日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Model-Informed Deep Q-Networks to Guide Infliximab Dosing in Pediatric Crohn's Disease

基于模型的深度Q网络指导儿童克罗恩病英夫利昔单抗给药

期刊:Clinical Pharmacology & Therapeutics
影响因子:5.5
doi:10.1002/cpt.70118
Irie, Kei; Minar, Phillip; Reifenberg, Jack; Boyle, Brendan M; Noe, Joshua D; Hyams, Jeffrey S; Mizuno, Tomoyuki
克罗恩病
发表日期：2026
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Machine Learning Modeling for Predicting Infliximab Pharmacokinetics in Pediatric and Young Adult Patients With Crohn Disease: Leveraging Ensemble Modeling With Synthetic and Real-World Data

利用机器学习模型预测英夫利昔单抗在克罗恩病患儿及青少年患者中的药代动力学：结合合成数据和真实世界数据的集成建模

期刊:Therapeutic Drug Monitoring
影响因子:2.4
doi:10.1097/FTD.0000000000001348
Irie, Kei; Minar, Phillip; Reifenberg, Jack; Boyle, Brendan M; Noe, Joshua D; Hyams, Jeffrey S; Mizuno, Tomoyuki
克罗恩病
发表日期：2026
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Give weekly adalimumab a chance before discontinuing it: a retrospective clinical and pharmacokinetic analysis in pediatric rheumatology

在停用阿达木单抗之前，不妨先尝试每周一次的治疗：儿科风湿病学回顾性临床和药代动力学分析

期刊:Arthritis Research & Therapy
影响因子:4.6
doi:10.1186/s13075-025-03688-4
Burlo, Francesca; Pastore, Serena; Stocco, Gabriele; Zuanna, Paolo Dalla; Curci, Debora; Mizuno, Tomoyuki; Irie, Kei; Taddio, Andrea; Tommasini, Alberto
发表日期：2025
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Physiologically Based Pharmacokinetic Modeling of Antibiotics in Children: Perspectives on Model-Informed Precision Dosing

儿童抗生素生理药代动力学模型：模型指导下的精准给药展望

期刊:Antibiotics-Basel
影响因子:4.6
doi:10.3390/antibiotics14060541
Tanaka, Ryota; Irie, Kei; Mizuno, Tomoyuki
发表日期：2025
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Model-informed dose optimization for prophylactic piperacillin-tazobactam in perioperative pediatric critically ill patients

基于模型的围手术期儿科危重患者预防性哌拉西林-他唑巴坦剂量优化

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/aac.01227-24
Tan, Wen Rui; Irie, Kei; McIntire, Carter; Torres, Julie Luna; Jones, Rhonda; Gibson, Abigayle; Mizuno, Tomoyuki; Tang Girdwood, Sonya
发表日期：2025
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Hybrid Population Pharmacokinetic-Machine Learning Modeling to Predict Infliximab Pharmacokinetics in Pediatric and Young Adult Patients with Crohn's Disease

采用混合群体药代动力学-机器学习模型预测克罗恩病患儿及青少年患者的英夫利昔单抗药代动力学

期刊:Clinical Pharmacokinetics
影响因子:4
doi:10.1007/s40262-025-01564-7
Irie, Kei; Minar, Phillip; Reifenberg, Jack; Boyle, Brendan M; Noe, Joshua D; Hyams, Jeffrey S; Mizuno, Tomoyuki
克罗恩病
发表日期：2025
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Integrating early response biomarkers in pharmacokinetic models: A novel method to individualize the initial infliximab dose in patients with Crohn's disease

将早期反应生物标志物整合到药代动力学模型中：一种为克罗恩病患者个体化设定英夫利昔单抗初始剂量的新方法

期刊:Cts-Clinical and Translational Science
影响因子:2.8
doi:10.1111/cts.70086
Samuels, Abigail; Irie, Kei; Mizuno, Tomoyuki; Reifenberg, Jack; Punt, Nieko; Vinks, Alexander A; Minar, Phillip
克罗恩病
发表日期：2025
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Volumetric Absorptive Microsampling Combined with Mass Spectrometry to Support Pharmacokinetically-Guided Precision Dosing of Mycophenolate Mofetil in Pediatric Lupus Nephritis Patients

体积吸收微量取样结合质谱法支持儿科狼疮性肾炎患者吗替麦考酚酯的药代动力学指导精准给药

期刊:Journal of Applied Laboratory Medicine
影响因子:1.9
doi:10.1093/jalm/jfaf022
Zhao, Junfang; Zhao, Xueheng; Mizuno, Tomoyuki; Irie, Kei; Devarajan, Prasad; Brunner, Hermine I; Setchell, Kenneth D R
肾炎
发表日期：2025
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Effect of Hematopoietic Stem Cell Transplantation Regimen on Tacrolimus Pharmacokinetics.

造血干细胞移植方案对他克莫司药代动力学的影响

期刊:Current Therapeutic Research-Clinical and Experimental
影响因子:1.5
doi:10.1016/j.curtheres.2024.100775
Oku Haruno, Yoshida Saki, Hotta Takumi, Muroi Hirohito, Fukushima Keizo, Irie Kei, Hirano Tatsuya, Shimomura Yoshimitsu, Ishikawa Takayuki, Ikesue Hiroaki, Muroi Nobuyuki, Hashida Tohru, Sugioka Nobuyuki
发育与干细胞
细胞生物学
发表日期：2025
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Hybrid Population PK-Machine Learning Modeling to Predict Infliximab Pharmacokinetics in Pediatric and Young Adult Patients with Crohn's Disease

采用混合群体药代动力学-机器学习模型预测克罗恩病患儿及青少年患者的英夫利昔单抗药代动力学

期刊:
影响因子:
doi:10.1101/2025.05.01.651780
Irie, Kei; Minar, Phillip; Reifenberg, Jack; Boyle, Brendan M; Noe, Joshua D; Hyams, Jeffrey S; Mizuno, Tomoyuki
克罗恩病
发表日期：2025
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