日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Leptospirosis-associated pulmonary hemorrhagic syndrome: immune mechanisms, clinical manifestations, and experimental models

钩端螺旋体病相关肺出血综合征：免疫机制、临床表现和实验模型

期刊:Revista Do Instituto De Medicina Tropical De Sao Paulo
影响因子:1.7
doi:10.1590/S1678-9946202668009
Silva, Lara Rodrigues da; Carneiro, Milena Carvalho; Lorga, Ana Carolina Mikejevs; Santos, Luana Barbosa Rodrigues Dos; Midon, Leonardo Moura; Duarte Neto, Amaro Nunes; Amamura, Thais Akemi; Isaac, Lourdes
免疫/内分泌
发表日期：2026
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Complement C3 deficiency enhances renal leptospiral load and inflammation while impairing T cell differentiation during chronic Leptospira interrogans infection

补体C3缺乏会加剧肾脏钩端螺旋体负荷和炎症，同时损害慢性钩端螺旋体感染期间的T细胞分化。

期刊:Infection and Immunity
影响因子:2.8
doi:10.1128/iai.00398-25
Moura Midon, Leonardo; Duarte Neto, Amaro Nunes; Maria Gonçalves da Silva, Ana; Bryan Heinemann, Marcos; Kundu, Suman; Gomes-Solecki, Maria; Isaac, Lourdes
炎症
T细胞
炎症/感染
T细胞
细胞生物学
免疫/内分泌
发表日期：2025
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Editorial: Leptospirosis: pathogenesis, clinical and epidemiological aspects

社论：钩端螺旋体病：发病机制、临床和流行病学方面

期刊:Frontiers in Cellular and Infection Microbiology
影响因子:4.8
doi:10.3389/fcimb.2023.1210178
Barbosa, Angela S; Patarakul, Kanitha; Isaac, Lourdes
发表日期：2023
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Sph2((176-191)) and Sph2((446-459)): Identification of B-Cell Linear Epitopes in Sphingomyelinase 2 (Sph2), Naturally Recognized by Patients Infected by Pathogenic Leptospires

Sph2((176-191))和Sph2((446-459))：鞘磷脂酶2 (Sph2)中B细胞线性表位的鉴定，可由感染致病性钩端螺旋体的患者自然识别

期刊:Vaccines
影响因子:3.4
doi:10.3390/vaccines11020359
Ataides, Laura Sant'Anna; de Moraes Maia, Fernanda; Conte, Fernando Paiva; Isaac, Lourdes; Barbosa, Angela Silva; da Costa Lima-Junior, Josué; Avelar, Kátia Eliane Santos; Rodrigues-da-Silva, Rodrigo Nunes
炎症/感染
细胞生物学
B细胞
免疫/内分泌
发表日期：2023
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A rare association between factor H deficiency and lupus: Case report and experimental treatment with curcumin

因子H缺乏症与狼疮罕见关联：病例报告及姜黄素实验治疗

期刊:Frontiers in Pediatrics
影响因子:2
doi:10.3389/fped.2022.1039291
Lunz Macedo, Ana Catarina; Santisteban Lores, Lazara Elena; Albuquerque, José Antonio Tavares; Duarte, Nilo José Coelho; Romano, Paschoalina; Ebner, Persio Almeida Rezende; Rezende, Vinicius Marcondes; Silva, Clovis A; Andrade, Luís Eduardo Coelho; Vasconcelos, Dewton Moraes; Isaac, Lourdes
发表日期：2022
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The Role of Properdin in Killing of Non-Pathogenic Leptospira biflexa

普罗珀丁在杀灭非致病性双歧钩端螺旋体中的作用

期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2020.572562
Martinez, Adriana Patricia Granados; Abreu, Patrícia Antonia Estima; de Arruda Vasconcellos, Silvio; Ho, Paulo Lee; Ferreira, Viviana P; Saggu, Gurpanna; Barbosa, Angela Silva; Isaac, Lourdes
发表日期：2020
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Cytokine Profile in Early Infection by Leptospira interrogans in A/J Mice

A/J小鼠早期感染钩端螺旋体时的细胞因子谱

期刊:Journal of Immunology Research
影响因子:3.6
doi:10.1155/2019/1892508
Bavia, Lorena; de Castro, Íris A; Amano, Mariane Tami; da Silva, Ana Maria Gonçalves; Vasconcellos, Silvio Arruda; Isaac, Lourdes
炎症/感染
细胞生物学
免疫/内分泌
发表日期：2019
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Role of Murine Complement Component C5 in Acute in Vivo Infection by Pathogenic Leptospira interrogans

小鼠补体成分C5在致病性钩端螺旋体急性体内感染中的作用

期刊:Frontiers in Cellular and Infection Microbiology
影响因子:4.8
doi:10.3389/fcimb.2018.00063
de Castro, Íris A; Bavia, Lorena; Fraga, Tatiana R; Amano, Mariane T; Breda, Leandro C D; Granados-Martinez, Adriana P; da Silva, Ana M G; Vasconcellos, Silvio A; Isaac, Lourdes
炎症/感染
免疫/内分泌
发表日期：2018
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Leptospira interrogans Secreted Proteases Degrade Extracellular Matrix and Plasma Proteins From the Host

钩端螺旋体分泌的蛋白酶降解宿主细胞外基质和血浆蛋白。

期刊:Frontiers in Cellular and Infection Microbiology
影响因子:4.8
doi:10.3389/fcimb.2018.00092
da Silva, Ludmila B; Menezes, Milene C; Kitano, Eduardo S; Oliveira, Ana K; Abreu, Afonso G; Souza, Gisele O; Heinemann, Marcos B; Isaac, Lourdes; Fraga, Tatiana R; Serrano, Solange M T; Barbosa, Angela S
细胞生物学
发表日期：2018
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Leptospira interrogans thermolysin refolded at high pressure and alkaline pH displays proteolytic activity against complement C3

钩端螺旋体嗜热菌溶素在高压和碱性pH条件下重折叠后，对补体C3表现出蛋白水解活性。

期刊:Biotechnology Reports
影响因子:
doi:10.1016/j.btre.2018.e00266
Chura-Chambi, Rosa Maria; Fraga, Tatiana Rodrigues; da Silva, Ludmila Bezerra; Yamamoto, Bruno Bernardi; Isaac, Lourdes; Barbosa, Angela Silva; Morganti, Ligia
免疫/内分泌
发表日期：2018
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