackson, Johanna S

Alzheimer's Disease-Related Dementias Summit 2016: National research priorities

2016年阿尔茨海默病相关痴呆症峰会:国家研究重点

Corriveau, Roderick A; Koroshetz, Walter J; Gladman, Jordan T; Jeon, Sophia; Babcock, Debra; Bennett, David A; Carmichael, S Thomas; Dickinson, Susan L-J; Dickson, Dennis W; Emr, Marian; Fillit, Howard; Greenberg, Steven M; Hutton, Michael L; Knopman, David S; Manly, Jennifer J; Marder, Karen S; Moy, Claudia S; Phelps, Creighton H; Scott, Paul A; Seeley, William W; Sieber, Beth-Anne; Silverberg, Nina B; Sutherland, Margaret L; Taylor, Angela; Torborg, Christine L; Waddy, Salina P; Gubitz, Amelie K; Holtzman, David M

Altered Synapse Stability in the Early Stages of Tauopathy

tau蛋白病早期阶段突触稳定性改变

Jackson, Johanna S; Witton, Jonathan; Johnson, James D; Ahmed, Zeshan; Ward, Mark; Randall, Andrew D; Hutton, Michael L; Isaac, John T; O'Neill, Michael J; Ashby, Michael C

Conformation determines the seeding potencies of native and recombinant Tau aggregates

构象决定了天然和重组Tau蛋白聚集体的成核能力。

Falcon, Benjamin; Cavallini, Annalisa; Angers, Rachel; Glover, Sarah; Murray, Tracey K; Barnham, Luanda; Jackson, Samuel; O'Neill, Michael J; Isaacs, Adrian M; Hutton, Michael L; Szekeres, Philip G; Goedert, Michel; Bose, Suchira

Recommendations of the Alzheimer's disease-related dementias conference

阿尔茨海默病相关痴呆症会议的建议

Montine, Thomas J; Koroshetz, Walter J; Babcock, Debra; Dickson, Dennis W; Galpern, Wendy R; Glymour, M Maria; Greenberg, Steven M; Hutton, Michael L; Knopman, David S; Kuzmichev, Andrey N; Manly, Jennifer J; Marder, Karen S; Miller, Bruce L; Phelps, Creighton H; Seeley, William W; Sieber, Beth-Anne; Silverberg, Nina B; Sutherland, Margaret; Torborg, Christine L; Waddy, Salina P; Zlokovic, Berislav V; Corriveau, Roderick A

SLC20A2 and THAP1 deletion in familial basal ganglia calcification with dystonia

SLC20A2 和 THAP1 缺失与家族性基底神经节钙化伴肌张力障碍有关

Baker, Matt; Strongosky, Audrey J; Sanchez-Contreras, Monica Y; Yang, Shan; Ferguson, Will; Calne, Donald B; Calne, Susan; Stoessl, A Jon; Allanson, Judith E; Broderick, Daniel F; Hutton, Michael L; Dickson, Dennis W; Ross, Owen A; Wszolek, Zbigniew K; Rademakers, Rosa

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

一种新型体内tau蛋白传播模型,可观察到快速进展的神经原纤维缠结病理:传播模式由连接性决定,而非邻近性。

Ahmed, Zeshan; Cooper, Jane; Murray, Tracey K; Garn, Katya; McNaughton, Emily; Clarke, Hannah; Parhizkar, Samira; Ward, Mark A; Cavallini, Annalisa; Jackson, Samuel; Bose, Suchira; Clavaguera, Florence; Tolnay, Markus; Lavenir, Isabelle; Goedert, Michel; Hutton, Michael L; O'Neill, Michael J

Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression

在两种转基因模型中,使用抗Tau抗体进行被动免疫可减少Tau病理并延缓疾病进展。

Chai, Xiyun; Wu, Su; Murray, Tracey K; Kinley, Robert; Cella, Claire V; Sims, Helen; Buckner, Nicola; Hanmer, Jenna; Davies, Peter; O'Neill, Michael J; Hutton, Michael L; Citron, Martin

Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging.

颗粒蛋白敲除小鼠中加速的脂褐素沉积和泛素化表明前颗粒蛋白在成功衰老中发挥作用

Ahmed Zeshan, Sheng Hong, Xu Ya-Fei, Lin Wen-Lang, Innes Amy E, Gass Jennifer, Yu Xin, Wuertzer Charles A, Hou Harold, Chiba Shuichi, Yamanouchi Keitaro, Leissring Malcolm, Petrucelli Leonard, Nishihara Masugi, Hutton Michael L, McGowan Eileen, Dickson Dennis W, Lewis Jada