日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of a conserved subset of cold tumors responsive to immune checkpoint blockade

鉴定对免疫检查点阻断疗法有反应的保守冷肿瘤亚群

Jade Moore ,Jim Gkantalis ,Ines Guix ,William Chou ,Kobe Yuen ,Ann A Lazar ,Matthew Spitzer ,Alexis Combes ,Mary Helen Barcellos-Hoff

Lack of TGFβ signaling competency predicts immune poor cancer conversion to immune rich and response to checkpoint blockade

TGFβ 信号传导能力缺乏可预测免疫功能低下的癌症将转变为免疫功能丰富的癌症并对检查点阻断作出反应

Jade Moore, Jim Gkantalis, Ines Guix, William Chou, Kobe Yuen, Ann A Lazar, Mathew Spitzer, Alexis J Combes, Mary Helen Barcellos-Hoff

Validation of Anticorrelated TGFβ Signaling and Alternative End-Joining DNA Repair Signatures that Predict Response to Genotoxic Cancer Therapy

验证反相关的TGFβ信号传导和替代性末端连接DNA修复特征,以预测对基因毒性癌症疗法的反应

Ines Guix ,Qi Liu ,Miquel Angel Pujana ,Patrick Ha ,Josep Piulats ,Isabel Linares ,Ferran Guedea ,Jian-Hua Mao ,Ann Lazar ,Jocelyn Chapman ,Sue S Yom ,Alan Ashworth ,Mary Helen Barcellos-Hoff

Loss of TGFβ signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types

TGFβ 信号的丧失会增加替代性末端连接 DNA 修复,从而增强癌症类型对基因毒性疗法的敏感性

Qi Liu, Luis Palomero, Jade Moore, Ines Guix, Roderic Espín, Alvaro Aytés, Jian-Hua Mao, Amanda G Paulovich, Jeffrey R Whiteaker, Richard G Ivey, George Iliakis, Daxian Luo, Anthony J Chalmers, John Murnane, Miquel Angel Pujana, Mary Helen Barcellos-Hoff