Longitudinal multiomics analysis of aggressive pituitary neuroendocrine tumors: comparing primary and recurrent tumors from the same patient, reveals genomic stability and heterogeneous transcriptomic profiles with alterations in metabolic pathways

侵袭性垂体神经内分泌肿瘤的纵向多组学分析：比较同一患者的原发性肿瘤和复发性肿瘤，揭示基因组稳定性和异质性转录组谱以及代谢途径的改变