日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Night vision restored in days after decades of congenital blindness

先天性失明数十年后,夜视能力在几天内恢复

Samuel G Jacobson, Artur V Cideciyan, Allen C Ho, Alejandro J Roman, Vivian Wu, Alexandra V Garafalo, Alexander Sumaroka, Arun K Krishnan, Malgorzata Swider, Abraham A Mascio, Christine N Kay, Dan Yoon, Kenji P Fujita, Sanford L Boye, Igor V Peshenko, Alexander M Dizhoor, Shannon E Boye

Retinal degeneration-3 protein attenuates photoreceptor degeneration in transgenic mice expressing dominant mutation of human retinal guanylyl cyclase

视网膜变性-3蛋白减轻表达人类视网膜鸟苷酸环化酶显性突变的转基因小鼠的光感受器变性

Igor V Peshenko, Elena V Olshevskaya, Alexander M Dizhoor

A G86R mutation in the calcium-sensor protein GCAP1 alters regulation of retinal guanylyl cyclase and causes dominant cone-rod degeneration

钙传感器蛋白 GCAP1 的 G86R 突变会改变视网膜鸟苷酸环化酶的调节并导致显性视锥细胞-视杆细胞变性

Igor V Peshenko, Artur V Cideciyan, Alexander Sumaroka, Elena V Olshevskaya, Alexander Scholten, Seher Abbas, Karl-Wilhelm Koch, Samuel G Jacobson, Alexander M Dizhoor

Retinal guanylyl cyclase activation by calcium sensor proteins mediates photoreceptor degeneration in an rd3 mouse model of congenital human blindness

钙传感蛋白激活视网膜鸟苷酸环化酶介导人类先天性失明 rd3 小鼠模型中的光感受器变性

Alexander M Dizhoor, Elena V Olshevskaya, Igor V Peshenko

Guanylate cyclase-activating protein 2 contributes to phototransduction and light adaptation in mouse cone photoreceptors

鸟苷酸环化酶活化蛋白 2 有助于小鼠视锥细胞的光转导和光适应

Frans Vinberg, Igor V Peshenko, Jeannie Chen, Alexander M Dizhoor, Vladimir J Kefalov

Gene Therapy Fully Restores Vision to the All-Cone Nrl(-/-) Gucy2e(-/-) Mouse Model of Leber Congenital Amaurosis-1

基因疗法完全恢复 Leber 先天性黑蒙-1 的全锥 Nrl(-/-) Gucy2e(-/-) 小鼠模型的视力

Sanford L Boye, James J Peterson, Shreyasi Choudhury, Seok Hong Min, Qing Ruan, K Tyler McCullough, Zhonghong Zhang, Elena V Olshevskaya, Igor V Peshenko, William W Hauswirth, Xi-Qin Ding, Alexander M Dizhoor, Shannon E Boye

cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function

cGMP 积累导致 CNG 通道缺陷中的光感受器变性:cGMP 细胞毒性的证据独立于增强的 CNG 通道功能

Jianhua Xu, Lynsie Morris, Arjun Thapa, Hongwei Ma, Stylianos Michalakis, Martin Biel, Wolfgang Baehr, Igor V Peshenko, Alexander M Dizhoor, Xi-Qin Ding

AAV-mediated gene therapy in the guanylate cyclase (RetGC1/RetGC2) double knockout mouse model of Leber congenital amaurosis

AAV 介导的莱伯先天性黑蒙症鸟苷酸环化酶 (RetGC1/RetGC2) 双敲除小鼠模型基因治疗

Sanford L Boye, Igor V Peshenko, Wei Chieh Huang, Seok Hong Min, Issam McDoom, Christine N Kay, Xuan Liu, Frank M Dyka, Thomas C Foster, Yumiko Umino, Sukanya Karan, Samuel G Jacobson, Wolfgang Baehr, Alexander Dizhoor, William W Hauswirth, Shannon E Boye