日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Entorhinal Cortex Wolframin-1-expressing neurons propagate tau to CA1 neurons and impair hippocampal memory

内嗅皮层中表达 Wolframin-1 的神经元会将 tau 蛋白传播至 CA1 神经元,并损害海马记忆。

Delpech, Jean-Christophe; Kalavai, Srinidhi Venkatesan; Pathak, Dhruba; Ravula, Arun Reddy; Lad, Heena V; Hays, Emma C; Touch, Nina; Rau, Andrea; Madore, Charlotte; Medalla, Maria; Luebke, Jennifer I; Ikezu, Seiko; Ikezu, Tsuneya

Proteomic characterization of neuronal extracellular vesicle interactomes in Alzheimer's disease mouse model through TurboID-based proximity labeling

利用基于TurboID的邻近标记技术对阿尔茨海默病小鼠模型中神经元细胞外囊泡相互作用组进行蛋白质组学表征

Gibbs, Brendan J; Chen, Yunfei; Abdullah, Mohammad; Nguyen, SonNgoc; McQuaker-Kajiwara, James; Melvin, Bridgette; Longtree-Preciado, Alejandro; Liang, Zhewei; Gonzalez-Perez, Maria Paz; Ikezu, Seiko; Ikezu, Tsuneya

Unique lipid cargoes in APOE4 human brain-derived extracellular vesicles recruit cell adhesion molecules and promote tauopathy in Alzheimer's disease.

APOE4 人类大脑来源的细胞外囊泡中独特的脂质货物可募集细胞粘附分子,并促进阿尔茨海默病中的 tau 蛋白病变

Ikezu Tsuneya, Zhang Zhengrong, Yu Kaiwen, Bao Hanmei, Ikezu Tadafumi, Ravula Arun Reddy, Melvin Bridgette, Scholes Clara, You Yang, Ellison Justice, Kanekiyo Takahisa, Wszolek Zbigniew, DeTure Michael, Dickson Dennis, Han Xianlin, Peng Junmin, Ikezu Seiko

P2RX7 regulates tauopathy progression via tau and mitochondria loading in extracellular vesicles.

P2RX7 通过细胞外囊泡中 tau 蛋白和线粒体的装载来调节 tau 蛋白病的进展

Ikezu Tsuneya, Bodart-Santos Victor, Ravula Arun Reddy, You Yang, Abdullah Mohammad, Ruan Zhi, Ellison Justice, Radhakishun Stephanie, Ray Nibedita Basu, Melvin Bridgette, Kurti Aishe, Liang Zhewei, Sakai Yuta, O'Brien Daniel, Nguyen Son, Shaffer Scott, Fiddes Lindsey, Butovsky Oleg, Springer Wolfdieter, Ikezu Seiko

The P301L tau mutation alters extracellular vesicle biogenesis in astrocyte and contributes to astrocyte‐mediated tau pathology in a human iPSC‐derived model of tauopathies

P301L tau 突变会改变星形胶质细胞中的细胞外囊泡生物合成,并在人类 iPSC 衍生的 tau 蛋白病模型中导致星形胶质细胞介导的 tau 蛋白病理。

Soto-Ortolaza, Alexandra I; Ross, Owen A; Atik, Merve; Reddy, Joseph S; Nguyen, Thuy; Sotelo, Katie D; Q, Frederick; Minerva, M; Carrasquillo; Graff-Radford, Jonathan; R, Neil; Graff-Radford; Kantarci, Kejal; DeTure, Michael; Dickson, Dennis W; Allen, Mariet; Ertekin-Taner, Nilüfer; Aduen, Paula; Badillo‐Cabrera, Alex L; Vila‐Castelar, Clara; Noriega‐Makarskyy, Daisy; Munera, Diana; Lucas, John A; Kirschbaum, Clemens; Slavich, George M; Quiroz, Yakeel T; Raulin, Ana‐Caroline; Linares, Cynthia; Alnobani, Alla; Roy, Bhaskar; Crow, Ailsa; Doss, Sydney V; Kuchenbecker, Lindsey A; Dacquel, Maxwell V; Karch, Celeste M; Martens, Yuka A; Liu, Chia‐Chen; Bu, Guojun; Kanekiyo, Takahisa; Patel, Henika; Martinez, Pablo; Lopes, Daniella; Jury, Nur; Vanderbosch, Katie; You, Yanwen; Kouri, Naomi; Rothberg, Darren M; Yaguchi, Hiroaki; Tanaka, Shinya; Wakabayashi, Koichi; Yabe, Ichiro; Murray, Melissa E; Reeves, Cristian A Lasagna; You, Yang; Mann, Sean D Jr; Lu, Wenyan; Poon, Wayne W; Ikezu, Seiko; Kanekiyo, Takahisa; Dickson, Dennis W; Sławek, Jarosaw; Wszolek, Zbigniew; Ikezu, Tsuneya

P2RX7 deficiency prevents cognitive deficit, brain atrophy and tauopathy progression in PS19 mice via suppression of extracellular vesicle secretion and mitochondrial toxicity

P2RX7 缺陷通过抑制细胞外囊泡分泌和线粒体毒性,阻止 PS19 小鼠出现认知缺陷、脑萎缩和 tau 蛋白病变进展。

Baker, Emily; Leonenko, Ganna; Schmidt, Karl Michael; Hill, Matthew; Myers, Amanda J; Shoai, Maryam; de Rojas, Itziar; Tesi, Niccoló; Holstege, Henne; van der Flier, Wiesje M; Pijnenburg, Yolande A L; Ruiz, Agustin; Hardy, John; van der Lee, Sven; Escott-Price, Valentina; Borna, Sahar; Gomez-Cabello, Cesar A; Ali Haider, Syed; Genovese, Ariana; Prabha, Srinivasagam; Trabilsy, Maissa; Haider, Clifton R; Felton, Christopher L; Carter, Rickey E; McLeod, Christopher J; Bruce, Charles J; Jorge Forte, Antonio; WANG, NA; Doss, Sydney V; Chang, Yuzhou; Tauer, William; Ren, Yingxue; Qi, Fangfang; Bu, Guojun; Liu, Chia‐Chen; Wu, Long‐Jun; Santos, Victor B; Abdullah, Mohammad; Ellison, Justice; Ruan, Zhi; Ikezu, Tsuneya; Ikezu, Seiko

Rostral locus coeruleus metabolism relates to Alzheimer's disease pathology and cognition in amyloid‐positive symptomatic individuals

蓝斑前部代谢与淀粉样蛋白阳性症状患者的阿尔茨海默病病理和认知功能相关

Liu, Qing Yan; Chang, Marilyn N Vera; Lei, Joy X; Koukiekolo, Roger; Smith, Brandon; Zhang, Dongling; Ghribi, Othman; Ikezu, Tsuneya; Zhang, Zhengrong; You, Yang; Yu, Kaiwen; Ravula, Arun Reddy; Chen, Yunfei I; Melvin, Bridgette; Longtree‐Preciado, Alejandro; Ikezu, Seiko; DeTure, Michael A; Dickson, Dennis W; Peng, Junmin; Rizzi, Liara; Oh, Ian Michael; Li, Song Hua; Pereira, Felipe Luiz; Grinberg, Lea T; Bechke, Emily; Park, Kyoung Shin; Wideman, Laurie; Anderson, Travis; Goldenstein, Samantha J; Slutsky‐Ganesh, Alexis B; Armstrong, Brittany D; Etnier, Jennifer L; Koops, Elouise A; Dutta, Joyita; Becker, Alex; Hanseeuw, Bernard J; Sperling, Reisa A; Johnson, Keith A; Jacobs, Heidi IL; Koops, Elouise A; Dutta, Joyita; Becker, Alex; Hanseeuw, Bernard J; Sperling, Reisa A; Johnson, Keith A; Jacobs, Heidi IL

Microglial WNT5A supports dendritic spines maturation and neuronal firing

小胶质细胞 WNT5A 支持树突棘成熟和神经元放电

Hana Yeh, Maya E Woodbury, Kaitlin L Ingraham Dixie, Tsuneya Ikezu, Seiko Ikezu

Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice

基于反义寡核苷酸的 Tau-微管蛋白激酶 1 靶向治疗可防止 PS19 tau 病小鼠海马中磷酸化 tau 的积累

Kayo Yukawa, Satomi Yamamoto-Mcguire, Louis Cafaro, Christine Hong, Fredrik Kamme, Tsuneya Ikezu, Seiko Ikezu

P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice

P2RX7抑制剂可抑制P301S tau转基因小鼠的外泌体分泌和疾病表型

Ruan, Zhi; Delpech, Jean-Christophe; Venkatesan Kalavai, Srinidhi; Van Enoo, Alicia A; Hu, Jianqiao; Ikezu, Seiko; Ikezu, Tsuneya