日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Engineered immunological niche directs therapeutic development in models of progressive multiple sclerosis.

工程化免疫微环境指导进行性多发性硬化症模型中的治疗开发

Rad Laila M, Hughes Kevin R, Wheeler Sydney N, Decker Joseph T, Orbach Sophia M, Galvan Angelica, Thornhill Jasmine, Griffin Kate V, Turkistani Hamza, Urie Russell R, Irani David N, Shea Lonnie D, Morris Aaron H

Progressive multifocal leukoencephalopathy selectively affecting Broca's and Wernicke's areas in an immunocompetent patient: A case report

免疫功能正常患者选择性累及布罗卡区和韦尼克区的进行性多灶性白质脑病:病例报告

Kim, Renaid B; Irani, David N; Kim, John

Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis

利用工程化免疫微环境监测复发型多发性硬化症的疾病活动和治疗效果

Morris, Aaron H; Hughes, Kevin R; Oakes, Robert S; Cai, Michelle M; Miller, Stephen D; Irani, David N; Shea, Lonnie D

Type-1 angiotensin receptor signaling in central nervous system myeloid cells is pathogenic during fatal alphavirus encephalitis in mice

在小鼠致命性甲病毒脑炎中,中枢神经系统髓系细胞中的1型血管紧张素受体信号传导具有致病性。

Blakely, Pennelope K; Huber, Amanda K; Irani, David N

Regulated Production of CXCL13 within the Central Nervous System

中枢神经系统内CXCL13的调控性产生

Irani, David N

Astrocyte matricellular proteins that control excitatory synaptogenesis are regulated by inflammatory cytokines and correlate with paralysis severity during experimental autoimmune encephalomyelitis

控制兴奋性突触生成的星形胶质细胞基质蛋白受炎症细胞因子调控,并与实验性自身免疫性脑脊髓炎期间的瘫痪严重程度相关。

Blakely, Pennelope K; Hussain, Shabbir; Carlin, Lindsey E; Irani, David N

Manipulation of host factors optimizes the pathogenesis of western equine encephalitis virus infections in mice for antiviral drug development

通过调控宿主因子优化小鼠西部马脑炎病毒感染的致病机制,可用于抗病毒药物的研发。

Blakely, Pennelope K; Delekta, Phillip C; Miller, David J; Irani, David N

Optimization of novel indole-2-carboxamide inhibitors of neurotropic alphavirus replication

优化新型吲哚-2-甲酰胺类神经嗜性甲病毒复制抑制剂

Sindac, Janice A; Barraza, Scott J; Dobry, Craig J; Xiang, Jianming; Blakely, Pennelope K; Irani, David N; Keep, Richard F; Miller, David J; Larsen, Scott D

Discovery of potent broad spectrum antivirals derived from marine actinobacteria

从海洋放线菌中发现强效广谱抗病毒药物

Raveh, Avi; Delekta, Phillip C; Dobry, Craig J; Peng, Weiping; Schultz, Pamela J; Blakely, Pennelope K; Tai, Andrew W; Matainaho, Teatulohi; Irani, David N; Sherman, David H; Miller, David J

Novel inhibitors of neurotropic alphavirus replication that improve host survival in a mouse model of acute viral encephalitis

新型神经嗜性甲病毒复制抑制剂可提高急性病毒性脑炎小鼠模型中的宿主存活率

Sindac, Janice A; Yestrepsky, Bryan D; Barraza, Scott J; Bolduc, Kyle L; Blakely, Pennelope K; Keep, Richard F; Irani, David N; Miller, David J; Larsen, Scott D