文献库，生知库 | 链接生命科学的每一步

日期影响因子

Beneficial Effect of Dimethyl Fumarate Drug Repositioning in a Mouse Model of TDP-43-Dependent Frontotemporal Dementia

富马酸二甲酯药物重新定位对 TDP-43 依赖性额颞叶痴呆小鼠模型的有益作用

期刊:Antioxidants

doi:10.3390/antiox13091072

Ignacio Silva-Llanes, Raquel Martín-Baquero, Alicia Berrojo-Armisen, Carmen Rodríguez-Cueto, Javier Fernández-Ruiz, Eva De Lago, Isabel Lastres-Becker

发表日期：2024

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The Transcription Factor NRF2 Has Epigenetic Regulatory Functions Modulating HDACs, DNMTs, and miRNA Biogenesis

转录因子 NRF2 具有调节 HDAC、DNMT 和 miRNA 生物合成的表观遗传调控功能

期刊:Antioxidants

doi:10.3390/antiox12030641

Ignacio Silva-Llanes, Chang Hoon Shin, José Jiménez-Villegas, Myriam Gorospe, Isabel Lastres-Becker

发表日期：2023

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Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis

多靶点混合法舒地尔衍生物作为治疗肌萎缩侧索硬化症的新方法

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.1c01255

Olmo Martín-Cámara, Marina Arribas, Geoffrey Wells, Marcos Morales-Tenorio, Ángeles Martín-Requero, Gracia Porras, Ana Martínez, Giorgio Giorgi, Pilar López-Alvarado, Isabel Lastres-Becker, J Carlos Menéndez

多发性硬化症

发表日期：2022

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α-Synuclein Induces the GSK-3-Mediated Phosphorylation and Degradation of NURR1 and Loss of Dopaminergic Hallmarks

α-突触核蛋白诱导 GSK-3 介导的 NURR1 磷酸化和降解以及多巴胺能标志的丧失

期刊:Molecular Neurobiology

影响因子:4.6

doi:10.1007/s12035-021-02558-9

Ángel Juan García-Yagüe, Isabel Lastres-Becker, Leonidas Stefanis, Demetrios K Vassilatis, Antonio Cuadrado1

发表日期：2021

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Molecular Alterations in Sporadic and SOD1-ALS Immortalized Lymphocytes: Towards a Personalized Therapy

散发性和 SOD1-ALS 永生化淋巴细胞的分子改变：迈向个性化治疗

期刊:International Journal of Molecular Sciences

影响因子:0.7

doi:10.3390/ijms22063007

Isabel Lastres-Becker, Gracia Porras, Marina Arribas-Blázquez, Inés Maestro, Daniel Borrego-Hernández, Patricia Boya, Sebastián Cerdán, Alberto García-Redondo, Ana Martínez, Ángeles Martin-Requero

细胞生物学

发表日期：2021

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NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling

NRF2依赖性基因表达促进纤毛发生和Hedgehog信号传导

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-019-50356-0

Ana Martin-Hurtado, Raquel Martin-Morales, Natalia Robledinos-Antón, Ruth Blanco, Ines Palacios-Blanco, Isabel Lastres-Becker, Antonio Cuadrado, Francesc R Garcia-Gonzalo

发表日期：2019

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Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy

GSK-3 和 NRF2 的药理靶向作用在 tau 蛋白病的临床前模型中提供了神经保护作用

期刊:Redox Biology

影响因子:10.7

doi:10.1016/j.redox.2017.10.010

Antonio Cuadrado, Sebastian Kügler, Isabel Lastres-Becker

发表日期：2018

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Cx3cr1-deficiency exacerbates alpha-synuclein-A53T induced neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease

Cx3cr1 缺乏会加剧帕金森病小鼠模型中 α-突触核蛋白-A53T 诱发的神经炎症和神经退行性

影响因子:5.4

doi:10.1002/glia.23338

Sara Castro-Sánchez, Ángel J García-Yagüe, Tresa López-Royo, Maria Casarejos, José Luis Lanciego, Isabel Lastres-Becker

发表日期：2018

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Mammalian ataxin-2 modulates translation control at the pre-initiation complex via PI3K/mTOR and is induced by starvation

哺乳动物共济失调蛋白-2通过PI3K/mTOR调节起始前复合物的翻译控制，并由饥饿诱导

影响因子:3.3

doi:10.1016/j.bbadis.2016.05.017

Isabel Lastres-Becker, David Nonis, Florian Eich, Michael Klinkenberg, Myriam Gorospe, Peter Kötter, Fabrice A C Klein, Nancy Kedersha, Georg Auburger

Translational Control

发表日期：2016

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Transcription factors NRF2 and NF-κB are coordinated effectors of the Rho family, GTP-binding protein RAC1 during inflammation

转录因子 NRF2 和 NF-κB 是炎症过程中 Rho 家族、GTP 结合蛋白 RAC1 的协调效应物

期刊:Journal of Biological Chemistry

doi:10.1074/jbc.M113.540633

Antonio Cuadrado, Zaira Martín-Moldes, Jianping Ye, Isabel Lastres-Becker

发表日期：2014

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