I-Shing相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Human teratozoospermia-related AGTPBP1 R791H mutation is associated with sperm head and tail defects in a CRISPR-engineered murine model

人类畸形精子症相关的AGTPBP1 R791H突变与CRISPR基因编辑小鼠模型中的精子头部和尾部缺陷有关。

期刊:Journal of Assisted Reproduction and Genetics

影响因子:2.7

doi:10.1007/s10815-025-03732-x

Wang, Ya-Yun; Lin, Yu-Hua; Ke, Chih-Chun; Lai, Tsung-Hsuan; Yu, I-Shing; Au, Chin-Fong; Singh, Rajender; Lin, Ying-Hung

发表日期：2026

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Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity

阿司匹林通过限制血小板TXA2对T细胞免疫的抑制作用来预防转移。

影响因子:50.5

doi:10.1038/s41586-025-08626-7

Jie Yang ，Yumi Yamashita-Kanemaru ，Benjamin I Morris ，Annalisa Contursi ，Daniel Trajkovski ，Jingru Xu ，Ilinca Patrascan ，Jayme Benson ，Alexander C Evans ，Alberto G Conti ，Aws Al-Deka ，Layla Dahmani ，Adnan Avdic-Belltheus ，Baojie Zhang ，Hanneke Okkenhaug ，Sarah K Whiteside ，Charlotte J Imianowski ，Alexander J Wesolowski ，Louise V Webb ，Simone Puccio ，Stefania Tacconelli ，Annalisa Bruno ，Sara Di Berardino ，Alessandra De Michele ，Heidi C E Welch ，I-Shing Yu ，Shu-Wha Lin ，Suman Mitra ，Enrico Lugli ，Louise van der Weyden ，Klaus Okkenhaug ，Kourosh Saeb-Parsy ，Paola Patrignani ，David J Adams ，Rahul Roychoudhuri

细胞生物学

免疫/内分泌

发表日期：2025

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Latent-TGF-β has a domain swapped architecture

潜伏型TGF-β具有结构域交换结构

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-65465-w

Jin, Mingliang; Seed, Robert I; Shing, Tiffany; Wang, Li; Li, Junrui; Cheng, Yifan; Nishimura, Stephen L

发表日期：2025

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Mir221- and Mir222-enriched adsc-exosomes mitigate PM exposure-exacerbated cardiac ischemia-reperfusion injury through the modulation of the BNIP3-MAP1LC3B-BBC3/PUMA pathway

富含 Mir221 和 Mir222 的 adsc 外泌体通过调节 BNIP3-MAP1LC3B-BBC3/PUMA 通路减轻 PM 暴露加剧的心脏缺血再灌注损伤

期刊:Autophagy

影响因子:14.6

doi:10.1080/15548627.2024.2395799

Tzu-Lin Lee, Wen-Chi Shen, Ya-Chun Chen, Tsai-Chun Lai, Shu-Rung Lin, Shu-Wha Lin, I-Shing Yu, Yen-Hsiu Yeh, Tsai-Kun Li, I-Ta Lee, Chiang-Wen Lee, Yuh-Lien Chen

发表日期：2025

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PTPN22-CD45 dual phosphatase retrograde feedback enhances TCR signaling and autoimmunity.

PTPN22-CD45 双磷酸酶逆向反馈增强 TCR 信号传导和自身免疫

期刊:Science Advances

影响因子:12.5

doi:10.1126/sciadv.adw2568

Yang Shen, Santelli Eugenio, Gonzalez Carlos G, Johnson Wade T, Choi Irene V, Zhuang Chuling, Ro Myungja, Rossitto Leigh-Ana M, Yu I-Shing, Lin Shu-Wha, Zhan Yuan, Chen Qinwei, Yoshihara Jonathan D, Wallace Daniel J, Jefferies Caroline A, Yamashita Michifumi, Gonzalez David J, Ainsworth Richard I, Shah Nisarg J, Stanford Stephanie M, Bottini Nunzio

免疫/内分泌

发表日期：2025

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MiR221/222 in the conditioned medium of adipose-derived stem cells attenuates particulate matter and high-fat diet-induced cardiac apoptosis

脂肪来源干细胞条件培养基中的miR221/222可减轻颗粒物和高脂饮食诱导的心肌细胞凋亡

期刊:Stem Cell Research & Therapy

影响因子:7.1

doi:10.1186/s13287-025-04381-8

Ya-Chun Chen ，Chi-Ming Pu ，Shu-Rung Lin ，Shu-Wha Lin ，I-Shing Yu ，Ho-Jun Shih ，Chiang-Wen Lee ，Ming-Hsueh Lee ，Yen-Ting Kuo ，Yuh-Lien Chen

细胞生物学

发育与干细胞

发表日期：2025

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Spint1 disruption in mouse pancreas leads to glucose intolerance and impaired insulin production involving HEPSIN/MAFA

小鼠胰腺中的 Spint1 破坏导致葡萄糖不耐受和涉及 HEPSIN/MAFA 的胰岛素产生受损

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-024-54927-2

Hsin-Hsien Lin, I-Shing Yu, Ming-Shan Cheng, Tien-Jyun Chang, Hsin-Ying Lin, Yi-Cheng Chang, Chun-Jung Ko, Ping-Hung Chen, Shu-Wha Lin, Tai-Chung Huang, Shin-Yi Huang, Tzu-Yu Chen, Kai-Wen Kan, Hsiang-Po Huang, Ming-Shyue Lee0

发表日期：2024

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Hepsin as a potential therapeutic target for alleviating acetaminophen-induced hepatotoxicity via gap-junction regulation and oxidative stress modulation.

Hepsin 可通过调节间隙连接和氧化应激来缓解对乙酰氨基酚引起的肝毒性，成为潜在的治疗靶点

期刊:Cell Biology and Toxicology

影响因子:5.9

doi:10.1007/s10565-024-09915-z

Tsai Yu-Fei, Chen Chien-Hung, Wu Yao-Ming, Hung Chia-Lu, Fang Mo-Chu, Yu I-Shing, Sheu Jin-Chuan, Hsu Yu-Chen, Lin Shu-Wha

发表日期：2024

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Enhancement of adult liver regeneration in mice through the hepsin-mediated epidermal growth factor receptor signaling pathway

通过肝蛋白酶介导的表皮生长因子受体信号通路增强小鼠成年肝脏再生

期刊:Communications Biology

影响因子:5.2

doi:10.1038/s42003-024-07357-1

Yu-Fei Tsai, Mo-Chu Fang, Chien-Hung Chen, I-Shing Yu, Chia-Tung Shun, Mi-Hua Tao, Cheng-Pu Sun, Jean Lu, Jin-Chuan Sheu, Yu-Chen Hsu #, Shu-Wha Lin #5

发表日期：2024

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Deleterious genetic changes in AGTPBP1 result in teratozoospermia with sperm head and flagella defects

AGTPBP1 的有害基因变化导致精子头部和鞭毛缺陷的畸形精子症

期刊:Journal of Cellular and Molecular Medicine

影响因子:4.3

doi:10.1111/jcmm.18031

Yu-Hua Lin, Ya-Yun Wang, Tsung-Hsuan Lai, Jih-Lung Teng, Chi-Wei Lin, Chih-Chun Ke, I-Shing Yu, Hui-Ling Lee, Chying-Chyuan Chan, Chi-Hua Tung, Donald F Conrad, Moira K O'Bryan, Ying-Hung Lin

发表日期：2024

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