日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

YIAD-0501 directly dissociates aggregates of full-length and N-terminal pyroglutamate-modified forms of Aβ.

YIAD-0501 直接解离全长和 N 端焦谷氨酸修饰形式的 Aβ 的聚集体。

Shin Heewon, Lee Sunhee, Seo Wonbin, Yoon Seok Hyun, Cho Illhwan, Ye Suhyun, Park InWook, Yoon Soljee, Park MinSeol, Kim Sunghyun, Lee Songmin, Kim Hye Yun, Kim Ikyon, Kim YoungSoo

Anticancer Evaluation of Novel Benzofuran-Indole Hybrids as Epidermal Growth Factor Receptor Inhibitors against Non-Small-Cell Lung Cancer Cells

新型苯并呋喃-吲哚杂合物作为表皮生长因子受体抑制剂对非小细胞肺癌细胞的抗癌活性评价

Lee, Yechan; Lee, Sunhee; Lee, Younho; Song, Doona; Park, So-Hyeon; Kim, Jieun; Namkung, Wan; Kim, Ikyon

Divergent Annulation Modes of (Z)-4-Aryl-4-oxo-2-(pyridin-2-yl)but-2-enenitrile and Methyl Nitroacetate: Selective Access to 2-Acyl-4H-quinolizin-4-one, Isoxazole, and 2-Acylindolizine

(Z)-4-芳基-4-氧代-2-(吡啶-2-基)丁-2-烯腈与硝基乙酸甲酯的不同环化模式:选择性合成2-酰基-4H-喹诺嗪-4-酮、异噁唑和2-酰基吲哚嗪

Lee, Sunhee; Kim, Woojin; Kim, Ikyon

Aryloxypropanolamine mitigates Alzheimer‐like phenotype by directly removing amyloid aggregates

芳氧基丙醇胺通过直接清除淀粉样蛋白聚集体来减轻阿尔茨海默病样表型。

Wu, Hongmin; Sawada, Takumi; Goto, Takafumi; Yoneyama, Tatsuya; Sasano, Tetsuo; Asada, Ken; Yoon, Soljee; Lee, Hee Yang; Cho, Illhwan; Lee, Donghee; Shin, Jisu; Kim, Kyeonghwan; Kim, Jimin; Kim, Hye Yun; Kim, Ikyon; Kim, YoungSoo

C3 Functionalization of Indolizines via HFIP-Promoted Friedel-Crafts Reactions with (Hetero)arylglyoxals

通过HFIP促进的傅克反应,利用(杂)芳基乙二醛对吲哚嗪进行C3官能化。

Jung, Euijin; Jeong, Yerin; Kim, Hyeyeon; Kim, Ikyon

Aryloxypropanolamine targets amyloid aggregates and reverses Alzheimer-like phenotypes in Alzheimer mouse models

芳氧基丙醇胺靶向淀粉样蛋白聚集体并逆转阿尔茨海默病小鼠模型中的阿尔茨海默病样表型

Hee Yang Lee #, Soljee Yoon #, Jeong Hwa Lee #, Keunwan Park, Youngeun Jung, Illhwan Cho, Donghee Lee, Jisu Shin, Kyeonghwan Kim, Sunmi Kim, Jimin Kim, Koeun Kim, Seung Hoon Han, Seong Muk Kim, Hye Ju Kim, Hye Yun Kim, Ikyon Kim, Young Soo Kim

VI-116, A Novel Potent Inhibitor of VRAC with Minimal Effect on ANO1

VI-116,一种新型强效VRAC抑制剂,对ANO1的影响极小。

Jeon, Dongkyu; Ryu, Kunhi; Jo, Sungwoo; Kim, Ikyon; Namkung, Wan

Synthesis and Biological Evaluation of a Fused Structure of Indolizine and Pyrrolo[1,2-c]pyrimidine: Identification of Its Potent Anticancer Activity against Liver Cancer Cells

吲哚嗪与吡咯并[1,2-c]嘧啶稠合结构的合成及生物学评价:鉴定其对肝癌细胞的强效抗癌活性

Nam, Seonghyeon; Lee, Yechan; Park, So-Hyeon; Namkung, Wan; Kim, Ikyon

Anti-amyloidogenic indolizino[3,2-c]quinolines as imaging probes differentiating dense-core, diffuse, and coronal plaques of amyloid-β

抗淀粉样蛋白生成吲哚嗪并[3,2-c]喹啉类化合物作为成像探针,可区分淀粉样β蛋白的致密核心斑块、弥漫斑块和冠状斑块。

Kim, Kyeonghwan; Lee, Jeong Hwa; Kim, Sunmi; Lee, Songmin; Lee, Donghee; Kim, Hye Yun; Kim, Ikyon; Kim, YoungSoo

Development of S-Methylmethionine Sulfonium Derivatives and Their Skin-Protective Effect against Ultraviolet Exposure

S-甲基蛋氨酸锍衍生物的研制及其对紫外线照射的皮肤保护作用

Kim, Won-Serk; Kim, Wang-Kyun; Choi, Nahyun; Suh, Wonhee; Lee, Jinu; Kim, Dae-Duk; Kim, Ikyon; Sung, Jong-Hyuk