日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular Phenotypes Segregate Missense Mutations in SLC13A5 Epilepsy

分子表型分离 SLC13A5 癫痫中的错义突变

Valeria Jaramillo-Martinez,Souad R Sennoune,Elena B Tikhonova,Andrey L Karamyshev,Vadivel Ganapathy,Ina L Urbatsch

Replacing the eleven native tryptophans by directed evolution produces an active P-glycoprotein with site-specific, non-conservative substitutions

通过定向进化取代 11 种天然色氨酸,产生具有位点特异性、非保守取代的活性 P-糖蛋白

Douglas J Swartz, Anukriti Singh, Narong Sok, Joshua N Thomas, Joachim Weber, Ina L Urbatsch

Interactions and cooperativity between P-glycoprotein structural domains determined by thermal unfolding provides insights into its solution structure and function

通过热展开确定的 P 糖蛋白结构域之间的相互作用和协同作用为其溶液结构和功能提供了见解

Zhengrong Yang, Qingxian Zhou, Leo Mok, Anukriti Singh, Douglas J Swartz, Ina L Urbatsch, Christie G Brouillette

Crystal structure of the human sterol transporter ABCG5/ABCG8

人类固醇转运体 ABCG5/ABCG8 的晶体结构

Jyh-Yeuan Lee, Lisa N Kinch, Dominika M Borek, Jin Wang, Junmei Wang, Ina L Urbatsch, Xiao-Song Xie, Nikolai V Grishin, Jonathan C Cohen, Zbyszek Otwinowski, Helen H Hobbs, Daniel M Rosenbaum

Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein

P-糖蛋白中配体进入、可塑性结合和诱导螺旋运动的快照

Paul Szewczyk, Houchao Tao, Aaron P McGrath, Mark Villaluz, Steven D Rees, Sung Chang Lee, Rupak Doshi, Ina L Urbatsch, Qinghai Zhang, Geoffrey Chang

P-glycoprotein is fully active after multiple tryptophan substitutions

P-糖蛋白经过多次色氨酸取代后完全活跃

Douglas J Swartz, Joachim Weber, Ina L Urbatsch

A gene optimization strategy that enhances production of fully functional P-glycoprotein in Pichia pastoris

增强毕赤酵母中全功能 P 糖蛋白产量的基因优化策略

Jiangping Bai, Douglas J Swartz, Irina I Protasevich, Christie G Brouillette, Patina M Harrell, Ellen Hildebrandt, Brigitte Gasser, Diethard Mattanovich, Andrew Ward, Geoffrey Chang, Ina L Urbatsch