日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models.

对全球小鼠甲基化组图谱的研究揭示了儿童癌症模型中亚型特异性拷贝数改变。

Schoof Melanie, Zheng Tuyu, Sill Martin, Imle Roland, Cais Alessia, Altendorf Lea, Fürst Alicia, Hofmann Nina, Ernst Kati, Vonficht Dominik, Chan Kenneth Chun-Ho, Holland-Letz Tim, Postlmayr Andreas, Shiraishi Ryo, Wang Wanchen, Morcavallo Alaide, Spohn Michael, Göbel Carolin, Niesen Judith, Peter Levke-Sophie, Bourdeaut Franck, Han Zhi-Yan, Pei Yanxin, Murad Najiba, Swartling Fredrik J, Taylor Jessica, Yadav Monika, Gibson Garrett R, Gilbertson Richard J, Dottermusch Matthias, Roy Rajanya, Kerl Kornelius, Glass Rainer, Cheng Jiying, Horstmann Martin A, Wolters-Eisfeld Gerrit, Zhao Haotian, Sturm Dominik, Yadav Viveka Nand, Chesler Louis, Haas Simon, Weiss William A, Northcott Paul A, Kutscher Lena M, Guerreiro Stucklin Ana, Ayrault Olivier, Neumann Julia E, Kawauchi Daisuke, Jones David T W, Pajtler Kristian, Banito Ana, Pfister Stefan M, Schüller Ulrich, Zuckermann Marc

Loss of SMARCB1 evokes targetable epigenetic vulnerabilities in epithelioid sarcoma

SMARCB1 的缺失会在上皮样肉瘤中引发可靶向的表观遗传脆弱性

Jin, Jia Xiang; Fuchslocher, Fabia; Carreno-Gonzalez, Martha; Zahnow, Felina; Ceranski, A Katharina; Will, Rainer; Helm, Dominic; Bestvater, Felix; Banito, Ana; Imle, Roland; Ohmura, Shunya; Cidre-Aranaz, Florencia; Grünewald, Thomas G P

Comprehensive DSRCT multi-omics analyses unveil CACNA2D2 as a diagnostic hallmark and super-enhancer-driven EWSR1::WT1 signature gene

全面的DSRCT多组学分析揭示CACNA2D2是诊断标志物,也是由超级增强子驱动的EWSR1::WT1特征基因。

Geyer, Florian Henning; Ritter, Alina; Kinn-Gurzo, Seneca; Faehling, Tobias; Li, Jing; Jarosch, Armin; Ngo, Carine; Vinca, Endrit; Aljakouch, Karim; Orynbek, Azhar; Ohmura, Shunya; Kirchner, Thomas; Imle, Roland; Romero-Pérez, Laura; Díaz-Martín, Juan; Bertram, Stefanie; de Álava, Enrique; Henon, Clémence; Postel-Vilnay, Sophie; Banito, Ana; Sill, Martin; Versleijen-Jonkers, Yvonne; Mayer, Benjamin Friedrich Berthold; Ebinger, Martin; Sparber-Sauer, Monika; Stegmaier, Sabine; Baumhoer, Daniel; Hartmann, Wolfgang; Krijgsveld, Jeroen; Horst, David; Delattre, Olivier; Grohar, Patrick Joseph; Grünewald, Thomas Georg Phillip; Cidre-Aranaz, Florencia

Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing sarcoma.

EWSR1::FLI1 对 mRNA 降解途径的干扰是尤文氏肉瘤治疗中的一个弱点

Galvan Bartimée, Ongena Loïc, Bruyr Jonathan, Fettweis Gregory, Lucarelli Eva, Lavergne Arnaud, Mariavelle Emeline, O'Grady Tina M, Hassoun Zahrat El Oula, Claes Margaux, Dubois Laurence, Lee Kevin A W, Kruys Véronique, Gueydan Cyril, Durand Jules, Hervouet Eric, Geyer Florian H, Banito Ana, Imle Roland, Mao Lianghao, Jayavelu Ashok K, Grünewald Thomas G P, Cidre-Aranaz Florencia, Twizere Jean-Claude, Dequiedt Franck

Somatic gene delivery faithfully recapitulates a molecular spectrum of high-risk sarcomas.

体细胞基因导入能够忠实地重现高危肉瘤的分子谱

Imle Roland, Blösel Daniel, Kommoss Felix K F, Placke Sara, Stutheit-Zhao Eric, Blume Christina, Lupar Dmitry, Schmitt Lukas, Winter Claudia, Wagner Lena, von Eicke Malte, Walzer Hannah, Förderer Julia, Laier Stephanie, Hertwig Michael, Peterziel Heike, Oehme Ina, Scheuerman Sophia, Seitz Christian M, Geyer Florian H, Cidre-Aranaz Florencia, Grünewald Thomas G P, Vokuhl Christian, Chudasama Priya, Scholl Claudia, Schmidt Claudia, Günther Patrick, Sill Martin, Jones Kevin B, Pfister Stefan M, Autry Robert J, Banito Ana

High 4E-BP1 expression associates with chromosome 8 gain and CDK4/6 sensitivity in Ewing sarcoma

尤文氏肉瘤中高表达的 4E-BP1 与 8 号染色体扩增和 CDK4/6 敏感性相关

Funk, Cornelius M; Ehlers, Anna C; Orth, Martin F; Aljakouch, Karim; Li, Jing; Hölting, Tilman Lb; Will, Rainer; Geyer, Florian H; Ceranski, A Katharina; Willis, Franziska; Vinca, Endrit; Ohmura, Shunya; Imle, Roland; Siebenlist, Jana; Yershova, Angelina; Knott, Maximilian Ml; Zahnow, Felina; Sastre, Ana; Alonso, Javier; Sahm, Felix; Peterziel, Heike; Loboda, Anna; Schneider, Martin; Banito, Ana; Leprivier, Gabriel; Hartmann, Wolfgang; Dirksen, Uta; Witt, Olaf; Oehme, Ina; Pfister, Stefan M; Romero-Pérez, Laura; Krijgsveld, Jeroen; Cidre-Aranaz, Florencia; Grünewald, Thomas Gp; Musa, Julian

Acasunlimab, an Fc-inert PD-L1×4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects

Acasunlimab 是一种 Fc 惰性 PD-L1×4-1BB 双特异性抗体,与 PD-1 阻断剂联合使用可通过互补的免疫调节作用增强抗肿瘤免疫力。

Michela Capello # ,Angelica Sette # ,Theo Plantinga ,Craig J Thalhauser ,Vanessa M Spires ,Kristina B Nürmberger ,Jordan M Blum ,Brandon W Higgs ,Patricia Garrido Castro ,Christina Yu ,Carol Costa Sa ,Sina Fellermeier-Kopf ,Saskia M Burm ,Kristin Strumane ,Aras Toker ,Andrea Imle ,Bruna de Andrade Pereira ,Alexander Muik ,Tahamtan Ahmadi ,Özlem Türeci ,Mark Fereshteh ,Ugur Sahin ,Maria Jure-Kunkel ,Nora Pencheva

A hexamerization-enhanced, Fc-silenced agonistic CD27 antibody amplifies T-cell effector functions as single agent and in combination with PD-1 blockade

一种经六聚化增强、Fc沉默的激动性CD27抗体,可作为单药或与PD-1阻断剂联合使用,增强T细胞效应功能。

Işıl Altıntaş ,Kristina B Nürmberger ,Andrea Imle ,Anna-Lena Krause ,Marike M van Beuge ,Aras Toker ,Andreea Ioan-Facsinay ,Jordan Blum ,Alexander Muik ,Frank J Beurskens ,Rob N de Jong ,David P E Satijn ,Friederike Gieseke ,Bart-Jan de Kreuk ,Maarten van der Kroef ,Sina Fellermeier-Kopf ,Tahamtan Ahmadi ,Özlem Türeci ,Esther C W Breij ,Uğur Şahin

Integrative gene network and functional analyses identify a prognostically relevant key regulator of metastasis in Ewing sarcoma

整合基因网络和功能分析鉴定出尤文氏肉瘤转移的预后相关关键调控因子

Cidre-Aranaz, Florencia; Li, Jing; Hölting, Tilman L B; Orth, Martin F; Imle, Roland; Kutschmann, Stefanie; Ammirati, Giulia; Ceranski, Katharina; Carreño-Gonzalez, Martha Julia; Kasan, Merve; Marchetto, Aruna; Funk, Cornelius M; Bestvater, Felix; Bersini, Simone; Arrigoni, Chiara; Moretti, Matteo; Thiel, Uwe; Baumhoer, Daniel; Sahm, Felix; Pfister, Stefan M; Hartmann, Wolfgang; Dirksen, Uta; Romero-Pérez, Laura; Banito, Ana; Ohmura, Shunya; Musa, Julian; Kirchner, Thomas; Knott, Maximilian M L; Grünewald, Thomas G P

Functional Therapeutic Target Validation Using Pediatric Zebrafish Xenograft Models

使用儿童斑马鱼异种移植模型进行功能治疗靶点验证

Charlotte Gatzweiler, Johannes Ridinger, Sonja Herter, Xenia F Gerloff, Dina ElHarouni, Yannick Berker, Roland Imle, Lukas Schmitt, Sina Kreth, Sabine Stainczyk, Simay Ayhan, Sara Najafi, Damir Krunic, Karen Frese, Benjamin Meder, David Reuss, Petra Fiesel, Kathrin Schramm, Mirjam Blattner-Johnson,