日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
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2025
2026
影响因子:
–

Organoids as a personalized medicine tool for ultra-rare mutations in cystic fibrosis: The case of S955P and 1717-2A>G.

类器官作为囊性纤维化中超罕见突变的个性化医疗工具：S955P 和 1717-2A>G 的案例

期刊:Biochimica et Biophysica Acta-Molecular Basis of Disease
影响因子:4.2
doi:10.1016/j.bbadis.2020.165905
Silva Iris A L, Doušová Tereza, Ramalho Sofia, Centeio Raquel, Clarke Luka A, Railean Violeta, Botelho Hugo M, Holubová Andrea, Valášková Iveta, Yeh Jiunn-Tyng, Hwang Tzyh-Chang, Farinha Carlos M, Kunzelmann Karl, Amaral Margarida D
3D/类器官
发表日期：2020
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Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222

CFTR 校正剂 ABBV-2222/GLPG2222 对 F508delCFTR 蛋白加工的生物学特性

期刊:Journal of Pharmacology and Experimental Therapeutics
影响因子:3.8
doi:10.1124/jpet.119.261800
Singh, Ashvani K; Fan, Yihong; Balut, Corina; Alani, Sara; Manelli, Arlene M; Swensen, Andrew M; Jia, Ying; Neelands, Torben R; Vortherms, Timothy A; Liu, Bo; Searle, Xenia B; Wang, Xueqing; Gao, Wenqing; Hwang, Tzyh-Chang; Ren, Hong Y; Cyr, Douglas; Kym, Philip R; Conrath, Katja; Tse, Chris
CFTR
发表日期：2020
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Structural mechanisms for defective CFTR gating caused by the Q1412X mutation, a severe Class VI pathogenic mutation in cystic fibrosis.

由 Q1412X 突变引起的 CFTR 门控缺陷的结构机制，这是囊性纤维化中严重的 VI 类致病突变

期刊:Journal of Physiology-London
影响因子:4.4
doi:10.1113/JP277042
Yeh Jiunn-Tyng, Yu Ying-Chun, Hwang Tzyh-Chang
其它
发表日期：2019
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Identification and Characterization of Novel CFTR Potentiators

新型CFTR增强剂的鉴定和表征

期刊:Frontiers in Pharmacology
影响因子:4.8
doi:10.3389/fphar.2018.01221
Gees, Maarten; Musch, Sara; Van der Plas, Steven; Wesse, Anne-Sophie; Vandevelde, Ann; Verdonck, Katleen; Mammoliti, Oscar; Hwang, Tzyh-Chang; Sonck, Kathleen; Stouten, Pieter; Swensen, Andrew M; Jans, Mia; Van der Schueren, Jan; Nelles, Luc; Andrews, Martin; Conrath, Katja
CFTR
发表日期：2018
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Structural mechanisms of CFTR function and dysfunction

CFTR功能和功能障碍的结构机制

期刊:Journal of General Physiology
影响因子:2.9
doi:10.1085/jgp.201711946
Hwang, Tzyh-Chang; Yeh, Jiunn-Tyng; Zhang, Jingyao; Yu, Ying-Chun; Yeh, Han-I; Destefano, Samantha
CFTR
发表日期：2018
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CFTR potentiators: from bench to bedside

CFTR 增强剂：从实验室到临床

期刊:Current Opinion in Pharmacology
影响因子:4.2
doi:10.1016/j.coph.2017.09.015
Jih, Kang-Yang; Lin, Wen-Ying; Sohma, Yoshiro; Hwang, Tzyh-Chang
CFTR
发表日期：2017
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On the mechanism of gating defects caused by the R117H mutation in cystic fibrosis transmembrane conductance regulator

囊性纤维化跨膜传导调节因子R117H突变导致门控缺陷的机制

期刊:Journal of Physiology-London
影响因子:4.4
doi:10.1113/JP271723
Yu, Ying-Chun; Sohma, Yoshiro; Hwang, Tzyh-Chang
发表日期：2016
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Synergistic Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Gating by Two Chemically Distinct Potentiators, Ivacaftor (VX-770) and 5-Nitro-2-(3-Phenylpropylamino) Benzoate

两种化学性质不同的增强剂伊伐卡托 (VX-770) 和 5-硝基-2-(3-苯基丙基氨基)苯甲酸酯对囊性纤维化跨膜电导调节器门控的协同增强作用

期刊:Molecular Pharmacology
影响因子:3
doi:10.1124/mol.116.104570
Lin, Wen-Ying; Sohma, Yoshiro; Hwang, Tzyh-Chang
发表日期：2016
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Localizing a gate in CFTR

定位CFTR中的门控区域

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1420676112
Gao, Xiaolong; Hwang, Tzyh-Chang
CFTR
发表日期：2015
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Modulation of CFTR gating by permeant ions

渗透离子对CFTR门控的调节

期刊:Journal of General Physiology
影响因子:2.9
doi:10.1085/jgp.201411272
Yeh, Han-I; Yeh, Jiunn-Tyng; Hwang, Tzyh-Chang
CFTR
发表日期：2015
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