日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multimodal spatial-omics reveal co-evolution of alveolar progenitors and proinflammatory niches in progression of lung precursor lesions.

多模态空间组学揭示了肺泡祖细胞和促炎微环境在肺部前体病变进展中的共同进化。

Peng Fuduan, Sinjab Ansam, Dai Yibo, Treekitkarnmongkol Warapen, Yang Sujuan, Gomez Bolanos Lorena I, Zhou Tieling, Chen Minyue, Serrano Alejandra G, Krishna Avantika, Karimi Nastaran, Sharma Manvi, Basi Akshay, Pei Guangsheng, Liao Jianlong, Liu Yunhe, Feng Jiping, Rahal Zahraa, Liu Yang, Jiang Jiahui, Yu Kai, Noun Tala, Liu Yuejiang, Khan Khaja, Cho Kyung Serk, Chen Jichao, Solis Luisa M, Mazzilli Sarah, Dubinett Steven, Cascone Tina, Spira Avrum E, Swisher Stephen, Jimbo Naoe, Hayashi Takuo, Kishikawa Satsuki, Takamochi Kazuya, Itoh Tomoo, Yao Takashi, Suzuki Kenji, Kalhor Neda, Wistuba Ignacio I, Li Mingyao, Moghaddam Seyed Javad, Fujimoto Junya, Burks Jared, Myers Jeffrey, Akdemir Kadir, Wang Linghua, Kadara Humam

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

空间分析揭示了小鼠肺腺癌前病变在致癌物暴露与否下的分子和免疫演变差异

Zhu, Bo; Aminu, Muhammad; Chen, Pingjun; Li, Jian-Rong; Dong, Chuanpeng; Li, Chenyang; Tian, Yanhua; Lu, Shao-Wei; Chen, Hong; Ma, Chenxi; Hu, Xin; Ye, Jie; Liu, Andrew Y; Huang, Beibei; Rojas, Frank R; Roger, Parra Cuentas Edwin; Shi, Ou; Nilsson, Monique B; Poteete, Alissa; Khan, Khaja B; Lu, Wei; Solis Soto, Luisa M; Fujimoto, Junya; Haymaker, Cara; Wistuba, Ignacio I; Wei, Zhubo; Wang, Linghua; Gibbons, Don L; Chen, Ken; Reuben, Alexandre; Schenkel, Jason M; Heymach, John V; Cheng, Chao; Wu, Jia; Zhang, Jianjun

Syndecan-1-targeted therapeutic antibody impairs macropinocytosis and elicits antitumor immunity in pancreatic cancer

靶向 Syndecan-1 的治疗性抗体可抑制巨胞饮作用,并在胰腺癌中诱导抗肿瘤免疫。

Zecheng Yang,Madelaine S Theardy,Shuaitong Chen,Yongkun Wei,Mitsunobu Takeda,Yue Zeng,Xiaofei Wang,Jun Yao,Jennifer Li,Prapassorn Thirasastr,Jangho Park,Yangxi Zheng,Long T Vien,Khalida M Wani,Huamin Wang,Sisi Gao,Tim Heffernan,Lawrence Kwong,Ignacio I Wistuba,Laura Bover,Giulio F Draetta,Haoqiang Ying,Wantong Yao

Spatial and multiomics analysis of human and mouse lung adenocarcinoma precursors reveals TIM-3 as a putative target for precancer interception

对人和小鼠肺腺癌前体细胞的空间和多组学分析表明,TIM-3 是癌前阻断的潜在靶点。

Bo Zhu ,Pingjun Chen ,Muhammad Aminu ,Jian-Rong Li ,Junya Fujimoto ,Yanhua Tian ,Lingzhi Hong ,Hong Chen ,Xin Hu ,Chenyang Li ,Natalie Vokes ,Andre L Moreira ,Don L Gibbons ,Luisa M Solis Soto ,Edwin Roger Parra Cuentas ,Ou Shi ,Songhui Diao ,Jie Ye ,Frank R Rojas ,Eduardo Vilar ,Anirban Maitra ,Ken Chen ,Nicolas Navin ,Monique Nilsson ,Beibei Huang ,Simon Heeke ,Jianhua Zhang ,Cara L Haymaker ,Vamsidhar Velcheti ,Daniel H Sterman ,Veena Kochat ,William I Padron ,Ludmil B Alexandrov ,Zhubo Wei ,Xiuning Le ,Linghua Wang ,Junya Fukuoka ,J Jack Lee ,Ignacio I Wistuba ,Harvey I Pass ,Mark Davis ,Samir Hanash ,Chao Cheng ,Steven Dubinett ,Avrum Spira ,Kunal Rai ,Scott M Lippman ,P Andrew Futreal ,John V Heymach ,Alexandre Reuben ,Jia Wu ,Jianjun Zhang

Author Correction: CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

作者更正:CTLA4阻断可消除KEAP1/STK11相关的PD-(L)1抑制剂耐药性

Skoulidis, Ferdinandos; Araujo, Haniel A; Do, Minh Truong; Qian, Yu; Sun, Xin; Cobo, Ana Galan; Le, John T; Montesion, Meagan; Palmer, Rachael; Jahchan, Nadine; Juan, Joseph M; Min, Chengyin; Yu, Yi; Pan, Xuewen; Arbour, Kathryn C; Vokes, Natalie; Schmidt, Stephanie T; Molkentine, David; Owen, Dwight H; Memmott, Regan; Patil, Pradnya D; Marmarelis, Melina E; Awad, Mark M; Murray, Joseph C; Hellyer, Jessica A; Gainor, Justin F; Dimou, Anastasios; Bestvina, Christine M; Shu, Catherine A; Riess, Jonathan W; Blakely, Collin M; Pecot, Chad V; Mezquita, Laura; Tabbó, Fabrizio; Scheffler, Matthias; Digumarthy, Subba; Mooradian, Meghan J; Sacher, Adrian G; Lau, Sally C M; Saltos, Andreas N; Rotow, Julia; Johnson, Rocio Perez; Liu, Corinne; Stewart, Tyler; Goldberg, Sarah B; Killam, Jonathan; Walther, Zenta; Schalper, Kurt; Davies, Kurtis D; Woodcock, Mark G; Anagnostou, Valsamo; Marrone, Kristen A; Forde, Patrick M; Ricciuti, Biagio; Venkatraman, Deepti; Van Allen, Eliezer M; Cummings, Amy L; Goldman, Jonathan W; Shaish, Hiram; Kier, Melanie; Katz, Sharyn; Aggarwal, Charu; Ni, Ying; Azok, Joseph T; Segal, Jeremy; Ritterhouse, Lauren; Neal, Joel W; Lacroix, Ludovic; Elamin, Yasir Y; Negrao, Marcelo V; Le, Xiuning; Lam, Vincent K; Lewis, Whitney E; Kemp, Haley N; Carter, Brett; Roth, Jack A; Swisher, Stephen; Lee, Richard; Zhou, Teng; Poteete, Alissa; Kong, Yifan; Takehara, Tomohiro; Paula, Alvaro Guimaraes; Parra Cuentas, Edwin R; Behrens, Carmen; Wistuba, Ignacio I; Zhang, Jianjun; Blumenschein, George R; Gay, Carl; Byers, Lauren A; Gibbons, Don L; Tsao, Anne; Lee, J Jack; Bivona, Trever G; Camidge, D Ross; Gray, Jhannelle E; Leighl, Natasha B; Levy, Benjamin; Brahmer, Julie R; Garassino, Marina C; Gandara, David R; Garon, Edward B; Rizvi, Naiyer A; Scagliotti, Giorgio Vittorio; Wolf, Jürgen; Planchard, David; Besse, Benjamin; Herbst, Roy S; Wakelee, Heather A; Pennell, Nathan A; Shaw, Alice T; Jänne, Pasi A; Carbone, David P; Hellmann, Matthew D; Rudin, Charles M; Albacker, Lee; Mann, Helen; Zhu, Zhou; Lai, Zhongwu; Stewart, Ross; Peters, Solange; Johnson, Melissa L; Wong, Kwok K; Huang, Alan; Winslow, Monte M; Rosen, Michael J; Winters, Ian P; Papadimitrakopoulou, Vassiliki A; Cascone, Tina; Jewsbury, Philip; Heymach, John V

TREM2 Depletion in Pancreatic Cancer Elicits Pathogenic Inflammation and Accelerates Tumor Progression via Enriching IL-1β(+) Macrophages.

胰腺癌中 TREM2 的缺失会引发致病性炎症,并通过富集 IL-1β(+) 巨噬细胞加速肿瘤进展

Yang Daowei, Sun Xinlei, Wang Hua, Wistuba Ignacio I, Wang Huamin, Maitra Anirban, Chen Yang

Machine-learning driven strategies for adapting immunotherapy in metastatic NSCLC

机器学习驱动的转移性非小细胞肺癌免疫疗法调整策略

Saad, Maliazurina B; Al-Tashi, Qasem; Hong, Lingzhi; Verma, Vivek; Li, Wentao; Boiarsky, Daniel; Li, Shenduo; Petranovic, Milena; Wu, Carol C; Carter, Brett W; Shroff, Girish S; Cascone, Tina; Le, Xiuning; Elamin, Yasir Y; Altan, Mehmet; Heeke, Simon; Sheshadri, Ajay; Chang, Joe Y; Lee, Percy P; Liao, Zhongxing; Gibbons, Don L; Vaporciyan, Ara A; Lee, J Jack; Wistuba, Ignacio I; Haymaker, Cara; Mirjalili, Seyedali; Jaffray, David; Gainor, Justin F; Lou, Yanyan; Di Federico, Alessandro; Pecci, Federica; Awad, Mark; Ricciuti, Biagio; Heymach, John V; Vokes, Natalie I; Zhang, Jianjun; Wu, Jia

Nivolumab plus ipilimumab induce hyper-progression in renal medullary carcinoma: results of a phase II trial and preclinical evidence.

纳武利尤单抗联合伊匹木单抗可诱导肾髓质癌超进展:II期试验结果和临床前证据。

Soeung Melinda, Yan Xinmiao, Zanca Ciro, Qian Jing, Karki Menuka, Duan Fei, Khan Hania, Zhang Li, Peng David H, Williams Mariah, He Rong, Chen Ziheng, Perelli Luigi, Chen Jianfeng, Tidwell Rebecca S, Chauhan Pankaj K, Le Courtney N, Lam Truong N A, Bhattacharya Nirjar, Shah Rutvi, Ho I-Lin, Gay Jason P, Carrillo Caroline C, Feng Ningping, Le Kang, Gao Guang, Perry Teresa L, Mseeh Faika, Jiang Yongying, Xu Quanyun A, Zacharias Niki Marie, Sheth Rahul A, Bathala Tharakeswara K, Rao Priya, Daw Najat C, Tripathi Durga N, Walker Cheryl L, Mohammad Mohammad M, Zhang Jianhua, Han Guangchun, Chu Yanshuo, Wang Ruiping, Dang Minghao, Dai Enyu, Peng Fuduan, Liu Yunhe, Jadhav Akshaya, Lang Wenhua, Arrechedera Claudio A, Clemente Leticia Campos, Parra Edwin R, Lu Hsinyi, Haymaker Cara L, Wistuba Ignacio I, Futreal Andrew, Viale Andrea, Soth Michael J, Jones Philip, Marszalek Joseph R, Heffernan Timothy, Draetta Giulio F, Tannir Nizar M, Gao Jianjun, Wang Linghua, Genovese Giannicola, Msaouel Pavlos

The mutational landscape and functional effects of noncoding ultraconserved elements in human cancers

人类癌症中非编码超保守元件的突变图谱及其功能效应

Bayraktar, Recep; Tang, Yitao; Dragomir, Mihnea P; Ivan, Cristina; Peng, Xinxin; Fabris, Linda; Zhang, Jianhua; Carugo, Alessandro; Aneli, Serena; Liu, Jintan; Chen, Mei-Ju M; Srinivasan, Sanjana; Sahnoune, Iman; Bayraktar, Emine; Akdemir, Kadir C; Chen, Meng; Narayanan, Pranav; Huang, Wilson; Ott, Leonie Florence; Eterovic, Agda Karina; Villarreal, Oscar Eduardo; Mohammad, Mohammad Moustaf; Peoples, Michael D; Walsh, Danielle M; Hernandez, Jon Andrew; Morgan, Margaret B; Shaw, Kenna R; Davis, Jennifer S; Menter, David; Tam, Constantine S; Yeh, Paul; Dawson, Sarah-Jane; Rassenti, Laura Z; Kipps, Thomas J; Kunej, Tanja; Estrov, Zeev; Joosse, Simon A; Pagani, Luca; Alix-Panabières, Catherine; Pantel, Klaus; Ferajoli, Alessandra; Futreal, Andrew; Wistuba, Ignacio I; Radovich, Milan; Kopetz, Scott; Keating, Michael J; Draetta, Giulio F; Mattick, John S; Liang, Han; Calin, George A

The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer

整合应激反应通路协调肺癌中多个免疫检查点的转化控制

Shayna Thomas-Jardin ,Shruthy Suresh ,Ariana Arce ,Nicole Novaresi ,Qing Deng ,Emily Stein ,Lisa Thomas ,Cheryl Lewis ,Chul Ahn ,Bret M Evers ,Esra A Akbay ,Maria E Salvatierra ,Wei Lu ,Khaja Khan ,Luisa M Solis Soto ,Ignacio I Wistuba ,John D Minna ,Kathryn A O'Donnell