日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multiomics Profiling of T-cell Leukemia and Lymphoma Enables Targeted Therapeutic Discovery.

T细胞白血病和淋巴瘤的多组学分析可实现靶向治疗的发现。

Ianevski Aleksandr, Nader Kristen, Nguyen Julia, Sorger Helena, Timonen Sanna, Julia Edith, Pölöske Daniel, Spirk Katrin, Wagner Christina, Jungherz Dennis, Nakano Minoru, Kadambat Nair Sisira, Ianevski Philipp, Kankainen Matti, Dias Diogo, Cichońska Anna, Pemovska Tea, Pirker Christine, Berger Walter, Braun Till, Moriggl Richard, Bachy Emmanuel, Mustjoki Satu, Herling Marco, Neubauer Heidi A, Haibe-Kains Benjamin, Aittokallio Tero

Combination of vemurafenib, pleconaril, and AG7404 attenuates enterovirus replication in vitro and in vivo

维莫非尼、普利可那利和AG7404联合用药可在体外和体内减弱肠道病毒的复制。

Ravlo, Erlend; Ianevski, Aleksandr; Wolska, Waleria; Schjølberg, Jørn-Ove; Cámara-Quílez, María; Nordli, Ine Emilie Olsen; Sæther, Ingrid Bjørnes; Lysvand, Hilde; Oksenych, Valentyn; Vähä-Koskela, Markus; Vainionpää, Sanna; Seppänen, Hanna; Smura, Teemu; Vauhkonen, Hanna; Odai, Roni; Stoyanova, Adelina; Galabov, Simeon A; Galabov, Angel S; Plevka, Pavel; Nekoua, Magloire Pandoua; Hober, Didier; Bjørås, Magnar; Kainov, Denis E

High-throughput drug screening identifies SMAC mimetics as enhancers of NK-cell cytotoxicity in chronic myeloid leukemia

高通量药物筛选发现SMAC模拟物可增强慢性粒细胞白血病中NK细胞的细胞毒性。

Nygrén, Petra; Bouhlal, Jonas; Jokinen, Emmi; Forstén, Sofia; Laajala, Essi; Dias, Diogo; Adnan-Awad, Shady; Ianevski, Aleksandr; Klievink, Jay; Lähteenmäki, Hanna; Kuusanmäki, Heikki; Myllymäki, Mikko; Kasanen, Tiina; Saeed, Khalid; Lee, Dean A; Hjorth-Hansen, Henrik; Aittokallio, Tero; Dufva, Olli; Mustjoki, Satu

A Machine Learning-Based Strategy Predicts Selective and Synergistic Drug Combinations for Relapsed Acute Myeloid Leukemia

基于机器学习的策略预测复发性急性髓系白血病的选择性和协同药物组合

Chen, Yingjia; He, Liye; Ianevski, Aleksandr; Nader, Kristen; Ruokoranta, Tanja; Linnavirta, Nora; Miettinen, Juho J; Vähä-Koskela, Markus; Vänttinen, Ida; Kuusanmäki, Heikki; Kontro, Mika; Porkka, Kimmo; Wennerberg, Krister; Heckman, Caroline A; Giri, Anil K; Aittokallio, Tero

Dual STAT3/STAT5 inhibition as a novel treatment strategy in T-prolymphocytic leukemia

双重 STAT3/STAT5 抑制作为 T 前淋巴细胞白血病的一种新型治疗策略

Annika Dechow ,Sanna Timonen ,Aleksandr Ianevski ,Qu Jiang ,Linus Wahnschaffe ,Yayi Peng ,Dennis Jungherz ,Kerstin Becker ,Heidi A Neubauer ,Susann Schönefeldt ,Elvin de Araujo ,Patrick Gunning ,Roman Fleck ,Alexandra Schrader ,Michael Hallek ,Natali Pflug ,Richard Moriggl ,Tero Aittokallio ,Satu Mustjoki ,Till Braun # ,Marco Herling #

Discovery of molecularly-informed therapeutic strategies for mature T-cell leukemias and lymphomas

发现针对成熟T细胞白血病和淋巴瘤的分子指导治疗策略

Schmidt, Nicole; Kornrumpf, Kevin; Ries, Lena; Markus, Katharina; Ksionsko, Nora Anna Maria; Mazzeo, Paolo; Lohrberg, Melanie; Sitte, Maren; Salinas, Gabriela; Braun, Till; Dechow, Annika; Herling, Marco; Ianevski, Aleksandr; Aittokallio, Tero; Chapuy, Björn; Bastians, Holger; Wulf, Gerald; Beißbarth, Tim; Dönitz, Jürgen; Koch, Raphael

Synergistic combination of orally available safe-in-man pleconaril, AG7404, and mindeudesivir inhibits enterovirus infections in human cell and organoid cultures

口服安全药物普利可那利、AG7404 和明德西韦的协同作用可抑制人类细胞和类器官培养物中的肠道病毒感染

Erlend Ravlo #, Aleksandr Ianevski #, Jørn-Ove Schjølberg, Vanessa Solvang, Rabina Dumaru, Hilde Lysvand, Jacqueline Hankinson, Markus Vähä-Koskela, Sanna Vainionpää, Anni Varhe, Hanna Seppänen, Teemu Smura, Xin Wang, Yining Wang, Pengfei Li, Qiuwei Pan, Knut Dahl-Jorgensen, Lars Krogvold, Oleksandr

Spatial artifact detection improves the reproducibility of drug screening experiments

空间伪影检测可提高药物筛选实验的可重复性

Ianevski, Aleksandr; Nader, Kristen; Potdar, Swapnil; Gorbonos, Alexandra; Ianevski, Filipp; Tanoli, Ziaurrehman; Saarela, Jani; Aittokallio, Tero

Single-cell transcriptomes identify patient-tailored therapies for selective co-inhibition of cancer clones

单细胞转录组可识别针对癌症克隆的选择性共抑制患者定制疗法

Aleksandr Ianevski #, Kristen Nader #, Kyriaki Driva, Wojciech Senkowski, Daria Bulanova, Lidia Moyano-Galceran, Tanja Ruokoranta, Heikki Kuusanmäki, Nemo Ikonen, Philipp Sergeev, Markus Vähä-Koskela, Anil K Giri, Anna Vähärautio, Mika Kontro, Kimmo Porkka, Esa Pitkänen, Caroline A Heckman, Krister

Dual specific STAT3/5 degraders effectively block acute myeloid leukemia and natural killer/T cell lymphoma

双特异性STAT3/5降解剂可有效阻断急性髓系白血病和自然杀伤/T细胞淋巴瘤。

Pölöske, Daniel; Sorger, Helena; Schönbichler, Anna; de Araujo, Elvin D; Neubauer, Heidi A; Orlova, Anna; Timonen, Sanna H; Abdallah, Diaaeldin I; Ianevski, Aleksandr; Kuusanmäki, Heikki; Surbek, Marta; Heyes, Elisabeth; Eder, Thomas; Wagner, Christina; Suske, Tobias; Metzelder, Martin L; Bergmann, Michael; Dahlhoff, Maik; Grebien, Florian; Fleck, Roman; Pirker, Christine; Berger, Walter; Hadzijusufovic, Emir; Sperr, Wolfgang R; Kenner, Lukas; Valent, Peter; Aittokallio, Tero; Herling, Marco; Mustjoki, Satu; Gunning, Patrick T; Moriggl, Richard