日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting specific kinase substrates rescues increased colitis severity induced by the Crohn's disease-linked LRRK2-N2081D variant

靶向特定激酶底物可缓解由克罗恩病相关LRRK2-N2081D变异体引起的结肠炎病情加重。

George R Heaton ,Xingjian Li ,Xianting Li ,Xiaoting Zhou ,Yuanxi Zhang ,Duc Tung Vu ,Marc Oeller ,Ozge Karayel ,Quyen Q Hoang ,Meltem Ece Kars ,Nitika Kamath ,Minghui Wang ,Leonid Tarassishin ,Matthias Mann ,Inga Peter ,Zhenyu Yue

Macrophage LRRK2 hyperactivity impairs autophagy and induces Paneth cell dysfunction

巨噬细胞LRRK2过度激活会损害自噬并诱导潘氏细胞功能障碍。

Shengxiang Sun ,Miki Hodel ,Xiang Wang ,Javier De Vicente ,Talin Haritunians ,Anketse Debebe ,Chen-Ting Hung ,Changqing Ma ,Atika Malique ,Hoang N Nguyen ,Maayan Agam ,Michael T Maloney ,Marisa S Goo ,Jillian H Kluss ,Richa Mishra ,Jennifer Frein ,Amanda Foster ,Samuel Ballentine ,Uday Pandey ,Justin Kern ,Shaohong Yang ,Emebet Mengesha ,Iyshwarya Balasubramanian ,Annie Arguello ,Anthony A Estrada ,Nan Gao ,Inga Peter ,Dermot P B McGovern ,Anastasia G Henry ,Thaddeus S Stappenbeck ,Ta-Chiang Liu

Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14th century

来自中世纪德国犹太人的全基因组数据显示,阿什肯纳兹犹太人的起源事件早于14世纪。

Shamam Waldman ,Daniel Backenroth ,Éadaoin Harney ,Stefan Flohr ,Nadia C Neff ,Gina M Buckley ,Hila Fridman ,Ali Akbari ,Nadin Rohland ,Swapan Mallick ,Iñigo Olalde ,Leo Cooper ,Ariel Lomes ,Joshua Lipson ,Jorge Cano Nistal ,Jin Yu ,Nir Barzilai ,Inga Peter ,Gil Atzmon ,Harry Ostrer ,Todd Lencz ,Yosef E Maruvka ,Maike Lämmerhirt ,Alexander Beider ,Leonard V Rutgers ,Virginie Renson ,Keith M Prufer ,Stephan Schiffels ,Harald Ringbauer ,Karin Sczech ,Shai Carmi ,David Reich

17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson's disease are associated with LRRC37A/2 expression in astrocytes

17q21.31 亚单倍型与 H1 相关的帕金森病风险有关,这些亚单倍型与星形胶质细胞中的 LRRC37A/2 表达有关

Kathryn R Bowles, Derian A Pugh, Yiyuan Liu, Tulsi Patel, Alan E Renton, Sara Bandres-Ciga, Ziv Gan-Or, Peter Heutink, Ari Siitonen, Sarah Bertelsen, Jonathan D Cherry, Celeste M Karch, Steven J Frucht, Brian H Kopell, Inga Peter, Y J Park; International Parkinson’s Disease Genomics Consortium (IPDG

Inflamed Ulcerative Colitis Regions Associated With MRGPRX2-Mediated Mast Cell Degranulation and Cell Activation Modules, Defining a New Therapeutic Target

与MRGPRX2介导的肥大细胞脱颗粒和细胞活化模块相关的炎症性溃疡性结肠炎区域,定义了一个新的治疗靶点

Ernie Chen ,Ling-Shiang Chuang ,Mamta Giri ,Nicole Villaverde ,Nai-Yun Hsu ,Ksenija Sabic ,Sari Joshowitz ,Kyle Gettler ,Shikha Nayar ,Zhi Chai ,Isaac L Alter ,Colleen C Chasteau ,Ujunwa M Korie ,Siarhei Dzedzik ,Tin Htwe Thin ,Aayushee Jain ,Arden Moscati ,Gerardus Bongers ,Richard H Duerr ,Mark S Silverberg ,Steven R Brant ,John D Rioux ,Inga Peter ,L Philip Schumm ,Talin Haritunians ,Dermot P McGovern ,Yuval Itan ,Judy H Cho

Gut microbiota density influences host physiology and is shaped by host and microbial factors

肠道菌群密度影响宿主生理,并受宿主和微生物因素的影响。

Eduardo J Contijoch ,Graham J Britton ,Chao Yang ,Ilaria Mogno ,Zhihua Li ,Ruby Ng ,Sean R Llewellyn ,Sheela Hira ,Crystal Johnson ,Keren M Rabinowitz ,Revital Barkan ,Iris Dotan ,Robert P Hirten ,Shih-Chen Fu ,Yuying Luo ,Nancy Yang ,Tramy Luong ,Philippe R Labrias ,Sergio Lira ,Inga Peter ,Ari Grinspan ,Jose C Clemente ,Roman Kosoy ,Seunghee Kim-Schulze ,Xiaochen Qin ,Anabella Castillo ,Amanda Hurley ,Ashish Atreja ,Jason Rogers ,Farah Fasihuddin ,Merjona Saliaj ,Amy Nolan ,Pamela Reyes-Mercedes ,Carina Rodriguez ,Sarah Aly ,Kenneth Santa-Cruz ,Lauren Peters ,Mayte Suárez-Fariñas ,Ruiqi Huang ,Ke Hao ,Jun Zhu ,Bin Zhang ,Bojan Losic ,Haritz Irizar ,Won-Min Song ,Antonio Di Narzo ,Wenhui Wang ,Benjamin L Cohen ,Christopher DiMaio ,David Greenwald ,Steven Itzkowitz ,Aimee Lucas ,James Marion ,Elana Maser ,Ryan Ungaro ,Steven Naymagon ,Joshua Novak ,Brijen Shah ,Thomas Ullman ,Peter Rubin ,James George ,Peter Legnani ,Shannon E Telesco ,Joshua R Friedman ,Carrie Brodmerkel ,Scott Plevy ,Judy H Cho ,Jean-Frederic Colombel ,Eric E Schadt ,Carmen Argmann ,Marla Dubinsky ,Andrew Kasarskis ,Bruce Sands ,Jeremiah J Faith

An increase in LRRK2 suppresses autophagy and enhances Dectin-1-induced immunity in a mouse model of colitis

在小鼠结肠炎模型中,LRRK2 的增加可抑制自噬并增强 Dectin-1 诱导的免疫力

Tetsuya Takagawa, Atsushi Kitani, Ivan Fuss, Beth Levine, Steven R Brant, Inga Peter, Masaki Tajima, Shiro Nakamura, Warren Strober

Quantitative and multiplexed DNA methylation analysis using long-read single-molecule real-time bisulfite sequencing (SMRT-BS)

利用长读长单分子实时亚硫酸氢盐测序(SMRT-BS)进行定量和多重DNA甲基化分析

Yao Yang,Robert Sebra,Benjamin S Pullman,Wanqiong Qiao,Inga Peter,Robert J Desnick,C Ronald Geyer,John F DeCoteau,Stuart A Scott

The UDP-glucuronosyltransferase (UGT) 1A polymorphism c.2042C>G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-induced acute liver failure

UDP-葡萄糖醛酸转移酶 (UGT) 1A 多态性 c.2042C>G (rs8330) 与人类肝脏对乙酰氨基酚葡萄糖醛酸化增加、UGT1A 外显子 5a/5b 剪接变体 mRNA 比率增加以及意外对乙酰氨基酚诱发的急性肝衰竭风险降低有关

Michael H Court, Marina Freytsis, Xueding Wang, Inga Peter, Chantal Guillemette, Suwagmani Hazarika, Su X Duan, David J Greenblatt, William M Lee; Acute Liver Failure Study Group

Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2(+P253R) mice

Apert 综合征 Fgfr2(+P253R) 小鼠颅骨异常中 p38 MAPK 通路的激活

Yingli Wang, Miao Sun, Victoria L Uhlhorn, Xueyan Zhou, Inga Peter, Neus Martinez-Abadias, Cheryl A Hill, Christopher J Percival, Joan T Richtsmeier, David L Huso, Ethylin Wang Jabs