日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

出版商更正:DHODH抑制剂通过阻断p53降解来增加p53合成并增强肿瘤细胞杀伤作用。

Ladds, Marcus J G W; van Leeuwen, Ingeborg M M; Drummond, Catherine J; Chu, Su; Healy, Alan R; Popova, Gergana; Fernández, Andrés Pastor; Mollick, Tanzina; Darekar, Suhas; Sedimbi, Saikiran K; Nekulova, Marta; Sachweh, Marijke C C; Campbell, Johanna; Higgins, Maureen; Tuck, Chloe; Popa, Mihaela; Safont, Mireia Mayoral; Gelebart, Pascal; Fandalyuk, Zinayida; Thompson, Alastair M; Svensson, Richard; Gustavsson, Anna-Lena; Johansson, Lars; Färnegårdh, Katarina; Yngve, Ulrika; Saleh, Aljona; Haraldsson, Martin; D'Hollander, Agathe C A; Franco, Marcela; Zhao, Yan; Håkansson, Maria; Walse, Björn; Larsson, Karin; Peat, Emma M; Pelechano, Vicent; Lunec, John; Vojtesek, Borivoj; Carmena, Mar; Earnshaw, William C; McCarthy, Anna R; Westwood, Nicholas J; Arsenian-Henriksson, Marie; Lane, David P; Bhatia, Ravi; McCormack, Emmet; Laín, Sonia

Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology

利用二氢乳清酸脱氢酶 (DHODH) 和 p53 激活作为治疗靶点:多药理学案例研究

Marcus J G W Ladds ,Gergana Popova ,Andrés Pastor-Fernández ,Srinivasaraghavan Kannan ,Ingeborg M M van Leeuwen ,Maria Håkansson ,Björn Walse ,Fredrik Tholander ,Ravi Bhatia ,Chandra S Verma ,David P Lane ,Sonia Laín

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

出版商更正:DHODH抑制剂通过阻断p53降解来增加p53合成并增强肿瘤细胞杀伤作用。

Ladds, Marcus J G W; van Leeuwen, Ingeborg M M; Drummond, Catherine J; Chu, Su; Healy, Alan R; Popova, Gergana; Pastor Fernández, Andrés; Mollick, Tanzina; Darekar, Suhas; Sedimbi, Saikiran K; Nekulova, Marta; Sachweh, Marijke C C; Campbell, Johanna; Higgins, Maureen; Tuck, Chloe; Popa, Mihaela; Safont, Mireia Mayoral; Gelebart, Pascal; Fandalyuk, Zinayida; Thompson, Alastair M; Svensson, Richard; Gustavsson, Anna-Lena; Johansson, Lars; Färnegårdh, Katarina; Yngve, Ulrika; Saleh, Aljona; Haraldsson, Martin; D'Hollander, Agathe C A; Franco, Marcela; Zhao, Yan; Håkansson, Maria; Walse, Björn; Larsson, Karin; Peat, Emma M; Pelechano, Vicent; Lunec, John; Vojtesek, Borivoj; Carmena, Mar; Earnshaw, William C; McCarthy, Anna R; Westwood, Nicholas J; Arsenian-Henriksson, Marie; Lane, David P; Bhatia, Ravi; McCormack, Emmet; Laín, Sonia

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

DHODH抑制剂通过阻断p53降解,增加p53的合成并增强对肿瘤细胞的杀伤作用。

Marcus J G W Ladds ,Ingeborg M M van Leeuwen ,Catherine J Drummond ,Su Chu ,Alan R Healy ,Gergana Popova ,Andrés Pastor Fernández ,Tanzina Mollick ,Suhas Darekar ,Saikiran K Sedimbi ,Marta Nekulova ,Marijke C C Sachweh ,Johanna Campbell ,Maureen Higgins ,Chloe Tuck ,Mihaela Popa ,Mireia Mayoral Safont ,Pascal Gelebart ,Zinayida Fandalyuk ,Alastair M Thompson ,Richard Svensson ,Anna-Lena Gustavsson ,Lars Johansson ,Katarina Färnegårdh ,Ulrika Yngve ,Aljona Saleh ,Martin Haraldsson ,Agathe C A D'Hollander ,Marcela Franco ,Yan Zhao ,Maria Håkansson ,Björn Walse ,Karin Larsson ,Emma M Peat ,Vicent Pelechano ,John Lunec ,Borivoj Vojtesek ,Mar Carmena ,William C Earnshaw ,Anna R McCarthy ,Nicholas J Westwood ,Marie Arsenian-Henriksson ,David P Lane ,Ravi Bhatia ,Emmet McCormack ,Sonia Laín

Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase

脂质塑造外周膜蛋白二氢乳清酸脱氢酶的电子受体结合位点

Joana Costeira-Paulo ,Joseph Gault ,Gergana Popova ,Marcus J G W Ladds ,Ingeborg M M van Leeuwen ,Médoune Sarr ,Anders Olsson ,David P Lane ,Sonia Laín ,Erik G Marklund ,Michael Landreh

Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib

弱碱性替诺文的积累导致自噬通量阻断,进而清除在维莫非尼治疗后存活的B-Raf突变肿瘤细胞。

Marcus J G W Ladds ,Andrés Pastor-Fernández ,Gergana Popova ,Ingeborg M M van Leeuwen ,Kai Er Eng ,Catherine J Drummond ,Lars Johansson ,Richard Svensson ,Nicholas J Westwood ,Anna R McCarthy ,Fredrik Tholander ,Mihaela Popa ,David P Lane ,Emmet McCormack ,Gerald M McInerney ,Ravi Bhatia ,Sonia Laín

Modulation of p53 C-terminal acetylation by mdm2, p14ARF, and cytoplasmic SirT2

mdm2、p14ARF 和细胞质 SirT2 对 p53 C 末端乙酰化的调节

Ingeborg M M van Leeuwen, Maureen Higgins, Johanna Campbell, Anna R McCarthy, Marijke C C Sachweh, Ana Marín Navarro, Sonia Laín

An evaluation of small-molecule p53 activators as chemoprotectants ameliorating adverse effects of anticancer drugs in normal cells.

对小分子 p53 激活剂作为化学保护剂,减轻抗癌药物对正常细胞的不良反应的评价

van Leeuwen Ingeborg M M, Rao Bhavya, Sachweh Marijke C C, Laín Sonia

Cyclotherapy: opening a therapeutic window in cancer treatment

旋切疗法:为癌症治疗打开一扇新的治疗窗口

van Leeuwen, Ingeborg M M

Pharmacological manipulation of the cell cycle and metabolism to protect normal tissues against conventional anticancer drugs

通过药物手段调控细胞周期和代谢,以保护正常组织免受传统抗癌药物的侵害

van Leeuwen, Ingeborg M M; Laín, Sonia