日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Two randomised controlled phase 2 studies of the oral neutrophil elastase inhibitor alvelestat in alpha-1 antitrypsin deficiency

两项随机对照 II 期研究评估了口服中性粒细胞弹性蛋白酶抑制剂阿维司他治疗 α1-抗胰蛋白酶缺乏症的疗效

Wells, J Michael; Titlestad, Ingrid L; Tanash, Hanan; Turner, Alice M; Chapman, Kenneth R; Hatipoğlu, Umur Ş; Goldklang, Monica P; D'Armiento, Jeanine M; Pirozzi, Cheryl S; Drummond, M Bradley; Barjaktarevic, Igor Z; Chatila, Wissam M; Devine, Megan S; Strange, Charlie; Sandhaus, Robert A; Parkin, Jacqueline M; Westfall, Elizabeth; Lin, Vivian Y; Parks, Robin; Kuo, Hui-Chien; Ekue, Adzoa; Moffitt, Kelly L; Inshaw, Jamie; Aban, Inmaculada; Dransfield, Mark T; Stockley, Robert A

Bayesian Effect Size Ranking to Prioritise Genetic Risk Variants in Common Diseases for Follow-Up Studies.

贝叶斯效应大小排序用于确定常见疾病中遗传风险变异的优先顺序,以便进行后续研究

Crouch Daniel J M, Inshaw Jamie R J, Robertson Catherine C, Ng Esther, Zhang Jia-Yuan, Chen Wei-Min, Onengut-Gumuscu Suna, Cutler Antony J, Sidore Carlo, Cucca Francesco, Pociot Flemming, Concannon Patrick, Rich Stephen S, Todd John A

Anti-inflammatory therapy with nebulized dornase alfa for severe COVID-19 pneumonia: a randomized unblinded trial

雾化吸入阿法多诺酶治疗重症新冠肺炎的抗炎治疗:一项随机非盲试验

Joanna C Porter, Jamie Inshaw, Vincente Joel Solis, Emma Denneny, Rebecca Evans, Mia I Temkin #, Nathalia De Vasconcelos #, Iker Valle Aramburu #, Dennis Hoving #, Donna Basire, Tracey Crissell, Jesusa Guinto, Alison Webb, Hanif Esmail, Victoria Johnston, Anna Last, Thomas Rampling, Lena Lippert, El

Phase 2 Dose-Finding Study in Patients with Gout Using SEL-212, a Novel PEGylated Uricase (SEL-037) Combined with Tolerogenic Nanoparticles (SEL-110)

使用新型聚乙二醇化尿酸酶 (SEL-037) 与耐受性纳米颗粒 (SEL-110) 联合治疗痛风患者的 SEL-212 的 2 期剂量探索研究

Kivitz, Alan; DeHaan, Wesley; Azeem, Rehan; Park, Justin; Rhodes, Sheri; Inshaw, Jamie; Leung, Sheldon S; Nicolaou, Savvas; Johnston, Lloyd; Kishimoto, Takashi K; Traber, Peter G; Sands, Earl; Choi, Hyon

Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach

基于生命历程孟德尔随机化方法,儿童时期的体型直接增加1型糖尿病的风险。

Richardson, Tom G; Crouch, Daniel J M; Power, Grace M; Morales-Berstein, Fernanda; Hazelwood, Emma; Fang, Si; Cho, Yoonsu; Inshaw, Jamie R J; Robertson, Catherine C; Sidore, Carlo; Cucca, Francesco; Rich, Steven S; Todd, John A; Davey Smith, George

Circulating C-Peptide Levels in Living Children and Young People and Pancreatic β-Cell Loss in Pancreas Donors Across Type 1 Diabetes Disease Duration

型糖尿病病程中,活体儿童和青少年体内循环 C 肽水平与胰腺捐献者胰腺 β 细胞丢失的关系

Carr, Alice L J; Inshaw, Jamie R J; Flaxman, Christine S; Leete, Pia; Wyatt, Rebecca C; Russell, Lydia A; Palmer, Matthew; Prasolov, Dmytro; Worthington, Thomas; Hull, Bethany; Wicker, Linda S; Dunger, David B; Oram, Richard A; Morgan, Noel G; Todd, John A; Richardson, Sarah J; Besser, Rachel E J

Thymocyte regulatory variant alters transcription factor binding and protects from type 1 diabetes in infants

胸腺细胞调节变异体改变转录因子结合,并保护婴儿免受1型糖尿病的侵害

Sandholm, Niina; Rubio García, Arcadio; Pekalski, Marcin L; Inshaw, Jamie R J; Cutler, Antony J; Todd, John A

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes

精细定位、跨祖先和基因组分析可确定 1 型糖尿病的致病变异、细胞、基因和药物靶点

Catherine C Robertson #, Jamie R J Inshaw #, Suna Onengut-Gumuscu, Wei-Min Chen, David Flores Santa Cruz, Hanzhi Yang, Antony J Cutler, Daniel J M Crouch, Emily Farber, S Louis Bridges Jr, Jeffrey C Edberg, Robert P Kimberly, Jane H Buckner, Panos Deloukas, Jasmin Divers, Dana Dabelea, Jean M Lawren

Analysis of overlapping genetic association in type 1 and type 2 diabetes

1型和2型糖尿病重叠遗传关联的分析

Inshaw, Jamie R J; Sidore, Carlo; Cucca, Francesco; Stefana, M Irina; Crouch, Daniel J M; McCarthy, Mark I; Mahajan, Anubha; Todd, John A

PRF1 mutation alters immune system activation, inflammation, and risk of autoimmunity

PRF1基因突变会改变免疫系统激活、炎症反应和自身免疫性疾病的风险。

Sidore, Carlo; Orrù, Valeria; Cocco, Eleonora; Steri, Maristella; Inshaw, Jamie Rj; Pitzalis, Maristella; Mulas, Antonella; McGurnaghan, Stuart; Frau, Jessica; Porcu, Eleonora; Busonero, Fabio; Dei, Mariano; Lai, Sandra; Sole, Gabriella; Virdis, Francesca; Serra, Valentina; Poddie, Fausto; Delitala, Alessandro; Marongiu, Michele; Deidda, Francesca; Pala, Mauro; Floris, Matteo; Masala, Marco; Onengut-Gumuscu, Suna; Robertson, Catherine C; Leoni, Lidia; Frongia, Annapaola; Ricciardi, Maria Rossella; Chessa, Margherita; Olla, Nazario; Lovicu, Mario; Loizedda, Annalisa; Maschio, Andrea; Mereu, Luisa; Ferrigno, Paola; Curreli, Nicolo; Balaci, Lenuta; Loi, Francesco; Ferreli, Liana Ap; Pilia, Maria Grazia; Pani, Antonello; Marrosu, Maria Giovanna; Abecasis, Goncalo R; Rich, Stephen S; Colhoun, Helen; Todd, John A; Schlessinger, David; Fiorillo, Edoardo; Cucca, Francesco; Zoledziewska, Magdalena