日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity

PTPN2/PTPN1抑制剂ABBV-CLS-484可释放强大的抗肿瘤免疫力。

Christina K Baumgartner # ,Hakimeh Ebrahimi-Nik # ,Arvin Iracheta-Vellve ,Keith M Hamel ,Kira E Olander ,Thomas G R Davis ,Kathleen A McGuire ,Geoff T Halvorsen ,Omar I Avila ,Chirag H Patel ,Sarah Y Kim ,Ashwin V Kammula ,Audrey J Muscato ,Kyle Halliwill ,Prasanthi Geda ,Kelly L Klinge ,Zhaoming Xiong ,Ryan Duggan ,Liang Mu ,Mitchell D Yeary ,James C Patti ,Tyler M Balon ,Rebecca Mathew ,Carey Backus ,Domenick E Kennedy ,Angeline Chen ,Kenton Longenecker ,Joseph T Klahn ,Cara L Hrusch ,Navasona Krishnan ,Charles W Hutchins ,Jax P Dunning ,Marinka Bulic ,Payal Tiwari ,Kayla J Colvin ,Cun Lan Chuong ,Ian C Kohnle ,Matthew G Rees ,Andrew Boghossian ,Melissa Ronan ,Jennifer A Roth ,Meng-Ju Wu ,Juliette S M T Suermondt ,Nelson H Knudsen ,Collins K Cheruiyot ,Debattama R Sen ,Gabriel K Griffin ,Todd R Golub ,Nabeel El-Bardeesy ,Joshua H Decker ,Yi Yang ,Magali Guffroy ,Stacey Fossey ,Patricia Trusk ,Im-Meng Sun ,Yue Liu ,Wei Qiu ,Qi Sun ,Marcia N Paddock ,Elliot P Farney ,Mark A Matulenko ,Clay Beauregard ,Jennifer M Frost # ,Kathleen B Yates # ,Philip R Kym # ,Robert T Manguso #

GOT1 regulates CD8+ effector and memory T cell generation

GOT1 调控 CD8+ 效应 T 细胞和记忆 T 细胞的生成

Wei Xu ,Chirag H Patel ,Liang Zhao ,Im-Hong Sun ,Min-Hee Oh ,Im-Meng Sun ,Rachel S Helms ,Jiayu Wen ,Jonathan D Powell

Serendipitous Discovery of T Cell-Produced KLK1b22 as a Regulator of Systemic Metabolism

偶然发现 T 细胞产生的 KLK1b22 可调节全身代谢

Matthew L Arwood, Im-Hong Sun, Chirag H Patel, Im-Meng Sun, Min-Hee Oh, Ian A Bettencourt, Michael D Claiborne, Yee Chan-Li, Liang Zhao, Adam T Waickman, Orestes Mavrothalassitis, Jiayu Wen, Susan Aja, Jonathan D Powell

Persistent CAD activity in memory CD8+ T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge

记忆 CD8+ T 细胞中持续的 CAD 活性支持再次攻击所需的 rRNA 合成和核糖体生物合成

Michael D Claiborne, Srona Sengupta, Liang Zhao, Matthew L Arwood, Im-Meng Sun, Jiayu Wen, Elizabeth A Thompson, Marisa Mitchell-Flack, Marikki Laiho, Jonathan D Powell

Cutting Edge: mTORC2 Regulates CD8+ Effector and Memory T Cell Differentiation through Serum and Glucocorticoid Kinase 1

前沿:mTORC2 通过血清和糖皮质激素激酶 1 调节 CD8+ 效应 T 细胞和记忆 T 细胞分化

Chirag H Patel, Emily B Heikamp, Wei Xu, Im-Hong Sun, Min-Hee Oh, Im-Meng Sun, Jiayu Wen, Ada J Tam, Richard L Blosser, Jonathan D Powell

Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells

靶向谷氨酰胺代谢可通过调节抑制性髓系细胞来增强肿瘤特异性免疫。

Oh, Min-Hee; Sun, Im-Hong; Zhao, Liang; Leone, Robert D; Sun, Im-Meng; Xu, Wei; Collins, Samuel L; Tam, Ada J; Blosser, Richard L; Patel, Chirag H; Englert, Judson M; Arwood, Matthew L; Wen, Jiayu; Chan-Li, Yee; Tenora, Lukáš; Majer, Pavel; Rais, Rana; Slusher, Barbara S; Horton, Maureen R; Powell, Jonathan D

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

谷氨酰胺阻断诱导不同的代谢程序以克服肿瘤免疫逃逸

Leone, Robert D; Zhao, Liang; Englert, Judson M; Sun, Im-Meng; Oh, Min-Hee; Sun, Im-Hong; Arwood, Matthew L; Bettencourt, Ian A; Patel, Chirag H; Wen, Jiayu; Tam, Ada; Blosser, Richard L; Prchalova, Eva; Alt, Jesse; Rais, Rana; Slusher, Barbara S; Powell, Jonathan D

Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models

抑制腺苷A2a受体可调节T细胞共抑制受体的表达,并改善效应功能,从而增强小鼠癌症模型中的免疫检查点阻断和过继性细胞疗法(ACT)。

Leone, Robert D; Sun, Im-Meng; Oh, Min-Hee; Sun, Im-Hong; Wen, Jiayu; Englert, Judson; Powell, Jonathan D