Design, synthesis and evaluation of acetylcholine-antitumor lipid hybrids led to identification of a potential anticancer agent disrupting the CDK4/6-Rb pathway in lung cancer
通过设计、合成和评估乙酰胆碱-抗肿瘤脂质杂合物,我们发现了一种潜在的抗癌药物,该药物能够干扰肺癌中的 CDK4/6-Rb 通路。
期刊:RSC Medicinal Chemistry
影响因子:3.6
doi:10.1039/d4md01007h
Hassan, Ahmed H E; Bae, Eun Seo; Jeong, Youngdo; Ock, Chae Won; El-Sayed, Selwan M; Kim, Minji; Radwan, Mohamed F; Ibrahim, Tarek S; Cho, Jun-Young; Park, Boyoung Y; Sim, Jaehoon; Lee, Sang Kook; Lee, Yong Sup