Partial rescue of F508del-cystic fibrosis transmembrane conductance regulator channel gating with modest improvement of protein processing, but not stability, by a dual-acting small molecule

通过双作用小分子部分挽救 F508del-囊性纤维化跨膜传导调节通道门控，适度改善蛋白质加工，但不改善稳定性