日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Large-scale RNA-Seq mining reveals ciclopirox olamine induces TDP-43 cryptic exons.

大规模 RNA-Seq 挖掘揭示环吡咯醇胺诱导 TDP-43 隐蔽外显子

Sinha Irika R, Sandal Parker S, Spence Holly, Burns Grace D, Mallika Aswathy Peethambaran, Abbasinejad Fatemeh, Irwin Katherine E, Cruz Anna Lourdes F, Wang Vania, Marx Shaelyn R, Rodríguez Josué Llamas, Langmead Ben, Gregory Jenna M, Wong Philip C, Ling Jonathan P

Distinct and convergent effects of SF3B1 mutations in human breast cancer

SF3B1突变在人类乳腺癌中的独特和趋同效应

Bergman, Riley E; Keeton, Christin I; Sinha, Irika R; Ling, Jonathan P; Wang, Yu; Ha, Lauren; Mehta, Eshani P; Reed, Sarah C; Fox, Ethan K; O'Grady, Tina M; Yu, Yingying; Fragkogianni, Stamatina; Chao, Calvin; Davidson, Brad A; Miranda, Adam X; Croessmann, Sarah; Zhao, Shilin; Liu, Qi; Shyr, Yu; Dalton, W Brian; Hurley, Paula J; Park, Ben H

5-ethynyluridine perturbs nuclear RNA metabolism to promote the nuclear accumulation of TDP-43 and other RNA binding proteins

5-乙炔基尿苷扰乱核内RNA代谢,促进TDP-43和其他RNA结合蛋白在核内积累。

Hayes, Lindsey R; Zaepfel, Benjamin; Duan, Lauren; Starner, Anne C; Bartels, Mason D; Rothacher, Rebekah L; Martin, Sophie; French, Rachel; Zhang, Zhe; Sinha, Irika R; Ling, Jonathan P; Sun, Shuying; Ayala, Yuna M; Coller, Jeff; Van Nostrand, Eric L; Florea, Liliana; Kalab, Petr

Broad brain biodistribution conferred by an AAV to restore TDP-43 function mitigates Frontotemporal Demenia-like deficits

通过腺相关病毒(AAV)实现广泛的脑生物分布,从而恢复TDP-43功能,减轻额颞叶痴呆样症状。

Cao, Tianyu; Thapa, Rashmi; Liu, Rongsong; Mallika, Aswathy Peethambaran; Baghel, Meghraj Singh; Wei, Yijun; Sinha, Irika R; Burns, Grace D; Wen, Xinrui; Pang, Bo; Ling, Jonathan P; Lin, Da-Ting; Li, Yun; Wong, Philip C

Symptomatic treatment by a BBB-permeable AAV engineered to restore TDP-43 function slows motor neuron disease and prevents paralysis

利用经基因工程改造、可穿透血脑屏障的腺相关病毒(AAV)进行对症治疗,能够恢复TDP-43功能,从而延缓运动神经元疾病的进展并预防瘫痪。

Peethambaran Mallika, Aswathy; Yu, Jessica G; Sitzman, Opal; Baghel, Meghraj Singh; Renganathan, Shruti; Sinha, Irika R; Melnikova, Tatiana; Ling, Jonathan P; Wong, Philip C

Inhibition of nonsense-mediated decay in TDP-43 deficient neurons reveals novel cryptic exons

抑制TDP-43缺陷神经元中的无义介导衰变可揭示新的隐蔽外显子

Sinha, Irika R; Ye, Yingzhi; Li, Yini; Sandal, Parker S; Wong, Philip C; Sun, Shuying; Ling, Jonathan P

Brain Iron as a Surrogate Biomarker of Pathological TDP-43 Identifies Brain Region-Specific Signatures in Ageing, Alzheimer's Disease and Amyotrophic Lateral Sclerosis.

脑铁作为病理性 TDP-43 的替代生物标志物,可识别衰老、阿尔茨海默病和肌萎缩侧索硬化症中脑区特异性特征。

Waldron Fergal M, Spence Holly, Taso Orjona Stella, Read Fiona L, Sinha Irika R, Irwin Katherine E, Wong Philip C, Ling Jonathan P, Gregory Jenna M

A fluid biomarker reveals loss of TDP-43 splicing repression in presymptomatic ALS-FTD

液体生物标志物揭示了 ALS-FTD 症状前 TDP-43 剪接抑制的丧失

Katherine E Irwin, Pei Jasin, Kerstin E Braunstein, Irika R Sinha, Mark A Garret, Kyra D Bowden, Koping Chang, Juan C Troncoso, Abhay Moghekar, Esther S Oh, Denitza Raitcheva, Dan Bartlett, Timothy Miller, James D Berry, Bryan J Traynor, Jonathan P Ling, Philip C Wong

Author Correction: A fluid biomarker reveals loss of TDP-43 splicing repression in presymptomatic ALS-FTD

作者更正:一项体液生物标志物揭示了ALS-FTD前驱期患者TDP-43剪接抑制的丧失。

Irwin, Katherine E; Jasin, Pei; Braunstein, Kerstin E; Sinha, Irika R; Garret, Mark A; Bowden, Kyra D; Chang, Koping; Troncoso, Juan C; Moghekar, Abhay; Oh, Esther S; Raitcheva, Denitza; Bartlett, Dan; Miller, Timothy; Berry, James D; Traynor, Bryan J; Ling, Jonathan P; Wong, Philip C

Targeting RSV-neutralizing B cell receptors with anti-idiotypic antibodies

利用抗独特型抗体靶向RSV中和B细胞受体

Samuel C Scharffenberger ,Yu-Hsin Wan ,Leah J Homad ,Gargi Kher ,Austin M Haynes ,Bibhav Poudel ,Irika R Sinha ,Nicholas Aldridge ,Ayana Pai ,Madeleine Bibby ,Crystal B Chhan ,Amelia R Davis ,Zoe Moodie ,Maria Belen Palacio ,Amelia Escolano ,M Juliana McElrath ,Jim Boonyaratanakornkit ,Marie Pancera ,Andrew T McGuire