日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Efficacy and Imaging-Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer

KRAS G12C抑制剂在异种移植和基因工程小鼠癌症模型中的疗效及影像辅助药效学分析

期刊:Molecular Cancer Therapeutics
影响因子:5.5
doi:10.1158/1535-7163.MCT-22-0810
Lee, Catherine; Jiang, Ziyue Karen; Planken, Simon; Manzuk, Lisa K; Ortiz, Roberto; Hall, Michael; Noorbehesht, Kavon; Ram, Sripad; Affolter, Timothy; Troche, Gabriel E; Ihle, Nathan T; Johnson, Theodore; Ahn, Youngwook; Kraus, Manfred; Giddabasappa, Anand
RAS
肿瘤
Mouse
肿瘤免疫
发表日期：2023
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Outlier analysis of functional genomic profiles enriches for oncology targets and enables precision medicine

对功能基因组谱进行异常值分析，可以富集肿瘤靶点，并实现精准医疗。

期刊:BMC Genomics
影响因子:3.7
doi:10.1186/s12864-016-2807-y
Zhu, Zhou; Ihle, Nathan T; Rejto, Paul A; Zarrinkar, Patrick P
肿瘤
肿瘤免疫
发表日期：2016
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Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome.

KRAS癌基因替换对蛋白质行为的影响：对信号传导和临床结果的意义

期刊:Jnci-Journal of the National Cancer Institute
影响因子:7.2
doi:10.1093/jnci/djr523
Ihle Nathan T, Byers Lauren A, Kim Edward S, Saintigny Pierre, Lee J Jack, Blumenschein George R, Tsao Anne, Liu Suyu, Larsen Jill E, Wang Jing, Diao Lixia, Coombes Kevin R, Chen Lu, Zhang Shuxing, Abdelmelek Mena F, Tang Ximing, Papadimitrakopoulou Vassiliki, Minna John D, Lippman Scott M, Hong Waun K, Herbst Roy S, Wistuba Ignacio I, Heymach John V, Powis Garth
信号转导
肿瘤免疫
发表日期：2012
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Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy

服用PIK：磷脂酰肌醇3-激酶抑制剂正迅速通过临床试验，迈向癌症治疗领域。

期刊:Molecular Cancer Therapeutics
影响因子:5.5
doi:10.1158/1535-7163.MCT-08-0801
Ihle, Nathan T; Powis, Garth
信号转导
肿瘤
肿瘤免疫
发表日期：2009
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Peroxisome proliferator-activated receptor gamma agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without affecting antitumor activity

过氧化物酶体增殖物激活受体γ激动剂吡格列酮可预防由PX-866抑制磷脂酰肌醇3-激酶通路引起的血糖升高，且不影响其抗肿瘤活性。

期刊:Molecular Cancer Therapeutics
影响因子:5.5
doi:10.1158/1535-7163.MCT-08-0714
Ihle, Nathan T; Lemos, Robert; Schwartz, David; Oh, Junghwan; Halter, Robert J; Wipf, Peter; Kirkpatrick, Lynn; Powis, Garth
信号转导
肿瘤
肿瘤免疫
发表日期：2009
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The skin and hair as surrogate tissues for measuring the target effect of inhibitors of phosphoinositide-3-kinase signaling

以皮肤和毛发作为替代组织来测量磷脂酰肌醇-3-激酶信号通路抑制剂的靶效应

期刊:Cancer Chemotherapy and Pharmacology
影响因子:2.3
doi:10.1007/s00280-006-0190-0
Williams, Ryan; Baker, Amanda F; Ihle, Nathan T; Winkler, Ashley R; Kirkpatrick, Lynn; Powis, Garth
信号转导
发表日期：2006
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