日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Antibody-oligonucleotide conjugate achieves CNS delivery in animal models for spinal muscular atrophy

抗体-寡核苷酸偶联物在脊髓性肌萎缩动物模型中实现了中枢神经系统递送

Suzan M Hammond, Frank Abendroth, Larissa Goli, Jessica Stoodley, Matthew Burrell, George Thom, Ian Gurrell, Nina Ahlskog, Michael J Gait, Matthew Ja Wood, Carl I Webster

A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model

一种源自黑素转铁蛋白的肽可跨 BBB 递送基于蛋白质的白细胞介素 1 受体拮抗剂,并在临床前模型中缓解神经性疼痛

George Thom, Mei-Mei Tian, Jon P Hatcher, Natalia Rodrigo, Matthew Burrell, Ian Gurrell, Timothy Z Vitalis, Thomas Abraham, Wilfred A Jefferies, Carl I Webster, Reinhard Gabathuler

Enhanced delivery of IL-1 receptor antagonist to the central nervous system as a novel anti-transferrin receptor-IL-1RA fusion reverses neuropathic mechanical hypersensitivity

作为新型抗转铁蛋白受体-IL-1RA 融合物,增强 IL-1 受体拮抗剂向中枢神经系统的输送,可逆转神经性机械超敏反应

Carl I Webster, Jon Hatcher, Matthew Burrell, George Thom, Peter Thornton, Ian Gurrell, Iain Chessell