日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Amino acid deletion at codon 67 and Thr-to-Gly change at codon 69 of human immunodeficiency virus type 1 reverse transcriptase confer novel drug resistance profiles

人类免疫缺陷病毒1型逆转录酶第67位密码子的氨基酸缺失以及第69位密码子苏氨酸到甘氨酸的改变赋予了该病毒新的耐药谱。

Imamichi, T; Murphy, M A; Imamichi, H; Lane, H C

Relative replication fitness of a high-level 3'-azido-3'-deoxythymidine-resistant variant of human immunodeficiency virus type 1 possessing an amino acid deletion at codon 67 and a novel substitution (Thr-->Gly) at codon 69

具有高水平3'-叠氮-3'-脱氧胸苷抗性的1型人类免疫缺陷病毒变体的相对复制适应性,该变体在第67位密码子处存在氨基酸缺失,并在第69位密码子处存在新的氨基酸替换(Thr→Gly)。

Imamichi, T; Berg, S C; Imamichi, H; Lopez, J C; Metcalf, J A; Falloon, J; Lane, H C

Resistance to replication of human immunodeficiency virus challenge in SCID-Hu mice engrafted with peripheral blood mononuclear cells of nonprogressors is mediated by CD8(+) T cells and associated with a proliferative response to p24 antigen.

在移植了非进展者外周血单核细胞的 SCID-Hu 小鼠中,对人类免疫缺陷病毒攻击的复制的抵抗力是由 CD8(+) T 细胞介导的,并且与对 p24 抗原的增殖反应有关

de Quiros J C, Shupert W L, McNeil A C, Gea-Banacloche J C, Flanigan M, Savage A, Martino L, Weiskopf E E, Imamichi H, Zhang Y M, Adelsburger J, Stevens R, Murphy P M, Zimmerman P A, Hallahan C W, Davey R T Jr, Connors M

Emergence of protease inhibitor resistance mutations in human immunodeficiency virus type 1 isolates from patients and rapid screening procedure for their detection

从患者体内分离出的1型人类免疫缺陷病毒中蛋白酶抑制剂耐药突变的出现及其快速筛查检测方法

Vasudevachari, M B; Zhang, Y M; Imamichi, H; Imamichi, T; Falloon, J; Salzman, N P