日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes

线粒体呼吸体水平大幅降低的小鼠的呼吸链能力和生理机能得以保留

Dusanka Milenkovic, Jelena Misic, Johannes F Hevler, Thibaut Molinié, Injae Chung, Ilian Atanassov, Xinping Li, Roberta Filograna, Andrea Mesaros, Arnaud Mourier, Albert J R Heck, Judy Hirst, Nils-Göran Larsson

Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster

果蝇线粒体呼吸复合物 I 的低温电子显微镜结构

Ahmed-Noor A Agip #, Injae Chung #, Alvaro Sanchez-Martinez #, Alexander J Whitworth, Judy Hirst

The antipsychotic medications aripiprazole, brexpiprazole and cariprazine are off-target respiratory chain complex I inhibitors

抗精神病药物阿立哌唑、布瑞哌唑和卡利拉嗪是脱靶呼吸链复合物 I 抑制剂

Rachel E Hardy, Injae Chung, Yizhou Yu, Samantha H Y Loh, Nobuhiro Morone, Clement Soleilhavoup, Marco Travaglio, Riccardo Serreli, Lia Panman, Kelvin Cain, Judy Hirst, Luis M Martins, Marion MacFarlane, Kenneth R Pryde

Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy

低温电子显微镜结构定义泛醌-10 与线粒体复合物 I 的结合以及伴随 Q 位点占据的构象转变

Injae Chung, John J Wright #, Hannah R Bridges #, Bozhidar S Ivanov #, Olivier Biner, Caroline S Pereira, Guilherme M Arantes, Judy Hirst

Cork-in-bottle mechanism of inhibitor binding to mammalian complex I

抑制剂与哺乳动物复合物 I 结合的“瓶塞式”机制

Injae Chung, Riccardo Serreli, Jason B Cross, M Emilia Di Francesco, Joseph R Marszalek, Judy Hirst

Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I

鉴定抗癌化疗药物中针对线粒体呼吸复合物 I 的新型毒理团

Zoe A Stephenson, Robert F Harvey #, Kenneth R Pryde #, Sarah Mistry, Rachel E Hardy, Riccardo Serreli, Injae Chung, Timothy Eh Allen, Mark Stoneley, Marion MacFarlane, Peter M Fischer, Judy Hirst, Barrie Kellam, Anne E Willis

Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites

新型 Chk1 抑制剂 SCH900776 与 DNA 损伤剂和抗代谢药联合使用的临床前开发

Ryan Montano, Injae Chung, Kristen M Garner, David Parry, Alan Eastman