日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Down-regulation of AKT proteins slows the growth of mutant-KRAS pancreatic tumors

AKT 蛋白的下调减缓了 KRAS 突变型胰腺肿瘤的生长

Chuankai Chen, Ya-Ping Jiang, Inchul You, Nathanael S Gray, Richard Z Lin

Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation

乳腺癌细胞的多组学分析揭示了应激 MAPK 对 AKT 降解的敏感性

Emily C Erickson, Inchul You, Grace Perry, Aurelien Dugourd, Katherine A Donovan, Claire Crafter, Jeffrey W Johannes, Stuart Williamson, Jennifer I Moss, Susana Ros, Robert E Ziegler, Simon T Barry, Eric S Fischer, Nathanael S Gray, Ralitsa R Madsen, Alex Toker

Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors

基于结构的 Y 型共价 TEAD 抑制剂设计

Wenchao Lu, Mengyang Fan, Wenzhi Ji, Jason Tse, Inchul You, Scott B Ficarro, Isidoro Tavares, Jianwei Che, Audrey Y Kim, Xijun Zhu, Andrew Boghossian, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Stephen M Hinshaw, Behnam Nabet, Steven M Corsello, Nicholas Kwiatkowski, Jarrod A Marto, Tinghu Zh

Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1

开发一种对 c-Jun N 端蛋白激酶 (JNK) 2/3 具有选择性而非 JNK1 的共价抑制剂

Wenchao Lu ,Yao Liu ,Yang Gao ,Qixiang Geng ,Deepak Gurbani ,Lianbo Li ,Scott B Ficarro ,Cynthia J Meyer ,Dhiraj Sinha ,Inchul You ,Jason Tse ,Zhixiang He ,Wenzhi Ji ,Jianwei Che ,Audrey Y Kim ,Tengteng Yu ,Kenneth Wen ,Kenneth C Anderson ,Jarrod A Marto ,Kenneth D Westover ,Tinghu Zhang ,Nathanael S Gray

Targeted kinase degradation via the KLHDC2 ubiquitin E3 ligase

通过 KLHDC2 泛素 E3 连接酶进行靶向激酶降解

Younghoon Kim, Pooreum Seo, Eunhye Jeon, Inchul You, Kyubin Hwang, Namkyoung Kim, Jason Tse, Juhyeon Bae, Ha-Soon Choi, Stephen M Hinshaw, Nathanael S Gray, Taebo Sim

Acute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation

ERK5的急性药理学降解不会抑制细胞免疫反应或增殖。

Inchul You ,Katherine A Donovan ,Noah M Krupnick ,Andrew S Boghossian ,Matthew G Rees ,Melissa M Ronan ,Jennifer A Roth ,Eric S Fischer ,Eric S Wang ,Nathanael S Gray

Exploring the target scope of KEAP1 E3 ligase-based PROTACs

探索基于 KEAP1 E3 连接酶的 PROTAC 的靶标范围

Guangyan Du, Jie Jiang, Nathaniel J Henning, Nozhat Safaee, Eriko Koide, Radosław P Nowak, Katherine A Donovan, Hojong Yoon, Inchul You, Hong Yue, Nicholas A Eleuteri, Zhixiang He, Zhengnian Li, Hubert T Huang, Jianwei Che, Behnam Nabet, Tinghu Zhang, Eric S Fischer, Nathanael S Gray

Discovery and resistance mechanism of a selective CDK12 degrader

选择性 CDK12 降解剂的发现及其抗性机制

Baishan Jiang #, Yang Gao #, Jianwei Che #, Wenchao Lu, Ines H Kaltheuner, Ruben Dries, Marian Kalocsay, Matthew J Berberich, Jie Jiang, Inchul You, Nicholas Kwiatkowski, Kristin M Riching, Danette L Daniels, Peter K Sorger, Matthias Geyer, Tinghu Zhang, Nathanael S Gray

Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development

绘制可降解激酶组图谱为加速降解剂开发提供资源

Katherine A Donovan, Fleur M Ferguson, Jonathan W Bushman, Nicholas A Eleuteri, Debabrata Bhunia, SeongShick Ryu, Li Tan, Kun Shi, Hong Yue, Xiaoxi Liu, Dennis Dobrovolsky, Baishan Jiang, Jinhua Wang, Mingfeng Hao, Inchul You, Mingxing Teng, Yanke Liang, John Hatcher, Zhengnian Li, Theresa D Manz, B

Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling

发现一种能长期抑制下游信号的 AKT 降解剂

Inchul You, Emily C Erickson, Katherine A Donovan, Nicholas A Eleuteri, Eric S Fischer, Nathanael S Gray, Alex Toker