日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

The interleukin-1α stimulated expression of the wrinkle-inducing elastase neprilysin in adult human dermal fibroblasts is mediated via the intracellular signaling axis of ERK/JNK/c-Jun/c-Fos/AP-1.

白细胞介素-1α刺激成人真皮成纤维细胞中皱纹诱导弹性蛋白酶脑啡肽酶的表达是通过ERK/JNK/c-Jun/c-Fos/AP-1的细胞内信号轴介导的

期刊:Journal of Dermatology
影响因子:2.7
doi:10.1111/1346-8138.17520
Takada Mariko, Pinnawala Uma Chandula, Hirano Shinichi, Imokawa Genji
信号转导
细胞生物学
MAPK/ERK
Human
JNK
发表日期：2025
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Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos

抗坏血酸葡糖苷-精氨酸复合物治疗可改善日光性雀斑

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms252413453
Takada, Mariko; Numano, Kayoko; Nakano, Masahiko; Yamamoto, Akio; Imokawa, Genji
发表日期：2024
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A Nano-Emulsion Containing Ceramide-like Lipo-Amino Acid Cholesteryl Derivatives Improves Skin Symptoms in Patients with Atopic Dermatitis by Ameliorating the Water-Holding Function

含有神经酰胺样脂氨基酸胆固醇衍生物的纳米乳液通过改善皮肤的保水功能，改善特应性皮炎患者的皮肤症状。

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms232113362
Takada, Mariko; Ishikawa, Yuko; Numano, Kayoko; Hirano, Shinichi; Imokawa, Genji
代谢
发表日期：2022
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The Attenuated Secretion of Hyaluronan by UVA-Exposed Human Fibroblasts Is Associated with Up- and Downregulation of HYBID and HAS2 Expression via Activated and Inactivated Signaling of the p38/ATF2 and JAK2/STAT3 Cascades

UVA照射导致人类成纤维细胞透明质酸分泌减少，这与p38/ATF2和JAK2/STAT3级联信号通路的激活和失活导致HYBID和HAS2表达上调和下调有关。

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms22042057
Terazawa, Shuko; Takada, Mariko; Sato, Yoriko; Nakajima, Hiroaki; Imokawa, Genji
成纤维细胞
JAK/STAT
信号转导
JAK2
STAT3
Human
细胞生物学
BID
ATF2
发表日期：2021
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Cutting Edge of the Pathogenesis of Atopic Dermatitis: Sphingomyelin Deacylase, the Enzyme Involved in Its Ceramide Deficiency, Plays a Pivotal Role

特应性皮炎发病机制研究前沿：鞘磷脂脱酰酶（一种参与神经酰胺缺乏的酶）发挥关键作用

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms22041613
Imokawa, Genji
发表日期：2021
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Sphingomyelin Deacylase, the Enzyme Involved in the Pathogenesis of Atopic Dermatitis, Is Identical to the β-Subunit of Acid Ceramidase

鞘磷脂脱酰酶是参与特应性皮炎发病机制的酶，它与酸性神经酰胺酶的β亚基相同。

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms21228789
Teranishi, Yasuhiro; Kuwahara, Hiroshi; Ueda, Masaru; Takemura, Tadashi; Kusumoto, Masanori; Nakamura, Keiji; Sakai, Jun; Kimura, Toru; Furutani, Yasuji; Kawashima, Makoto; Imokawa, Genji; Nogami-Itoh, Mari
发表日期：2020
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Mycosporine-like amino acids stimulate hyaluronan secretion by up-regulating hyaluronan synthase 2 via activation of the p38/MSK1/CREB/c-Fos/AP-1 axis

类菌孢素氨基酸通过激活p38/MSK1/CREB/c-Fos/AP-1轴，上调透明质酸合成酶2，从而刺激透明质酸分泌。

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.RA119.011139
Terazawa, Shuko; Nakano, Masahiko; Yamamoto, Akio; Imokawa, Genji
MSK1
CREB
c-Fos
多发性硬化症
发表日期：2020
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Melanocyte Activation Mechanisms and Rational Therapeutic Treatments of Solar Lentigos

日光性雀斑的黑素细胞活化机制及合理治疗方法

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms20153666
Imokawa, Genji
细胞生物学
发表日期：2019
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Biological mechanisms underlying the ultraviolet radiation-induced formation of skin wrinkling and sagging I: reduced skin elasticity, highly associated with enhanced dermal elastase activity, triggers wrinkling and sagging

紫外线辐射诱导皮肤皱纹和松弛形成的生物学机制 I：皮肤弹性降低（与真皮弹性蛋白酶活性增强密切相关）引发皱纹和松弛。

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms16047753
Imokawa, Genji; Ishida, Koichi
发表日期：2015
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Biological mechanisms underlying the ultraviolet radiation-induced formation of skin wrinkling and sagging II: over-expression of neprilysin plays an essential role

紫外线辐射诱导皮肤皱纹和松弛形成的生物学机制 II：脑啡肽酶过度表达起着至关重要的作用

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms16047776
Imokawa, Genji; Nakajima, Hiroaki; Ishida, Koichi
神经科学
发表日期：2015
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