Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase.

早老素 1 跨膜结构域的功能分析：跨膜结构域 2 和 6 参与 γ-分泌酶初始底物结合位点的形成