日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Imbalanced TGFβ signalling and autophagy drive erythroid priming of hematopoietic stem cells in β-thalassemia

β-地中海贫血中TGFβ信号传导和自噬失衡驱动造血干细胞向红系分化。

Maria Rosa Lidonnici ,Giulia Chianella ,Nicole Mende ,Hugo P Bastos ,Matteo Barcella ,Ivan Merelli ,Mariangela Storto ,Valentina Romeo ,Francesca Tiboni ,Samantha Scaramuzza ,Claudia Rossi ,Laura Raggi ,Annamaria Aprile ,Stefania Crippa ,Deena Iskander ,Irene Roberts ,Anastasios Karamiditris ,Julia Keith ,Christophe Lechauve ,Mitchell J Weiss ,Nicola K Wilson ,Berthold Göttgens ,Maria Ester Bernardo ,Fabio Ciceri ,Alessandro Aiuti ,Sarah Marktel ,Elisa Laurenti ,Giuliana Ferrari

Yolk sac cell atlas reveals multiorgan functions during human early development

卵黄囊细胞图谱揭示了人类早期发育过程中的多器官功能

Issac Goh # ,Rachel A Botting # ,Antony Rose # ,Simone Webb # ,Justin Engelbert ,Yorick Gitton ,Emily Stephenson ,Mariana Quiroga Londoño ,Michael Mather ,Nicole Mende ,Ivan Imaz-Rosshandler ,Lu Yang ,Dave Horsfall ,Daniela Basurto-Lozada ,Nana-Jane Chipampe ,Victoria Rook ,Jimmy Tsz Hang Lee ,Mai-Linh Ton ,Daniel Keitley ,Pavel Mazin ,M S Vijayabaskar ,Rebecca Hannah ,Laure Gambardella ,Kile Green ,Stephane Ballereau ,Megumi Inoue ,Elizabeth Tuck ,Valentina Lorenzi ,Kwasi Kwakwa ,Clara Alsinet ,Bayanne Olabi ,Mohi Miah ,Chloe Admane ,Dorin-Mirel Popescu ,Meghan Acres ,David Dixon ,Thomas Ness ,Rowen Coulthard ,Steven Lisgo ,Deborah J Henderson ,Emma Dann ,Chenqu Suo ,Sarah J Kinston ,Jong-Eun Park ,Krzysztof Polanski ,John Marioni ,Stijn van Dongen ,Kerstin B Meyer ,Marella de Bruijn ,James Palis ,Sam Behjati ,Elisa Laurenti ,Nicola K Wilson ,Roser Vento-Tormo ,Alain Chédotal ,Omer Bayraktar ,Irene Roberts ,Laura Jardine ,Berthold Göttgens ,Sarah A Teichmann ,Muzlifah Haniffa

The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma

先天传感器 ZBP1-IRF3 轴调节多发性骨髓瘤中的细胞增殖

Kanagaraju Ponnusamy, Maria Myrsini Tzioni, Murshida Begum, Mark E Robinson, Valentina S Caputo, Alexia Katsarou, Nikolaos Trasanidis, Xiaolin Xiao, Ioannis V Kostopoulos, Deena Iskander, Irene Roberts, Pritesh Trivedi, Holger W Auner, Kikkeri Naresh, Aristeidis Chaidos, Anastasios Karadimitris

Blood and immune development in human fetal bone marrow and Down syndrome

人类胎儿骨髓中的血液和免疫发育与唐氏综合征

Laura Jardine # ,Simone Webb # ,Issac Goh ,Mariana Quiroga Londoño ,Gary Reynolds ,Michael Mather ,Bayanne Olabi ,Emily Stephenson ,Rachel A Botting ,Dave Horsfall ,Justin Engelbert ,Daniel Maunder ,Nicole Mende ,Caitlin Murnane ,Emma Dann ,Jim McGrath ,Hamish King ,Iwo Kucinski ,Rachel Queen ,Christopher D Carey ,Caroline Shrubsole ,Elizabeth Poyner ,Meghan Acres ,Claire Jones ,Thomas Ness ,Rowen Coulthard ,Natalina Elliott ,Sorcha O'Byrne ,Myriam L R Haltalli ,John E Lawrence ,Steven Lisgo ,Petra Balogh ,Kerstin B Meyer ,Elena Prigmore ,Kirsty Ambridge ,Mika Sarkin Jain ,Mirjana Efremova ,Keir Pickard ,Thomas Creasey ,Jaume Bacardit ,Deborah Henderson ,Jonathan Coxhead ,Andrew Filby ,Rafiqul Hussain ,David Dixon ,David McDonald ,Dorin-Mirel Popescu ,Monika S Kowalczyk ,Bo Li ,Orr Ashenberg ,Marcin Tabaka ,Danielle Dionne ,Timothy L Tickle ,Michal Slyper ,Orit Rozenblatt-Rosen ,Aviv Regev ,Sam Behjati ,Elisa Laurenti ,Nicola K Wilson ,Anindita Roy ,Berthold Göttgens ,Irene Roberts ,Sarah A Teichmann ,Muzlifah Haniffa

A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program

人类胎儿肝源性婴儿 MLL-AF4 急性淋巴细胞白血病模型揭示了独特的胎儿基因表达程序

Siobhan Rice, Thomas Jackson, Nicholas T Crump, Nicholas Fordham, Natalina Elliott, Sorcha O'Byrne, Maria Del Mar Lara Fanego, Dilys Addy, Trisevgeni Crabb, Carryl Dryden, Sarah Inglott, Dariusz Ladon, Gary Wright, Jack Bartram, Philip Ancliff, Adam J Mead, Christina Halsey, Irene Roberts, Thomas A

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia

幼年型骨髓单核细胞白血病中异质性疾病传播干细胞

Eleni Louka # ,Benjamin Povinelli # ,Alba Rodriguez-Meira ,Gemma Buck ,Wei Xiong Wen ,Guanlin Wang ,Nikolaos Sousos ,Neil Ashley ,Angela Hamblin ,Christopher A G Booth ,Anindita Roy ,Natalina Elliott ,Deena Iskander ,Josu de la Fuente ,Nicholas Fordham ,Sorcha O'Byrne ,Sarah Inglott ,Ruggiero Norfo ,Mariolina Salio ,Supat Thongjuea ,Anupama Rao ,Irene Roberts # ,Adam J Mead #

Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human development

人类发育过程中造血干/祖细胞谱系分化和基因调控网络的转变

Anindita Roy ,Guanlin Wang ,Deena Iskander ,Sorcha O'Byrne ,Natalina Elliott ,Jennifer O'Sullivan ,Gemma Buck ,Elisabeth F Heuston ,Wei Xiong Wen ,Alba Rodriguez Meira ,Peng Hua ,Anastasios Karadimitris ,Adam J Mead ,David M Bodine ,Irene Roberts ,Bethan Psaila ,Supat Thongjuea

A KMT2A-AFF1 gene regulatory network highlights the role of core transcription factors and reveals the regulatory logic of key downstream target genes

KMT2A-AFF1 基因调控网络突出了核心转录因子的作用并揭示了关键下游靶基因的调控逻辑

Joe R Harman #, Ross Thorne #, Max Jamilly, Marta Tapia, Nicholas T Crump, Siobhan Rice, Ryan Beveridge, Edward Morrissey, Marella F T R de Bruijn, Irene Roberts, Anindita Roy, Tudor A Fulga, Thomas A Milne

Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets

单细胞分析揭示骨髓纤维化中巨核细胞偏向性造血,并鉴定突变克隆特异性靶点

Bethan Psaila ,Guanlin Wang ,Alba Rodriguez-Meira ,Rong Li ,Elisabeth F Heuston ,Lauren Murphy ,Daniel Yee ,Ian S Hitchcock ,Nikolaos Sousos ,Jennifer O'Sullivan ,Stacie Anderson ,Yotis A Senis ,Olga K Weinberg ,Monica L Calicchio ,Daniel Royston ,Dragana Milojkovic ,Irene Roberts ,David M Bodine ,Supat Thongjuea ,Adam J Mead

Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome

唐氏综合征患儿髓系前白血病进展为转化型髓系白血病的机制

Maurice Labuhn ,Kelly Perkins ,Sören Matzk ,Leila Varghese ,Catherine Garnett ,Elli Papaemmanuil ,Marlen Metzner ,Alison Kennedy ,Vyacheslav Amstislavskiy ,Thomas Risch ,Raj Bhayadia ,David Samulowski ,David Cruz Hernandez ,Bilyana Stoilova ,Valentina Iotchkova ,Udo Oppermann ,Carina Scheer ,Kenichi Yoshida ,Adrian Schwarzer ,Jeffrey W Taub ,John D Crispino ,Mitchell J Weiss ,Yasuhide Hayashi ,Takashi Taga ,Etsuro Ito ,Seishi Ogawa ,Dirk Reinhardt ,Marie-Laure Yaspo ,Peter J Campbell ,Irene Roberts ,Stefan N Constantinescu ,Paresh Vyas ,Dirk Heckl ,Jan-Henning Klusmann