日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Neuroblastoma response to RAS-MAPK inhibitors and APR-246 (eprenetapopt) co-treatment is dependent on SLC7A11

神经母细胞瘤对 RAS-MAPK 抑制剂和 APR-246 (eprenetapopt) 联合治疗的反应依赖于 SLC7A11

Vid Mlakar, Ina Oehme, Laurence Lesne, Sara Najafi, Marc Ansari, Fabienne Gumy-Pause

Combination drug screen identifies synergistic drug interaction of BCL-XL and class I histone deacetylase inhibitors in MYC-amplified medulloblastoma cells

联合药物筛选确定了 BCL-XL 与 I 类组蛋白去乙酰化酶抑制剂在 MYC 扩增的髓母细胞瘤细胞中的协同药物相互作用

Simon Zeuner, Johanna Vollmer, Romain Sigaud, Sina Oppermann, Heike Peterziel, Dina ElHarouni, Ina Oehme, Olaf Witt, Till Milde, Jonas Ecker

ERBB and P-glycoprotein inhibitors break resistance in relapsed neuroblastoma models through P-glycoprotein

ERBB 和 P-糖蛋白抑制剂通过 P-糖蛋白打破复发性神经母细胞瘤模型中的耐药性

Lisa Rösch, Sonja Herter, Sara Najafi, Johannes Ridinger, Heike Peterziel, Jindrich Cinatl, David T W Jones, Martin Michaelis, Olaf Witt, Ina Oehme

Generation of patient-derived pediatric pilocytic astrocytoma in-vitro models using SV40 large T: evaluation of a modeling workflow

使用 SV40 大 T 生成患者来源的儿童毛细胞星形细胞瘤体外模型:建模工作流程评估

Florian Selt, Ahmed El Damaty, Martin U Schuhmann, Romain Sigaud, Jonas Ecker, Philipp Sievers, Daniela Kocher, Christel Herold-Mende, Ina Oehme, Andreas von Deimling, Stefan M Pfister, Felix Sahm, David T W Jones, Olaf Witt, Till Milde

Class I HDAC inhibition reduces DNA damage repair capacity of MYC-amplified medulloblastoma cells

类 HDAC 抑制可降低 MYC 扩增的髓母细胞瘤细胞的 DNA 损伤修复能力

Johanna Vollmer #, Jonas Ecker #, Thomas Hielscher, Gintvile Valinciute, Johannes Ridinger, Nora Jamaladdin, Heike Peterziel, Cornelis M van Tilburg, Ina Oehme, Olaf Witt, Till Milde

Synthesis, Biochemical, and Cellular Evaluation of HDAC6 Targeting Proteolysis Targeting Chimeras

针对蛋白水解的HDAC6靶向嵌合体的合成、生化和细胞评估

Salma Darwish, Tino Heimburg, Johannes Ridinger, Daniel Herp, Matthias Schmidt, Christophe Romier, Manfred Jung, Ina Oehme, Wolfgang Sippl

Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells

鉴定调节转化细胞自噬的组蛋白去乙酰化酶 10 (HDAC10) 抑制剂

Patrik Zeyen, Yanira Zeyn, Daniel Herp, Fereshteh Mahmoudi, Talha Z Yesiloglu, Frank Erdmann, Matthias Schmidt, Dina Robaa, Christophe Romier, Johannes Ridinger, Corey J Herbst-Gervasoni, David W Christianson, Ina Oehme, Manfred Jung, Oliver H Krämer, Wolfgang Sippl

First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement

首次通过荧光乙酰亚精胺脱乙酰化试验鉴定出与细胞靶标结合的选择性抑制剂

Daniel Herp, Johannes Ridinger, Dina Robaa, Stephen A Shinsky, Karin Schmidtkunz, Talha Z Yesiloglu, Theresa Bayer, Raphael R Steimbach, Corey J Herbst-Gervasoni, Annika Merz, Christophe Romier, Peter Sehr, Nikolas Gunkel, Aubry K Miller, David W Christianson, Ina Oehme, Wolfgang Sippl, Manfred Jung

Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity

具有抗神经母细胞瘤活性的组蛋白去乙酰化酶 8 (HDAC8) 蛋白水解靶向嵌合体 (PROTAC) 的设计、合成和生物学表征

Salma Darwish, Ehab Ghazy, Tino Heimburg, Daniel Herp, Patrik Zeyen, Rabia Salem-Altintas, Johannes Ridinger, Dina Robaa, Karin Schmidtkunz, Frank Erdmann, Matthias Schmidt, Christophe Romier, Manfred Jung, Ina Oehme, Wolfgang Sippl

Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma

MYC 染色质结合减少是 MYC 扩增髓母细胞瘤中 HDAC 抑制的一个关键作用

Jonas Ecker, Venu Thatikonda, Gianluca Sigismondo, Florian Selt, Gintvile Valinciute, Ina Oehme, Carina Müller, Juliane L Buhl, Johannes Ridinger, Diren Usta, Nan Qin, Cornelis M van Tilburg, Christel Herold-Mende, Marc Remke, Felix Sahm, Frank Westermann, Marcel Kool, Robert J Wechsler-Reya, Lukas