日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bispecific antibody CD73xEGFR more selectively inhibits the CD73/adenosine immune checkpoint on cancer cells and concurrently counteracts pro-oncogenic activities of CD73 and EGFR

双特异性抗体 CD73xEGFR 更有选择性地抑制癌细胞上的 CD73/腺苷免疫检查点,同时抵消 CD73 和 EGFR 的促癌活性

Emily Maria Ploeg, Douwe Freerk Samplonius, Xiao Xiong, Xiurong Ke, Mark Alexander Johannes Martinus Hendriks, Isabel Britsch, Anne Paulien van Wijngaarden, Hao Zhang, Wijnand Helfrich

Novel Fab-peptide-HLA-I fusion proteins for redirecting pre-existing anti-CMV T cell immunity to selective eliminate carcinoma cells

新型 Fab-肽-HLA-I 融合蛋白,用于重定向预先存在的抗 CMV T 细胞免疫以选择性消除癌细胞

Isabel Britsch, Anne P van Wijngaarden, Xiurong Ke, Mark A J M Hendriks, Douwe F Samplonius, Emily M Ploeg, Wijnand Helfrich

A Novel Bispecific Antibody for EpCAM-Directed Inhibition of the CD73/Adenosine Immune Checkpoint in Ovarian Cancer

一种新型双特异性抗体,用于 EpCAM 定向抑制卵巢癌中的 CD73/腺苷免疫检查点

Emily Maria Ploeg, Isabel Britsch, Anne Paulien van Wijngaarden, Xiurong Ke, Mark Alexander Johannes Martinus Hendriks, Douwe Freerk Samplonius, Wijnand Helfrich

Cancer cells under immune attack acquire CD47-mediated adaptive immune resistance independent of the myeloid CD47-SIRPα axis

受到免疫攻击的癌细胞获得独立于髓系 CD47-SIRPα 轴的 CD47 介导的适应性免疫抵抗力

Mark A J M Hendriks, Isabel Britsch, Xiurong Ke, Anne P van Wijngarden, Douwe F Samplonius, Emily M Ploeg, Wijnand Helfrich

Bispecific antibody approach for EGFR-directed blockade of the CD47-SIRPα "don't eat me" immune checkpoint promotes neutrophil-mediated trogoptosis and enhances antigen cross-presentation

双特异性抗体方法针对 EGFR 定向阻断 CD47-SIRPα“不要吃我”免疫检查点,促进中性粒细胞介导的嗜中性粒细胞凋亡并增强抗原交叉呈递

Mark A J M Hendriks, Emily M Ploeg, Iris Koopmans, Isabel Britsch, Xiurong Ke, Douwe F Samplonius, Wijnand Helfrich