日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The Degradation of Botulinum Neurotoxin Light Chains Using PROTACs

利用PROTACs降解肉毒杆菌神经毒素轻链

Tsai, Yien Che; Kozar, Loren; Mawi, Zo P; Ichtchenko, Konstantin; Shoemaker, Charles B; McNutt, Patrick M; Weissman, Allan M

Co-administration of an effector antibody enhances the half-life and therapeutic potential of RNA-encoded nanobodies

效应抗体的共同给药可增强 RNA 编码纳米抗体的半衰期和治疗潜力

Moritz Thran, Marion Pönisch, Hillary Danz, Nigel Horscroft, Konstantin Ichtchenko, Saul Tzipori, Charles B Shoemaker

Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies

使用单域抗体探索肉毒杆菌毒素蛋白酶结构域的结构和功能

Kwok-Ho Lam, Jacqueline M Tremblay, Kay Perry, Konstantin Ichtchenko, Charles B Shoemaker, Rongsheng Jin

Yeast Display Enables Identification of Covalent Single-Domain Antibodies against Botulinum Neurotoxin Light Chain A

酵母展示技术可用于鉴定针对肉毒杆菌神经毒素轻链A的共价单域抗体

Alcala-Torano, Rafael; Islam, Mariha; Cika, Jaclyn; Lam, Kwok Ho; Jin, Rongsheng; Ichtchenko, Konstantin; Shoemaker, Charles B; Van Deventer, James A

Neuronal delivery of antibodies has therapeutic effects in animal models of botulism

在肉毒杆菌中毒动物模型中,通过神经元递送抗体具有治疗效果。

Patrick M McNutt ,Edwin J Vazquez-Cintron ,Luis Tenezaca ,Celinia A Ondeck ,Kyle E Kelly ,Mark Mangkhalakhili ,James B Machamer ,Christopher A Angeles ,Elliot J Glotfelty ,Jaclyn Cika ,Cesar H Benjumea ,Justin T Whitfield ,Philip A Band ,Charles B Shoemaker ,Konstantin Ichtchenko

Activity-dependent somatodendritic dopamine release in the substantia nigra autoinhibits the releasing neuron

黑质中活动依赖性的躯体树突多巴胺释放会自动抑制释放神经元

Takuya Hikima, Christian R Lee, Paul Witkovsky, Julia Chesler, Konstantin Ichtchenko, Margaret E Rice

Camelid VHH Antibodies that Neutralize Botulinum Neurotoxin Serotype E Intoxication or Protease Function

骆驼科动物 VHH 抗体可中和 E 型肉毒杆菌毒素中毒或蛋白酶功能

Jacqueline M Tremblay, Edwin Vazquez-Cintron, Kwok-Ho Lam, Jean Mukherjee, Daniela Bedenice, Celinia A Ondeck, Matthieu T Conroy, Skylar M L Bodt, Brittany M Winner, Robert P Webb, Konstantin Ichtchenko, Rongsheng Jin, Patrick M McNutt, Charles B Shoemaker

Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery

将肉毒杆菌神经毒素C1改造为神经元内药物递送的分子载体

Edwin J Vazquez-Cintron ,Phillip H Beske ,Luis Tenezaca ,Bao Q Tran ,Jonathan M Oyler ,Elliot J Glotfelty ,Christopher A Angeles ,Aurelia Syngkon ,Jean Mukherjee ,Suzanne R Kalb ,Philip A Band ,Patrick M McNutt ,Charles B Shoemaker ,Konstantin Ichtchenko

Pre-Clinical Study of a Novel Recombinant Botulinum Neurotoxin Derivative Engineered for Improved Safety

一项旨在提高安全性的新型重组肉毒杆菌神经毒素衍生物的临床前研究

Vazquez-Cintron, Edwin; Tenezaca, Luis; Angeles, Christopher; Syngkon, Aurelia; Liublinska, Victoria; Ichtchenko, Konstantin; Band, Philip

Atoxic derivative of botulinum neurotoxin A as a prototype molecular vehicle for targeted delivery to the neuronal cytoplasm

肉毒杆菌毒素 A 的无毒衍生物作为原型分子载体,用于靶向递送至神经元细胞质

Edwin J Vazquez-Cintron, Maksim Vakulenko, Philip A Band, Larry H Stanker, Eric A Johnson, Konstantin Ichtchenko