日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A small molecule chaperone rescues keratin-8 mediated trafficking of misfolded podocin to correct genetic Nephrotic Syndrome

小分子伴侣挽救角蛋白 8 介导的错误折叠足蛋白运输,以纠正遗传性肾病综合征

Valeryia Kuzmuk, Iwona Pranke, Ruth Rollason, Matthew Butler, Wen Y Ding, Matthew Beesley, Aoife M Waters, Richard J Coward, Richard Sessions, Jack Tuffin, Rebecca R Foster, Géraldine Mollet, Corinne Antignac, Aleksander Edelman, Gavin I Welsh, Moin A Saleem

Correction: Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes

更正:肝素酶抑制剂作为一种系统性方法,可保护内皮糖萼并预防糖尿病微血管并发症。

Gamez, Monica; E Elhegni, Hesham; Fawaz, Sarah; Ho Ho, Kwan; W Campbell, Neill; A Copland, David; L Onions, Karen; J Butler, Matthew; J Wasson, Elizabeth; Crompton, Michael; D Ramnath, Raina; Qiu, Yan; Yamaguchi, Yu; P Arkill, Kenton; O Bates, David; E Turnbull, Jeremy; V Zubkova, Olga; I Welsh, Gavin; Atan, Denize; C Satchell, Simon; R Foster, Rebecca

Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes

肝素酶抑制作为保护内皮糖萼和预防糖尿病微血管并发症的系统方法

Monica Gamez, Hesham E Elhegni, Sarah Fawaz, Kwan Ho Ho, Neill W Campbell, David A Copland, Karen L Onions, Matthew J Butler, Elizabeth J Wasson, Michael Crompton, Raina D Ramnath, Yan Qiu, Yu Yamaguchi, Kenton P Arkill, David O Bates, Jeremy E Turnbull, Olga V Zubkova, Gavin I Welsh, Denize Atan, S

Contrasting consequences of podocyte insulin-like growth factor 1 receptor inhibition

足细胞胰岛素样生长因子1受体抑制的相反后果

Jennifer A Hurcombe ,Fern Barrington ,Micol Marchetti ,Virginie M S Betin ,Emily E Bowen ,Abigail C Lay ,Lan Ni ,Lusyan Dayalan ,Robert J P Pope ,Paul T Brinkkoetter ,Martin Holzenberger ,Gavin I Welsh ,Richard J M Coward

Proteomic profiling of kidney biopsies in nephrotic syndrome

肾病综合征肾活检的蛋白质组学分析

Emily Williams #, Maryline Fresquet #, Anna S Li #, Craig Lawless, David Knight, Elizabeth Colby, Judy Watson, Gavin I Welsh, Moin A Saleem, Rachel Lennon

Podocyte protease activated receptor 1 stimulation in mice produces focal segmental glomerulosclerosis mirroring human disease signaling events

足细胞蛋白酶激活受体 1 刺激小鼠产生局灶节段性肾小球硬化,类似人类疾病信号事件

Carl J May, Musleeha Chesor, Sarah E Hunter, Bryony Hayes, Rachel Barr, Tim Roberts, Fern A Barrington, Louise Farmer, Lan Ni, Maisie Jackson, Heidi Snethen, Nadia Tavakolidakhrabadi, Max Goldstone, Rodney Gilbert, Matt Beesley, Rachel Lennon, Rebecca Foster, Richard Coward, Gavin I Welsh, Moin A Sa

Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx

糖尿病中盐皮质激素受体拮抗剂可通过保护肾小球内皮糖萼来减少蛋白尿。

Michael Crompton,Joanne K Ferguson,Raina D Ramnath,Karen L Onions,Anna S Ogier,Monica Gamez,Colin J Down,Laura Skinner,Kitty H Wong,Lauren K Dixon,Judit Sutak,Steven J Harper,Paola Pontrelli,Loreto Gesualdo,Hiddo L Heerspink,Robert D Toto,Gavin I Welsh,Rebecca R Foster,Simon C Satchell,Matthew J Butler

Highly efficient CRISPR-mediated large DNA docking and multiplexed prime editing using a single baculovirus

利用单个杆状病毒实现高效的 CRISPR 介导的大片段 DNA 对接和多重启动编辑

Francesco Aulicino ,Martin Pelosse ,Christine Toelzer ,Julien Capin ,Erwin Ilegems ,Parisa Meysami ,Ruth Rollarson ,Per-Olof Berggren ,Mark Simon Dillingham ,Christiane Schaffitzel ,Moin A Saleem ,Gavin I Welsh ,Imre Berger

Reduced Glomerular Filtration in Diabetes Is Attributable to Loss of Density and Increased Resistance of Glomerular Endothelial Cell Fenestrations

糖尿病患者肾小球滤过率降低是由于肾小球内皮细胞孔密度降低和阻力增加所致

Natalie C Finch, Sarah S Fawaz, Chris R Neal, Matthew J Butler, Vivian K Lee, Andrew J Salmon, Abigail C Lay, Megan Stevens, Lusyan Dayalan, Hamid Band, Harry H Mellor, Steven J Harper, David T Shima, Gavin I Welsh, Rebecca R Foster, Simon C Satchell

Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice

糖尿病性心肌病中内皮糖萼受损:血管生成素 1 可修复小鼠糖萼并改善舒张功能

Yan Qiu, Stanley Buffonge, Raina Ramnath, Sophie Jenner, Sarah Fawaz, Kenton P Arkill, Chris Neal, Paul Verkade, Stephen J White, Melanie Hezzell, Andrew H J Salmon, M-Saadeh Suleiman, Gavin I Welsh, Rebecca R Foster, Paolo Madeddu, Simon C Satchell